coumarin

Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.

5,7-Dihydroxycoumarin, a coumarin isolated from the inflorescences of Macaranga triloba, exhibits antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. Fitoterapia. 2012 Jul;83(5):968-72. [2]. Yi-Ping Chin, et al. Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives. Arch Pharm (Weinheim). 2011 Jun;344(6):386-93.

7-Methylcoumarin with strong hepatoprotective activity.

Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.

Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.

Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.

1. Notopterol induces apoptosis and inhibits cell cycle-specific.

Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, significantly induces the differentiation of HL-60 cells.

Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activities.

Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1 2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.

6,7-Bis(benzyloxy)coumarin is a useful organic compound for research related to life sciences. The catalog number is T123943 and the CAS number is 909-84-2.

Coumarin (Standard) is the standard substance of Coumarin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.

7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6207 and the CAS number is 118584-19-3.

7-(3'-Carboxybutoxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6209 and the CAS number is 16851-01-7.

etunidin 3-Rutinoside(Cis-p-coumarin)glucoside-5-glucoside is a natural product that can be used in related research in the field of life sciences. Its product number is TN8593.

4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.

4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.

6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.

3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes.

4-Methoxycoumarine has antitumour effects.

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.

4-Methyl-6-Methoxycoumarin is a natural product isolated from Eupatorium pauciflorum.