coumarin

Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm

Coumarin 478 is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 10.7 and 27.8 µ M, respectively.

Coumarin-6-sulfonyl chloride is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

5,7-Dihydroxycoumarin, a coumarin isolated from the inflorescences of Macaranga triloba, exhibits antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. Fitoterapia. 2012 Jul;83(5):968-72. [2]. Yi-Ping Chin, et al. Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives. Arch Pharm (Weinheim). 2011 Jun;344(6):386-93.

7-Methylcoumarin with strong hepatoprotective activity.

The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/VEGFR2/c-Met-Akt-NF-κB signaling pathways; this combination may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of lung cancer.

7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.

3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes.

Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.

7-Amino-4-methylcoumarin-3-acetic acid [7-Amino-4-methylcoumarin] is a more suitable substrate for enteropeptidase compared to GD(4)K-NA.

Ethyl coumarin-3-carboxylate, a coumarin derivative, serves as a pseudo-template for the synthesis of Molecularly Imprinted Polymers (MIPs) that specifically recognize aflatoxins.

Coumarin-d4 (Standard) is the standard substance of Coumarin-d4, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Coumarin-d4 is a deuterated compound of Coumarin. Coumarin has a CAS number of 91-64-5. Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.

Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.

Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.

Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.

1. Notopterol induces apoptosis and inhibits cell cycle-specific.

Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, significantly induces the differentiation of HL-60 cells.

Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activities.

Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.

Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a marked inhibitory effect on S.aureus proliferation. It increased the level of Nrf2/ARE, and HO-1, inhibit the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax.

Coumarin–quinone conjugate, a fluorescent substrate for NADH:ubiquinone oxidoreductases, consists of a coumarin fluorophore and a ubiquinone analog. It can be utilized to measure the kinetic parameters of AIFM2/FSP1 in research related to ferroptosis [1].

Zidovudine-d3 is the deuterated form of Zidovudine and can be used for isotope tracing.

7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.