Raf

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases.

Cat. No.	Product name	CAS No.	Purity
T1931	6H05	1469338-01-9	99.02%
T1931	6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
T67862	B-Raf IN 13	2573782-74-6	98.39%
T67862	B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
TN3920	Effusanin A	30220-43-0	98.00%
TN3920	Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) ye...
T12556	PROTAC B-Raf degrader 1	2364367-27-9	98%
T12556	PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
T78777	Vem-L-Cy5		98%
T78777	Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF V600...
T79813	Raf inhibitor 3	1662682-11-2	98%
T79813	Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].
T82637	Cyclorasin 9A5	1782098-79-6	98%
T82637	Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibition concentr...
TN2114	Pseudoginsenoside Rh2	1370264-16-6	98%
TN2114	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
T8721	I-37	2359690-13-2	98%
T8721	I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) is a novel benzylamino sub...
TN4166	Griffipavixanthone	219649-95-3	98%
TN4166	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
T15804	LY2452473	1029692-15-6	98%
T15804	LY2452473 is an orally bioavailable and selective androgen receptor modulator.
T12978	NSC-70220	4551-00-2	98%
T12978	SOS1-IN-1 is an inhibitor of SOS1.
T10567	BMS-214662	195987-41-8	98%
T10567	BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem c...
T13406L	Zabofloxacin hydrochloride	623574-00-5	98%
T13406L	Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
T8654	Plx-4032	1029872-54-5	99.94%
T8654	Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
T11898	LXH254	1800398-38-2	99.92%
T11898	LXH254 is a potent C-Raf and B-Raf inhibitor.
T4301	AD80	1384071-99-1	99.9%
T4301	AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
T16909	Sorafenib-d3	1130115-44-4	99.88%
T16909	Sorafenib-d3 (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, re...
T1792	Regorafenib	755037-03-7	99.87%
T1792	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
T8823	Locostatin	133812-16-5	99.84%
T8823	Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.