coumarin

Coumarin is a chemical compound poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.

7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.

Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1 2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.

Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activities.

The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR VEGFR2 c-Met-Akt-NF-κB signaling pathways; this combination may have a wide therapeutic and or adjuvant therapeutic application in the treatment of lung cancer.

7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.

Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.

7-(3'-Carboxybutoxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6209 and the CAS number is 16851-01-7.

6,7-Bis(benzyloxy)coumarin is a useful organic compound for research related to life sciences. The catalog number is T123943 and the CAS number is 909-84-2.

Coumarin 7 is a natural product.

Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, significantly induces the differentiation of HL-60 cells.

etunidin 3-Rutinoside(Cis-p-coumarin)glucoside-5-glucoside is a natural product that can be used in related research in the field of life sciences. Its product number is TN8593.

7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6207 and the CAS number is 118584-19-3.

4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.

6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.

3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes.

4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.

7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.

4-Methoxycoumarine has antitumour effects.

4-Ethoxycoumarin has antimicrobial activity.

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

4-Methyl-6-Methoxycoumarin is a natural product isolated from Eupatorium pauciflorum.

Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

5-Geranoxy-7-methoxycoumarin shows antifungal activity.