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NTRK degrader-1
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Catalog No. T217904 Copy Product Info
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NTRK degrader-1 is a PROTAC degrader and kinase inhibitor targeting both wild-type and mutant (G595R, G667C, F598L) NTRK1. It exhibits IC50 values of 4 nM for wild-type, 2 nM for G595R, 5 nM for G667C, and <0.5 nM for F598L mutations. This compound facilitates the ubiquitination and subsequent proteasomal degradation of wild-type and mutant (G595R, G667C, F598L) NTRK1. NTRK degrader-1 is applicable in the study of solid tumors.
NTRK degrader-1
Cas No. 2922274-35-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NTRK degrader-1 is a PROTAC degrader and kinase inhibitor targeting both wild-type and mutant (G595R, G667C, F598L) NTRK1. It exhibits IC50 values of 4 nM for wild-type, 2 nM for G595R, 5 nM for G667C, and <0.5 nM for F598L mutations. This compound facilitates the ubiquitination and subsequent proteasomal degradation of wild-type and mutant (G595R, G667C, F598L) NTRK1. NTRK degrader-1 is applicable in the study of solid tumors. |
| In vitro | NTRK degrader-1 (compound 5b) degrades wild-type NTRK1, NTRK1 G595R, NTRK1 G667C, and NTRK1 F598L in 293 T cells within 6 hours, with inflection point (IP) values of 0.2 nM, 1 nM, 2 nM, and 0.2 nM, respectively. It inhibits these same variants, with IC50 values of 4 nM, 2 nM, 5 nM, and <0.5 nM, respectively. |
| Molecular Weight | 746.75 |
| Formula | C38H35FN10O6 |
| Cas No. | 2922274-35-7 |
| Smiles | O=C1NC2=CC=C(C=C2OC3=CC=C(F)C=C3CN=C4C=CN5N=CC1=C5N4)C(=O)NCC(=O)N6CCN(C7=CC=C(C=C7)NC8C(=O)NC(=O)CC8)CC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: NTRK degrader-1 in vitro | NTRK degrader-1 formula | NTRK degrader-1 molecular weight
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