me 2

H3K27(Me2) (15-34) is a histone peptide originating from human histones, known as an inhibitory chromatin marker. The Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).

Fmoc-Lys(Me2)-OH.HCl is an amino acid derivative and has a wide range of applications in life science related research.

GSK-J4 (GSK J4 HCl) is a cell permeable prodrug of GSK-J1, a dual inhibitor of the H3K27me3/me2 demethylases JMJD3/KDM6B and UTX/KDM6A (IC50=8.6/6.6 μM). GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.

5'-O-DMT-N6-Me-2'-dA is a nucleoside that exhibits protective and modification effects.

2'-O-Me-2-thio-U-3'-phos phoramidite is a Nucleoside Phosphoramidite.

DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite is a monomeric material utilized in the synthesis of nucleic acids.

DMTr-S-5-C-Me-2'-F-dA(Bz)-3'-CE-phosphoramidite is a monomeric raw material utilized in nucleic acid synthesis.

DMTr-S-5-C-Me-2'-O-Me-rU-3'-CE-phosphoramidite serves as a monomeric building block for nucleic acid synthesis.

DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite is a monomeric material utilized in the synthesis of nucleic acids.

DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is a monomeric material utilized in the synthesis of nucleic acids.

NSD2/H3K36me2 modulator-1 is an orally active modulator targeting NSD2/H3K36me2. It competitively binds to the SAM pocket of NSD2, effectively inhibiting NSD2 expression and H3K36me2 methylation. This compound can also reverse epithelial-mesenchymal transition (EMT), inhibit cell migration, and induce G0/G1 phase arrest and apoptosis (apoptosis). Additionally, NSD2/H3K36me2 modulator-1 reduces mitochondrial membrane potential (MMP) and promotes reactive oxygen species (ROS) generation. It is used in research for developing epigenetic anticancer strategies targeting NSD2 in hepatocellular carcinoma (HCC).

Olpadronic acid is a biochemical.

GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.

N-Me-N-bis(PEG2-propargyl) is a PEG-based linker used in the synthesis of PROTACs [1].

NO2-SPP-sulfo-Me is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC)[1].

NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based compound used in the synthesis of PROTACs [1].

[Ru(phen)2(4-Me-Sal)]BF4 (compound 10) is an Ru(II)-based polypyridyl complex that exhibits remarkable antiproliferative activity against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, with IC50 values of 0.52 μM and 5.56 μM, respectively.

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid-glu(PEG24-Me)-val-cit-NH-benzyloxyformic acid-MMAE is a component of a drug-linker conjugate for ADC. It includes a linker and a biologically active small molecule toxin, MMAE. This compound can conjugate with NN2101 (anti-c-Kit) to form NN3201, which rapidly internalizes and inhibits SCF-driven signal transduction, inducing cell cycle arrest and apoptosis through payload delivery. NN3201 exhibits significant c-Kit-dependent antitumor activity in various tumor models, such as small cell lung cancer (SCLC) and gastrointestinal stromal tumors (GIST).

Dihydrouracil-Ph-2-Me-piperidine is an E3 ligase ligand used in the synthesis of [PROTACHPK1 Degrader-6].

Epac activator

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.

2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer utilized in oligonucleotide synthesis.

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable linker used in ADC synthesis for conjugation with antibodies, ultimately yielding antibody-drug conjugates (ADCs).