Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • PROTACs
    (16)
  • Apoptosis
    (9)
  • E1/E2/E3 Enzyme
    (7)
  • Autophagy
    (5)
  • DUB
    (5)
  • HDAC
    (4)
  • p53
    (3)
  • Mdm2
    (2)
  • NF-κB
    (2)
  • Others
    (65)
Filter
Search Result
Results for "

Ubiquitination

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    102
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    3
    TargetMol | Compound_Libraries
  • Peptide Products
    5
    TargetMol | Peptide_Products
  • PROTAC Products
    40
    TargetMol | PROTAC
  • Natural Products
    2
    TargetMol | Natural_Products
  • Recombinant Protein
    65
    TargetMol | Recombinant_Protein
PR-619
PR 619, 2,6-Diamino-3,5-dithiocyanopyridine
T18622645-32-1
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor that inhibits USP2 4 5 7 8 (EC50=7.2 3.93 8.61 6.86 4.9 μM). PR-619 induces endoplasmic reticulum stress and activates autophagy.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Ubiquitination-IN-1
T132441819330-15-8
Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
Ubiquitination-IN-2
T75030
Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein−protein interactions (PPI), exhibiting inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the transfer of ubiquitin from E1 to E2, Ubiquitination-IN-2 serves as a valuable tool in cancer research [1].
  • Inquiry Price
Size
QTY
c004019
T678342417159-57-8In house
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
  • Inquiry Price
8-10 weeks
Size
QTY
TargetMol | Inhibitor Hot
USP30 inhibitor 18
T366822242582-40-5In house
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.
  • Inquiry Price
6-8 weeks
Size
QTY
HM90822
HM-90822, HM 90822
T708681363145-46-3In house
HM90822 is a novel synthetic apoptotic protein (IAP) antagonist that induces apoptosis in human pancreatic cancer cells through proteasome-dependent degradation of IAPs containing the BIR2 3 structural domain.HM90822 inhibits the expression of XIAP and cIAP1 2 proteins in HM822-sensitive Panc-1 and BxPC-3 cells, induces ubiquitylation of IAPs and promotes induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.
  • Inquiry Price
8-10 weeks
Size
QTY
dCeMM3 
2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide
T9758311787-85-6In house
dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradation of cyclin K.
  • Inquiry Price
Size
QTY
Nrf2 degrader 30
Compound 30
T2013953025286-29-4
Nrf2 degrader 30 is a small molecule PROTAC that inhibits the degradation of Nrf2, thereby enhancing its activity. Nrf2 is a key transcription factor that regulates cellular antioxidant responses and various protective mechanisms. The activity of Nrf2 is primarily regulated by its interaction with Keap1, which serves as an E3 ubiquitin ligase complex adapter to promote Nrf2 ubiquitination and proteasomal degradation。
  • Inquiry Price
Size
QTY
USP7-IN-4
USP7-IN-2, USP7 inhibitor ALM4, AD-04
T698202196243-57-7
USP7-IN-4(USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4;11 (acute lymphoblastic leukemia cell line) .
  • Inquiry Price
6-8 weeks
Size
QTY
TAK-243
MLN7243
T169741450833-55-2
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.
  • Inquiry Price
Size
QTY
CYM5442
T20261094042-01-9
CYM5442 is an S1P agonist, targeting to Sphingosine.
  • Inquiry Price
Size
QTY
LANOSTEROL
8,24-Lanostadien-3β-ol, 3β-Hydroxy-8,24-lanostadiene
T497079-63-0
Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.
  • Inquiry Price
Size
QTY
Protosappanin B
Q-100961, FT-0689654
T6S1780102036-29-3
1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.
  • Inquiry Price
Size
QTY
ICCB-19 hydrochloride
ICCB-19 HCl(750621-52-4 free base)
T8931L1803605-68-6
ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
E3 ligase Ligand 8
T178791225383-33-4
E3 ligase Ligand 8, a ligand for E3 ubiquitin ligase, can be connected to protein ligands through linkers to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
GS143
GS-143, GS 143
T25465916232-21-8
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. It suppresses NF-κB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
MID-1
T8773312608-54-1
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Apcin-A
T103451683617-62-0
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.
  • Inquiry Price
1-2 weeks
Size
QTY
CP5V
T108752509359-75-3
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.
  • Inquiry Price
7-10 days
Size
QTY
PROTAC Mcl1 degrader-1
T119752163793-38-0
PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC), a selective Mcl-1 inhibitor. By hijacking the CRBN ubiquitin ligase to form a ternary complex with the target protein, it induces Mcl-1 ubiquitination. It can be used for cancer research.
  • Inquiry Price
Size
QTY
MF-094
T120242241025-68-1
MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
CC0651
T148961319207-44-7
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme that potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM).
  • Inquiry Price
8-10 weeks
Size
QTY
Smurf1-IN-A01
A01
T169041007647-73-5
Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (Kd: 3.664 nM) that enhances BMP-2 responsiveness by preventing Smurf1-mediated Smad1 5 degradation.
  • Inquiry Price
Size
QTY
TZ9
T171871002789-86-7
TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.
  • Inquiry Price
7-10 days
Size
QTY