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Apoptosis PERK

PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.
Cat No. product name
TQ0131 Rocaglamide Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB ac...
T7150 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T5173 SBI0640756 SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
T4304 Azoramide Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
T3045 Salubrinal Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T1742 4E1rcat 4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T2665 4EGI1 4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T6183 ISRIB (trans-isomer) ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T2654 GSK2656157 GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T2614 GSK2606414 GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
T2417 Sal003 Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
Rocaglamide
TQ0131CAS 84573-16-0
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB ac...
BTdCPU
T7150CAS 1257423-87-2
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
SBI0640756
T5173CAS 1821280-29-8
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
Azoramide
T4304CAS 932986-18-0
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
Salubrinal
T3045CAS 405060-95-9
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
4E1rcat
T1742CAS 328998-25-0
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
4EGI1
T2665CAS 315706-13-9
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
ISRIB (trans-isomer)
T6183CAS 1597403-47-8
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
GSK2656157
T2654CAS 1337532-29-2
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
GSK2606414
T2614CAS 1337531-36-8
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
Sal003
T2417CAS 1164470-53-4
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.