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Carbonic Anhydrase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    203
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    1
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    1
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    TargetMol | Inhibitors_Agonists
Carbonic anhydrase inhibitor 12
T721222883451-38-3
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anticancer activity across various cancer cell lines [1].
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8-10 weeks
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Carbonic anhydrase inhibitor 15
T78840
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].
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alp/carbonic anhydrase-in-1
T831372091887-74-8
Compound 1e, also known as ALP Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline phosphatase (ALP). It exhibits inhibitory IC50 values of 0.44 µM for CA-II, 1.61 µM for CA-IX, 0.51 µM for CA-XII, and 0.107 µM for ALP [1].
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8-10 weeks
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Enpp/Carbonic anhydrase-IN-1
T677752883495-35-8
Enpp Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase, exhibiting IC50s of 1.36, 1.35, 3.00, 0.88, and 1.02 µM for NPP1, NPP2, NPP3, CA-II, and CA-IX respectively. Enpp Carbonic anhydrase-IN-1 also demonstrates selective antiproliferative activity for cancer cells.
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Carbonic anhydrase
T760139001-03-0
Carbonic anhydrase is a ubiquitous, zinc-containing metalloenzyme found in both prokaryotes and eukaryotes. It catalyzes the reversible conversion of carbon dioxide to bicarbonate and protons and can be used for research in cancer, glaucoma, obesity, and epilepsy [1] [2].
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Enpp/Carbonic anhydrase-IN-2
T776312883495-39-2
Enpp Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp Carbonic anhydrase-IN-2 induced apoptosis.Enpp Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
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Sultiame
T1696061-56-3In house
Sultiame is an inhibitor of carbonic anhydrase. Sultiame can be used in antiepileptic research.
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6-8 weeks
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Ellagic acid
Gallogen, Elagostasine
T0465476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity.
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Acetazolamide
Diamox
T081359-66-5
Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.
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Mafenide hydrochloride
4-Aminomethylbenzenesulfonamide hydrochloride
T1026138-37-4
Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
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Methocarbamol
Robaxin, Metocarbamol, Lumirelax, AHR 85
T1409532-03-6
Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
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Orthanilamide
O-Sulfanilamide, Benzenesulfonamide, 2-Aminobenzenesulfonamide
T21873306-62-5
Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.
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Acetazolamide sodium
OT-302 sodium
T603511424-27-7
Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness.
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6-8 weeks
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Histone acetyltransferase p300 Inhibitor 4c
T775602103-99-3
Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 µM. 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM.
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Methyl 2,4-dihydroxybenzoate
TN67072150-47-2
Methyl 2,4-dihydroxybenzoate is a natural product.
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2,3-dihydro-1H-indene-5-sulfonamide
T861135203-93-1
2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
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Chlorothiazide
Diuril, Chlotride, Chlorothiazid
T067758-94-6
Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.
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Bendroflumethiazide
Naturetin, Aprinox
T120473-48-3
Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
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TSPO/Carbonic Anhydrase Modulator 1
T204394
TSPO Carbonic Anhydrase Modulator 1 (Compound 3) acts as a dual modulator of mitochondrial translocator protein and carbonic anhydrase, with a TSPOKi of 1.340 μM and a CAVII KA of 10.7 μM. It enhances neurosteroid production, increases BDNF gene expression, and demonstrates neuroprotective activity.
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pik-93
PIK 93
T2616593960-11-3
PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3Kα with an IC50 of 39 nM.
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Dimethylfraxetin
Fraxetin dimethyl ether, 6,7,8-Trimethoxycoumarin
T4S23546035-49-0
Dimethylfraxetin (6,7,8-Trimethoxycoumarin) is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
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hCAIX-IN-16
T730282849348-38-3
hCAIX-IN-16 (Compound 12d), an inhibitor of hCA IX, exhibits inhibition constants (K i) of 190.0 nM for hCA IX and 187.9 nM for hCA XII. It can arrest the cell cycle in the G0-G1 and S phases and induce apoptosis in MDA-MB-468 breast cancer cells. Demonstrating broad-spectrum anticancer activity, hCAIX-IN-16 is a potential tool for cancer research [1].
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8-10 weeks
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hCAIX-IN-15
T730292849348-43-0
hCAIX-IN-15, a potent inhibitor of human carbonic anhydrase IX (hCA IX), has an inhibition constant (Ki) of 38.8 nM and exhibits broad-spectrum anticancer activity suitable for cancer research [1].
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8-10 weeks
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Girentuximab
WX-G250, G250, cG250
T76684916138-87-9
Girentuximab (G250) is a potent anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anticancer activity for the study of uroepithelial carcinoma PET (ZiPUP).
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