ikr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2712	Nifekalant hydrochloride		Potassium Channel
	Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM. It is a Class III antiarrhythmic compound and can be used in the study of tachyarrhythmias.		Potassium Channel
T3574	Sematilide hydrochloride	CK-1752A,CK-1752,Sematilide HCl	Potassium Channel
	Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the ...		Potassium Channel
T73611	Kallikrein
	Kallikrein is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides , respectively [1] .
T40312	Plasma kallikrein-IN-1
	Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
T63796	Kallikrein-IN-2
	Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.
T72337	Plasma kallikrein-IN-2
	Plasma kallikrein-IN-2, a potent inhibitor of plasma kallikrein (PKal) with an inhibitory concentration (IC) 50 value of 0.1 nM, is utilized in research targeting hereditary angioedema, diabetic macular edema, and diabet...
T63579	Kallikrein-IN-1
	Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.
T61403	Plasma kallikrein-IN-3
	Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].
T72624	Kallikrein 5-IN-2
	Kallikrein 5-IN-2 is a potent inhibitor of Kallikrein KLK5, exhibiting selectivity with a pIC50 value of 7.1. By inhibiting KLK5, it has the potential to normalize epidermal shedding, thereby reducing associated inflamma...
T30251	AZD-1305	UNII-CZO834LXQM,AZD 1305	Others
	AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in st...		Others
T23536	Xamoterol hemifumarate	ICI 118587 hemifumarate,Corwin hemifumarate	Adrenergic Receptor
	Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr...		Adrenergic Receptor
T7505	Azimilide Dihydrochloride	NE-10064 Dihydrochloride	Potassium Channel
	Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current		Potassium Channel
T16347	NS3623		Potassium Channel
	NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e...		Potassium Channel
T6476	Dofetilide	UK 68789,UK-68798,Tikosyn	Potassium Channel
	Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik...		Potassium Channel
T6633	Ranolazine	CVT 303,Ranexa,RS 43285-003	Calcium Channel , Sodium Channel
	Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the...		Calcium Channel , Sodium Channel
T0207	Ranolazine dihydrochloride	RS 43285,Ranolazine 2HCl	Calcium Channel , Sodium Channel , Autophagy
	Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or h...		Calcium Channel , Sodium Channel , Autophagy
TP1858L	Phe-Met-Arg-Phe, amide acetate	Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)	Potassium Channel
	Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.		Potassium Channel
T12879	Sematilide	CK-1752	Others
	Sematilide is a blocker of selective IKr channel.		Others
T14189	Almokalant	H 234/09	Potassium Channel
	Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.		Potassium Channel
T72323	Antiarrhythmic agent-1
	Antiarrhythmic agent-1 (example I), functioning as an antiarrhythmic agent and an IKr potassium channel blocker (IC 50 <1 μM), effectively inhibits cardiac arrhythmias.