me 2

H3K27(Me2) (15-34) is a histone peptide originating from human histones, known as an inhibitory chromatin marker. The Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).

Fmoc-Lys(Me2)-OH.HCl is an amino acid derivative and has a wide range of applications in life science related research.

GSK-J4 (GSK J4 HCl) is a cell permeable prodrug of GSK-J1, a dual inhibitor of the H3K27me3/me2 demethylases JMJD3/KDM6B and UTX/KDM6A (IC50=8.6/6.6 μM). GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.

5'-O-DMT-N6-Me-2'-dA is a nucleoside that exhibits protective and modification effects.

2'-O-Me-2-thio-U-3'-phos phoramidite is a Nucleoside Phosphoramidite.

Olpadronic acid is a biochemical.

GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.

N-Me-N-bis(PEG2-propargyl) is a PEG-based linker used in the synthesis of PROTACs [1].

NO2-SPP-sulfo-Me is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC)[1].

NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based compound used in the synthesis of PROTACs [1].

[Ru(phen)2(4-Me-Sal)]BF4 (compound 10) is an Ru(II)-based polypyridyl complex that exhibits remarkable antiproliferative activity against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, with IC50 values of 0.52 μM and 5.56 μM, respectively.

Epac activator

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.

2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer utilized in oligonucleotide synthesis.

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable linker used in ADC synthesis for conjugation with antibodies, ultimately yielding antibody-drug conjugates (ADCs).

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthetic E3 ligase ligand-linker conjugate composed of a VHL ligand and a linker, utilized in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3.

Boc-Phe(2-Me)-OH is an amino acid derivative and has a wide range of applications in life science related research.

Boc-D-Phe(2-Me)-OH, an amino acid derivative, has diverse applications in life science research.

H-Phe(2-Me)-OH is a valuable organic compound for life sciences research, catalog number T66208.

2'-O-Me-5-I-U-3'-phosphoramidite, a purine nucleoside analog, exhibits extensive antitumor activity primarily against indolent lymphoid malignancies through mechanisms such as DNA synthesis inhibition and apoptosis induction, among others [1].

(D(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, serving as an oxytocin receptor antagonist, effectively nullifies the augmentation of inhibitory postsynaptic currents in CA1 pyramidal neurons by oxytocin [1].

(d(CH2)51,Tyr(Me)2, Orn8)-Oxytocin (OVT) is an oxytocin receptor antagonist used in neurological disease research [1].

(d(CH2)5[Tyr(Me)2, Dab5]AVP), a vasopressin V1a receptor-specific antagonist, demonstrates a pA2 value of 6.71 [1].