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ATPase

ATPases ( adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, adenosine 5'-triphosphatase, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion[1][2][3][4][5][6] or the inverse reaction. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur.

  • Tirofiban hydrochloride monohydrate
    T2537150915-40-5
    Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
    • $40
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  • Blebbistatin
    T21550674289-55-5
    Blebbistatin ((±)-Blebbistatin) is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing. Furthermore it preserves cell junctional integrity and barrier function.Blebbistatin is an inhibitor of MYH9.
    • $30
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  • Matairesinol
    TN1916580-72-3
    Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.
    • $82
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  • Esomeprazole Sodium
    T2686L161796-78-7
    Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
    • $41
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  • Sodium oleate
    T36390143-19-1
    Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator.
    • $42
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  • Revaprazan hydrochloride
    T2405178307-42-1
    Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.
    • $37
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  • trans-Aconitic acid
    T48614023-65-8
    Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase (EC 2.1.
    • $56
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  • (S)-PF-03716556
    T2093L928774-44-1In house
    (S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.
    • $195 TargetMol
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  • AGN-201904
    T23667651729-53-2In house
    AGN-201904 is a proton pump inhibitor, an omeprazole prodrug, which delays aging and may be used for the prevention and treatment of peptic ulcers.
    • $293
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  • Leminoprazole
    T27812104340-86-5In house
    Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages.
    • $130 TargetMol
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  • NC-1300-B
    T28136104340-52-5In house
    NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers.
    • $293 TargetMol
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  • Sudoterb free base
    T3480676266-31-2In house
    Sudoterb free base (Sudoterb) , also known as LL3858, is an anti-tubercular drug candidate.
    • $68
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  • FR-167356
    T27371174185-16-1In house
    FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.
    • $197
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  • Transdermal Peptide Disulfide Acetate
    TP1033L
    Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.Transdermal Peptide TD 1 Amide is novel peptide designed to enhance transdermal drug delivery.
    • $78
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  • Tiludronate disodium
    T13159149845-07-8In house
    Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
    • $73
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  • PF 03716556
    T2093928774-43-0In house
    PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.
    • $35 TargetMol
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  • Lanatoside C
    T167017575-22-3
    Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intravenous route.
    • $67
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  • Oleandrin
    T5S0890465-16-7
    1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
    • $98
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  • FCCP
    T6834370-86-5
    FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.
    • $36
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  • (-)-Blebbistatin
    T6038856925-71-8
    (-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.
    • $35
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  • Eniporide
    T2089176644-21-6
    Eniporide is a Na(+)/H(+) exchange inhibitor.
    • $46
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  • ATPase-IN-3
    T839671134203-12-5
    ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.
    • $35
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  • Cycloartane-3,24,25-triol
    TN373757576-29-1
    Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
    • $620
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  • (-)-Denudatin B
    TN383187402-88-8
    (-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.
    • $85
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  • Echinatine
    TN3914480-83-1
    Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil
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  • Mitiglinide Calcium
    T6587145525-41-3
    Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
    • $48
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  • Dihydroisotanshinone I
    TN158820958-18-3
    Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation.
    • $1,980
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  • Marinobufogenin
    TN1912470-42-8
    Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
    • $143
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  • BRITE-338733
    T22280503105-88-2
    BRITE-338733 is a novel inhibitor of ATPase. BRITE 338733 inhibits the expression of RecA in bacteria with IC50 value of 4.7 μM for the bacterial infections treatment.
    • $64
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  • Zeorin
    TN527922570-53-2
    Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release.
    • $1,698
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  • Rbin-1
    T7411328023-11-6
    Rbin-1 (Ribozinoindole-1) is a potent,specific inhibitor of eukaryotic ribosome biogenesis.
    • $64
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  • Stauntosaponin A
    TN50601417887-91-2
    Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
    • $2,039
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  • DHQ
    T2043615804-19-0
    DHQ (2,3-dihydroxy-quinoxalin) is an inducer of ATPase activity that of Herpes Simplex Virus thymidine kinase.
    • $39
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  • Prilocaine
    T6953721-50-6
    Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
    • $33
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  • Strictosamide
    TN223923141-25-5
    Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
    • $57
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  • Deslanoside
    T818317598-65-1
    Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations.
    • $80
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  • Clorsulon
    T113760200-06-8
    Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep.
    • $42
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  • Encecalin
    TN393020628-09-5
    Encecalin and demethylencecalin are major phytotoxic compounds isolated from Helianthella quinquenervis (Hook) A Gray (Asteraceae), they inhibit photosystem II (from water to 2,5-dibromo-3-methyl-6-isopropyl-1,4 p-benzo-quinone).They retard seed germinati
    • $400
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  • (-)-Praeruptorin A
    TN481914017-71-1
    (-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
    • $320
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  • Rostafuroxin
    T2621156722-18-8
    Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.
    • $37
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    TargetMol | Citations Cited
  • Esomeprazole Magnesium
    T2686161973-10-0
    Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases
    • $35
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  • Strophanthidin
    TN507366-28-4
    Strophanthidin (Strophanthidine) can induce calcium overload in vivo.
    • $39
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  • (+)-SJ733
    T173131424799-20-1
    (+)-SJ733 (SJ000557733) is a potent Na+-ATPase PfATP4 inhibitor with antimalarial activity for the study of malaria.
    • $249
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  • SCH28080
    T1686576081-98-6
    SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, anti-secretory and cytoprotective activity.
    • $47
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  • KM 91104
    T9230304481-60-5
    KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2.
    • $80
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  • Mtb ATP synthase-IN-1
    T608772642394-38-3
    Mtb ATP synthase-IN-1 is an orally available inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthesis for the study of Mycobacterium tuberculosis infections.
    • $38
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  • Omecamtiv mecarbil
    T2006873697-71-3
    Omecamtiv mecarbil (CK-1827452) has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.
    • $34
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  • Brefeldin A
    T606220350-15-6
    Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.
    • $34
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  • ATP synthase inhibitor 1
    T104041023043-30-2
    ATP synthase inhibitor 1 is an inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening and does not affect ATP levels.
    • $54
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  • Vonoprazan fumarate
    T24041260141-27-2
    Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.
    • $39
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