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PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10299 AMG PERK 44 1883548-84-2 98%
AMG PERK 44
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) that induces autophagy.AMG PERK 44 inhibits GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 ...
T3881 Vaccarin 53452-16-7 99.97%
Vaccarin
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
T3045 Salubrinal 405060-95-9 99.97%
Salubrinal
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T2027 ISRIB 548470-11-7 99.93%
ISRIB
ISRIB is a potent and selective PERK inhibitor.
T2654 GSK2656157 1337532-29-2 99.89%
GSK2656157
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T5173 SBI-0640756 1821280-29-8 99.83%
SBI-0640756
SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
T3207 Briciclib 865783-99-9 99.82%
Briciclib
Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.
T72053 PERK-IN-6 1337532-14-5 99.78%
PERK-IN-6
PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).
T4304 Azoramide 932986-18-0 99.71%
Azoramide
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
T41231 GP 1a 511532-96-0 99.44%
GP 1a
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold m...
T73053 BAY 2965501 2732902-08-6 99.4%
BAY 2965501
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.
T1742 4E1rcat 328998-25-0 99.36%
4E1rcat
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T2665 4EGI-1 315706-13-9 99.12%
4EGI-1
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T77499 MSU-42011 2456434-36-7 99.04%
MSU-42011
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T6183 ISRIB (trans-isomer) 1597403-47-8 98.81%
ISRIB (trans-isomer)
ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T3564 SHP099 1801747-42-1 98.73%
SHP099
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells ...
T2614 GSK2606414 1337531-36-8 98.62%
GSK2606414
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
T7150 BTdCPU 1257423-87-2 98.61%
BTdCPU
BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T2417 Sal003 1164470-53-4 98.58%
Sal003
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
TQ0131 Rocaglamide 84573-16-0 98.46%
Rocaglamide
Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of N...
AMG PERK 44
T10299
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) that induces autophagy.AMG PERK 44 inhibits GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 ...
Vaccarin
T3881
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
Salubrinal
T3045
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
ISRIB
T2027
ISRIB is a potent and selective PERK inhibitor.
GSK2656157
T2654
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
SBI-0640756
T5173
SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
Briciclib
T3207
Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.
PERK-IN-6
T72053
PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).
Azoramide
T4304
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
GP 1a
T41231
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold m...
BAY 2965501
T73053
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.
4E1rcat
T1742
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
4EGI-1
T2665
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
MSU-42011
T77499
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
ISRIB (trans-isomer)
T6183
ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
SHP099
T3564
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells ...
GSK2606414
T2614
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
BTdCPU
T7150
BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
Sal003
T2417
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
Rocaglamide
TQ0131
Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of N...
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TargetMol