T73053 |
BAY 2965501
|
2732902-08-6
|
98%
|
|
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.
|
T14044 |
4E2RCat
|
432499-63-3
|
98%
|
|
4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).
|
T9149 |
2BAct
|
2143542-28-1
|
98%
|
|
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
|
T2614 |
GSK2606414
|
1337531-36-8
|
98%
|
|
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
|
T14902 |
CCT020312
|
324759-76-4
|
98%
|
|
CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.
|
T7150 |
BTdCPU
|
1257423-87-2
|
98%
|
|
BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
|
T3564 |
SHP099
|
1801747-42-1
|
98%
|
|
SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). S...
|
T77499 |
MSU-42011
|
2456434-36-7
|
98%
|
|
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
|
T2665 |
4EGI-1
|
315706-13-9
|
98%
|
|
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
|
T6183 |
ISRIB (trans-isomer)
|
1597403-47-8
|
98%
|
|
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
|
T1742 |
4E1rcat
|
328998-25-0
|
98%
|
|
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
|
T41231 |
GP 1a
|
511532-96-0
|
98%
|
|
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold m...
|
T2417 |
Sal003
|
1164470-53-4
|
98%
|
|
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
|
T3207 |
Briciclib
|
865783-99-9
|
98%
|
|
Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
|
T5173 |
SBI-0640756
|
1821280-29-8
|
98%
|
|
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
|
T4304 |
Azoramide
|
932986-18-0
|
98%
|
|
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
|
T2654 |
GSK2656157
|
1337532-29-2
|
98%
|
|
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
|
T2027 |
ISRIB
|
548470-11-7
|
98%
|
|
ISRIB is a potent and selective PERK inhibitor.
|
T3045 |
Salubrinal
|
405060-95-9
|
98%
|
|
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
|
T3881 |
Vaccarin
|
53452-16-7
|
98%
|
|
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
|