ac 3

Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I). It acts as a highly specific inhibitor of Calmodulin-Dependent Protein Kinase II (CaMKII) with enhanced resistance to proteolysis. This compound is a derivative of Autocamtide-3, where the Thr-9 phosphorylation site is replaced by Ala.

Fmoc-Thr(GalNAc(Ac)3-β-D)-OH impedes cancer cell proliferation by selectively interacting with complex oncogenic pathways and enhancing the immune response [1].

Fmoc-THR(GalNAc(Ac)3-α-D)-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-THR(GalNAc(Ac)3-α-D)-OH is a starting material to make trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates.

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide that binds to the src SH2 domain with an IC50 value of approximately 1 µM and inhibits src SH3-SH2: phosphoprotein interactions [1].

Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.

HDAC-IN-30 is a multi-target HDAC inhibitor. HDAC-IN-30 inhibits HDAC1 (IC50 =13.4 nM), HDAC2 (IC50 =28.0 nM), HDAC3 (IC50 =9.18 nM), HDAC6 (IC50 =42.7 nM), HDAC8 (IC50 =131 nM). HDAC-IN-30 shows potent antitumor efficacy.

Fmoc-Ser(O-β-D-GalNAc(OAc)3)-OH (catalog number: T66662, CAS number: 160067-63-0) is a valuable organic compound for life sciences research.

EAC3I, an autocamtide-3 derived inhibitory peptide with the sequence KKALHRQEAVDAL, is a bioactive peptide that mimics the autoinhibitory region of the CaMKII regulatory domain (residues 278–290). It functions by competitively binding to the enzyme's catalytic site.

Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .

Ac-VDVAD-AFC, a caspase-specific fluorescent substrate, detects caspase-3-like and caspase-2 activities, making it valuable for tumor and cancer-related research.

Ac-D-Ala-OH is a useful organic compound for research related to life sciences. The catalog number is T64967 and the CAS number is 19436-52-3.

AC-VEID-CHO (TFA) is a peptide-derived inhibitor targeting Caspases-6, -3, and -7, with IC50 values of 16.2 nM, 13.6 nM, and 162.1 nM, respectively. This compound demonstrates significant inhibitory potency and is applicable in the study of neurodegenerative diseases, such as Alzheimer's and Huntington's disease [1].

Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective, irreversible caspase-3 inhibitor, preventing apoptosis induced by elevated glucose levels or 3,20-dibenzoate (IDB) in various experimental contexts, as supported by references [1] [2] [3].

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for the 26S proteasome, utilized for analyzing the proteasome's caspase-like activity [1] [2] [3].

Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.

Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site [1] [2].

Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible inhibitor of caspase-3 [1].

Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, with IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7 nM, respectively. This compound is utilized in the study of diseases associated with caspase-mediated apoptosis, including neurodegenerative and viral infection diseases [1].

AC-DEVD-AFC, a fluorogenic substrate, undergoes cleavage by caspase-3, producing a blue fluorescent compound upon excitation at 400 nm, which can be quantified at an emission maximum of 505 nm.

Acetyl decapeptide-3 is a peptide that can stimulate collagen and elastin to increase skin elasticity and increase cell growth and improve healing and repair.

Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.

Ac-DMQD-AMC TFA is a fluorescent substrate for Caspase-3 or Caspase-10, analogous to Ac-DEVD-AMC, capable of releasing the fluorescent group AMC (7-amino-4-methylcoumarin), thereby emitting fluorescence. Ac-DMQD-AMC TFA is useful for measuring Caspase activity in vitro during apoptosis monitoring.

Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM) with inhibitory effects on SLNT-induced apoptosis.