anti-hiv

Anti-HIV gp120 Antibody (55-36) is a chimeric mouse IgG1 κ antibody designed to target HIV gp120. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

Ibalizumab(TMB-355) is a humanized IgG4 monoclonal antibody that acts as a CD4 receptor inhibitor, blocking the entry of HIV-1 into cells by binding to the CD4 receptor.Ibalizumab has anti-HIV-1 infectious activity and may be used to maintain normal immune function.

Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.

Anti-CXCR4/CD184 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human C-X-C chemokine receptor type 4 (CXCR4) with exceptional binding affinity. It effectively facilitates the measurable blockade of the CXCL12/CXCR4 signaling axis across various preclinical experimental models to evaluate the modulation of cellular chemotaxis, hematopoietic stem cell mobilization, and the inhibition of tumor metastasis during strictly monitored laboratory observation periods and functional cell migration assays.

Anti-CD4 Antibody (TRX1) is a humanized, non-depleting monoclonal antibody targeting the CD4 receptor. The compound specifically binds to CD4 on T helper cells, inducing receptor down-modulation and T-cell anergy to establish immune tolerance without causing significant depletion of CD4+ T cells. It is utilized in clinical and experimental research for tolerance induction in autoimmune diseases and as an HIV entry inhibitor.

Anti-DC-SIGN/CD209 Antibody is a specific monoclonal antibody targeting DC-SIGN (CD209). As a C-type lectin primarily expressed on the surface of dendritic cells, DC-SIGN is involved in pathogen recognition and the regulation of immune responses. This antibody is widely applied to study mechanisms of viral trans-infection (e.g., HIV-1), antigen presentation processes, and the development of dendritic cell-targeted vaccines.

Anti-CTLA-4/CD152 Antibody (BN13) is a mouse chimeric inhibitory antibody that specifically binds to human CTLA-4/CD152.Anti-CTLA-4/CD152 Antibody (BN13) can neutralize CTLA-4 (CD152) and is applicable to studies on infection and immunology, such as human immunodeficiency virus (HIV)-related research .

HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is a monoclonal antibody targeting mouse/human/rat CCL2/MCP-1, capable of blocking the CCL2 signalling pathway, reversing the immunosuppressive microenvironment, enhancing chemotherapy sensitivity, reducing macrophage infiltration, and inhibiting latent HIV seeding. It is applicable for studying inflammatory diseases, viral infections, and cancers such as inflammatory bowel disease (IBD) and hepatocellular carcinoma (HCC).