Search Result

Search Results for " ubiquitination "

Targets

Compounds

Natural Products

128

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T13244	Ubiquitination-IN-1		Others
	Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).		Others
T75030	Ubiquitination-IN-2
	Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein−protein interactions (PPI), displaying inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the trans...
T21773	SP-141	SP 141	Mdm2
	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.		Mdm2
T8773	MID-1		Others , IGF-1R
	MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet...		Others , IGF-1R
T2026	CYM5442		S1P Receptor , LPL Receptor
	CYM5442 is an S1P agonist, targeting to Sphingosine.		S1P Receptor , LPL Receptor
T6697	TCID	UCH-L3 Inhibitor	DUB
	TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.		DUB
T1862	PR-619	PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis , DUB , Autophagy
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).		Apoptosis , DUB , Autophagy
T9758	DCeMM3	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide	Others
	dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati...		Others
T8931L	ICCB-19 hydrochloride	ICCB-19 HCl（750621-52-4 free base）	Apoptosis , Others , Autophagy , RIP kinase
	ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal dom...		Apoptosis , Others , Autophagy , RIP kinase
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T17187	TZ9		Apoptosis , E1/E2/E3 Enzyme
	TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.		Apoptosis , E1/E2/E3 Enzyme
T37042	SCH529074	SCH 529074	p53
	SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53.		p53
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T64339	Apcin A HCL		APC
	Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to...		APC
T36682	USP30 inhibitor 18		DUB
	USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o...		DUB
T61477	DCeMM2		Molecular Glues
	dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.		Molecular Glues
T73560	I-138		DUB
	I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.		DUB
T16904	Smurf1-IN-A01	A01	Others
	Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.		Others
T17879	E3 ligase Ligand 8		Others , Ligand for E3 Ligase
	E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti...		Others , Ligand for E3 Ligase
T22263	Bavdegalutamide	ARV-110	Androgen Receptor
	Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati...		Androgen Receptor
T8488	GMB-475		Bcr-Abl
	GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati...		Bcr-Abl
T16974	TAK-243	MLN7243	Apoptosis , E1/E2/E3 Enzyme , NF-κB
	TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...		Apoptosis , E1/E2/E3 Enzyme , NF-κB
T67834	C004019		Microtubule Associated , PROTACs
	C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C...		Microtubule Associated , PROTACs
T3317	SZL P1-41		Apoptosis , Others , E1/E2/E3 Enzyme
	SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...		Apoptosis , Others , E1/E2/E3 Enzyme
T14896	CC0651		Others
	CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM).		Others
T31834	FMHM
	FMHM is a TRAF6 scavenging agent via ubiquitination-dependent mode.
T25889	NSC-689857	NSC 689857,NSC689857
	NSC-689857 is an inhibitor that acts in the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro.
T69977	BC-1485
	BC-1485 is a first-in-class inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1 ), which disrupts FIEL1-directed PIAS4 ubiquitination.
T70902	AQ-101
	AQ-101 is a inhibitor of MDM2, which induces MDM2 protein degradation through a self-ubiquitination and proteasome-mediated mechanism.
T80686	γ-AA peptide P6
	γ-AA peptide P6 acts as a potent activator of E6 associated protein (E6AP), facilitating both its self-ubiquitination and the ubiquitination of E6AP substrates in vitro reconstituted reactions. Furthermore, γ-AA peptide ...
T25738	Linichlorin A	Elegin
	Linichlorin A is used as a p27(Kip1) ubiquitination inhibitor.
T10345	Apcin-A		Others
	Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.		Others
T34168	PROTAC-I	PROTAC I
	PROTAC-I targets steroid hormone receptors for ubiquitination and degradation.
T69701	HS-152
	HS-152 is a novel reversible inhibitor of smurf1, directly targeting the catalytic activity of smurf hect domains, significantly blocking auto-ubiquitination and the transfer of ubiquitin from hect domain to the substr...
T10875	CP5V		Others
	CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.		Others
T27213	DSHN
	DSHN is a small heterodimer partner (SHP) activator. DSHN transcriptionally activates SHP mRNA, and stabilizes the SHP protein by preventing its ubiquitination and degradation.
T17868	E3 ligase Ligand 10		Others
	E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated d...		Others
T11975	PROTAC Mcl1 degrader-1		BCL
	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 ...		BCL
T17872	E3 ligase Ligand 14		Others
	E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of ca...		Others
T17871	E3 ligase Ligand 13		Others
	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degrad...		Others
T17363	β-Naphthoflavone-CH2-OH	β-NF-CH2-OH	Others
	β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These...		Others
T82632	Cys-C-cGMP		AUTACs
	Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].		AUTACs
T17876	E3 ligase Ligand 18		Others
	E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-me...		Others
T75125	ITK degrader 2
	ITK Degrader 2 (Compound 30) functions as a modulator for targeted ubiquitination and serves as a molecule for targeted protein degradation, specifically degrading ITK [1].
T37646	HB007
	HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for in...
T17880	E3 ligase Ligand 9		Others
	E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of ...		Others
T61776	TEAD-IN-2
	TEAD-IN-2 is an innovative, orally bioavailable inhibitor that targets the transcriptional enhancer associate domain (TEAD). It functions by regulating TEAD through ubiquitination and/or degradation by specific compounds...
T61057	DCeMM4
	dCeMM4 (Compound 5) is a glue degrader that induces cyclin K ubiquitination and degradation through prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex [1].
T37329	PROTAC IDO1 Degrader-1	PROTAC IDO1 Degrader-1
	PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the...
T70096	AEG40730 HCl
	AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in R...

Compounds

Ubiquitination-IN-1

T13244

Synonym:

Target: Others

Ubiquitination-IN-2

Target: Others, IGF-1R

CYM5442

T2026

Synonym:

Target: S1P Receptor, LPL Receptor

TCID

T6697

Synonym: UCH-L3 Inhibitor

Target: DUB

PR-619

T1862

Synonym: PR 619,2,6-Diamino-3,5-dithiocyanopyridine

Target: Apoptosis, DUB, Autophagy

dCeMM3

T9758

Synonym: 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide

Target: Others

ICCB-19 hydrochloride

T8931L

Synonym: ICCB-19 HCl（750621-52-4 free base）

Target: Apoptosis, Others, Autophagy, RIP kinase

GS143

T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

TZ9

T17187

Synonym:

Target: Apoptosis, E1/E2/E3 Enzyme

Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy

Target: Molecular Glues

Target: Others, Ligand for E3 Ligase

Bavdegalutamide

T22263

Synonym: ARV-110

Target: Androgen Receptor

Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB

C004019

T67834

Synonym:

Target: Microtubule Associated, PROTACs

SZL P1-41

T3317

Synonym:

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Synonym: NSC 689857,NSC689857

PROTAC Mcl1 degrader-1

β-Naphthoflavone-CH2-OH

PROTAC IDO1 Degrader-1

T37329

Synonym: PROTAC IDO1 Degrader-1

Cat No.	Product Name	Synonyms	Targets
T4970	LANOSTEROL	3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.		Endogenous Metabolite
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
T6S1780	Protosappanin B	Q-100961,FT-0689654	Apoptosis
	1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, vi...		Apoptosis

Natural Products

LANOSTEROL

T4970

Synonym: 3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol

Target: Endogenous Metabolite

Parthenolide

T2140

Synonym: (-)-Parthenolide

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Protosappanin B

T6S1780

Synonym: Q-100961,FT-0689654

Target: Apoptosis

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02101	KEAP1 Protein, Human, Recombinant (His & GST & Avi)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03432	KEAP1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03888	KEAP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPH-00009	OGT Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc...
TMPY-03357	FGFR2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPY-00972	FGFR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-03235	BST2 Protein, Human, Recombinant (His)	Human	HEK293
	BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPY-00423	FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)	Human	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-02205	Beta-Catenin Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p...
TMPJ-01403	UBE2D4 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-02136	SPSB1 Protein, Human, Recombinant (His)	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Nega...
TMPH-01329	FBXW7 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds pho...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a...
TMPH-01261	NEDD4L Protein, Human, Recombinant (GST)	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig...
TMPH-01569	KLHDC3 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target pr...
TMPJ-00571	UBE2D3 Protein, Human, Recombinant	Human	E. coli
	UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi...
TMPH-03074	UBC5A Protein, Japonica rice, Recombinant (His & Myc)	Rice	E. coli
	E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins.
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and ...
TMPY-02605	UBE2F Protein, Human, Recombinant (His)	Human	E. coli
	UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPH-02847	CNPY2 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
TMPH-01203	DCAF16 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio...
TMPJ-00999	UBE2D1 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPY-02604	UBE2D4 Protein, Human, Recombinant (His)	Human	E. coli
	UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPH-01288	Elongin-B Protein, Human, Recombinant (GST)	Human	E. coli
	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its...
TMPH-01570	KLHDC3 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target pr...
TMPH-01650	PRAME Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a...
TMPH-01651	PRAME Protein, Human, Recombinant (His)	Human	Yeast
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a...
TMPY-03505	COMMD9 Protein, Human, Recombinant (His)	Human	E. coli
	COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discover...
TMPH-01220	DDA1 Protein, Human, Recombinant (His)	Human	E. coli
	Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, ...
TMPH-03508	IpaH9.8 Protein, Shigella flexneri, Recombinant (His)	Shigella flexneri	Yeast
	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute i...
TMPY-02609	UBE2M Protein, Human, Recombinant	Human	E. coli
	UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02607	Ube2H Protein, Human, Recombinant	Human	E. coli
	UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02608	UBC9/UBE2I Protein, Human, Recombinant	Human	E. coli
	UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02606	UBE2G1 Protein, Human, Recombinant	Human	E. coli
	UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-02233	P4HTM Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic...
TMPH-02288	UBE2D3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr...
TMPH-02207	TRAF3 Protein, Human, Recombinant (His)	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon....
TMPH-02630	MDM2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ...
TMPH-02208	TRAF3 Protein, Human, Recombinant	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon....
TMPH-01328	FBXL2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target...
TMPY-03394	RYBP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	APAP-1, also known as AAP1 and RYBP, is widely expressed. It is highest expressed in lymphoid tissues and placenta. APAP-1 contains 1 RanBP2-type zinc finger. It may bind to DNA. APAP-1 inhibits ubiquitination and subseq...
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce...
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KEAP1 Protein, Human, Recombinant (His & GST & Avi)

TMPY-02101

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant

TMPY-03432

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant (His & GST)

TMPY-03888

Species: Human

Expression System: Baculovirus-Insect Cells

OGT Protein, Human, Recombinant (His & SUMO)

TMPH-00009

Species: Human

Expression System: E. coli

FGFR2 Protein, Mouse, Recombinant (hFc)

TMPY-03357

Species: Mouse

Expression System: HEK293

HIST3H2A Protein, Human, Recombinant

TMPY-02521

Species: Human

Expression System: E. coli

FGFR2 Protein, Human, Recombinant (His & hFc)

TMPY-00972

Species: Human

Expression System: HEK293

BST2 Protein, Human, Recombinant (His)

TMPY-03235

Species: Human

Expression System: HEK293

FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)

TMPY-00423

Species: Human

Expression System: HEK293

Beta-Catenin Protein, Human, Recombinant (His & GST)

TMPY-02205

Species: Human

Expression System: Baculovirus-Insect Cells

UBE2D4 Protein, Human, Recombinant (GST)

TMPJ-01403

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

TMPH-01260

Species: Human

Expression System: HEK293

AMFR Protein, Human, Recombinant (His)

TMPH-01259

Species: Human

Expression System: E. coli

SPSB1 Protein, Human, Recombinant (His)

TMPH-02136

Species: Human

Expression System: E. coli

FBXW7 Protein, Human, Recombinant (His)

TMPH-01329

Species: Human

Expression System: in vitro E. coli expression system

TRIP12 Protein, Human, Recombinant (His & Myc)

TMPH-01273

Species: Human

Expression System: E. coli

NEDD4L Protein, Human, Recombinant (GST)

TMPH-01261

Species: Human

Expression System: E. coli

KLHDC3 Protein, Human, Recombinant (His & Myc)

TMPH-01569

Species: Human

Expression System: Baculovirus

UBE2D3 Protein, Human, Recombinant

TMPJ-00571

Species: Human

Expression System: E. coli

UBC5A Protein, Japonica rice, Recombinant (His & Myc)

TMPH-03074

Species: Rice

Expression System: E. coli

Fbxo3 Protein, Mouse, Recombinant (His & Myc)

TMPH-02651

Species: Mouse

Expression System: E. coli

UBE2F Protein, Human, Recombinant (His)

TMPY-02605

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

TMPH-01267

Species: Human

Expression System: E. coli

CNPY2 Protein, Mouse, Recombinant (His & Myc)

TMPH-02847

Species: Mouse

Expression System: E. coli

DCAF16 Protein, Human, Recombinant (His & Myc)

TMPH-01203

Species: Human

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

TMPH-02633

Species: Mouse

Expression System: Baculovirus

WWP2 Protein, Human, Recombinant (His & GST)

TMPY-02950

Species: Human

Expression System: Baculovirus-Insect Cells

UBE2D1 Protein, Human, Recombinant (GST)

TMPJ-00999

Species: Human

Expression System: E. coli

UBE2D4 Protein, Human, Recombinant (His)

TMPY-02604

Species: Human

Expression System: E. coli

Elongin-B Protein, Human, Recombinant (GST)

TMPH-01288

Species: Human

Expression System: E. coli

KLHDC3 Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-01570

Species: Human

Expression System: E. coli

PRAME Protein, Human, Recombinant (E. coli, His)

TMPH-01650

Species: Human

Expression System: E. coli

PRAME Protein, Human, Recombinant (His)

TMPH-01651

Species: Human

Expression System: Yeast

COMMD9 Protein, Human, Recombinant (His)

TMPY-03505

Species: Human

Expression System: E. coli

DDA1 Protein, Human, Recombinant (His)

TMPH-01220

Species: Human

Expression System: E. coli

IpaH9.8 Protein, Shigella flexneri, Recombinant (His)

TMPH-03508

Species: Shigella flexneri

Expression System: Yeast

UBE2M Protein, Human, Recombinant

TMPY-02609

Species: Human

Expression System: E. coli

Ube2H Protein, Human, Recombinant

TMPY-02607

Species: Human

Expression System: E. coli

UBC9/UBE2I Protein, Human, Recombinant

TMPY-02608

Species: Human

Expression System: E. coli

UBE2G1 Protein, Human, Recombinant

TMPY-02606

Species: Human

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

TMPH-02632

Species: Mouse

Expression System: E. coli

P4HTM Protein, Human, Recombinant (His & SUMO)

TMPH-02233

Species: Human

Expression System: E. coli

UBE2D3 Protein, Human, Recombinant (His & SUMO)

TMPH-02288

Species: Human

Expression System: E. coli

SKP2 Protein, Human, Recombinant (His & SUMO)

TMPH-02131

Species: Human

Expression System: E. coli

TRAF3 Protein, Human, Recombinant (His)

TMPH-02207

Species: Human

Expression System: E. coli

MDM2 Protein, Mouse, Recombinant (His)

TMPH-02630

Species: Mouse

Expression System: E. coli

TRAF3 Protein, Human, Recombinant

TMPH-02208

Species: Human

Expression System: E. coli

FBXL2 Protein, Human, Recombinant (His & SUMO)

TMPH-01328

Species: Human

Expression System: E. coli

RYBP Protein, Human, Recombinant (His & GST)

TMPY-03394

Species: Human

Expression System: Baculovirus-Insect Cells

Pellino-1 Protein, Human, Recombinant (His & GST)

TMPY-00361

Species: Human

Expression System: Baculovirus-Insect Cells

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Cat No.	Product Name
L8600	Ubiquitination Compound Library	214 compounds
	A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；
L8500	HIF-1 Signaling Pathway Compound Library	1352 compounds
	A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L3800	NF-κB Signaling Compound Library	740 compounds
	A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;

Libraries

Ubiquitination Compound Library

L8600

Compounds: 214

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1352

NF-κB Signaling Compound Library

L3800

Compounds: 740