Raf

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases.

Cat. No.	Product name	CAS No.	Purity
T1931	6H05	1469338-01-9	99.02%
T1931	6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
T67862	B-Raf IN 13	2573782-74-6	95.83%
T67862	B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
T12556	PROTAC B-Raf degrader 1	2364367-27-9	98%
T12556	PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
TN2114	Pseudoginsenoside Rh2	1370264-16-6	98%
TN2114	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
T8721	I-37	2359690-13-2	98%
T8721	I-37 is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.
TN4166	Griffipavixanthone	219649-95-3	98%
TN4166	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
T15804	LY2452473	1029692-15-6	98%
T15804	LY2452473 is an orally bioavailable and selective androgen receptor modulator.
T12978	NSC-70220	4551-00-2	98%
T12978	SOS1-IN-1 is an inhibitor of SOS1.
T10567	BMS-214662	195987-41-8	98%
T10567	BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem c...
T13406L	Zabofloxacin hydrochloride	623574-00-5	98%
T13406L	Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
T4301	AD80	1384071-99-1	99.9%
T4301	AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
T2473	PLX-4720	918505-84-7	99.89%
T2473	PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).
T16909	Sorafenib-d3	1130115-44-4	99.88%
T16909	Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
T1792	Regorafenib	755037-03-7	99.87%
T1792	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
T2327	Pelitinib	257933-82-7	99.86%
T2327	Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T8823	Locostatin	133812-16-5	99.84%
T8823	Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
T5172	AZ304	942507-42-8	99.83%
T5172	AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
T0093	Sorafenib tosylate	475207-59-1	99.81%
T0093	Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T6895	TAK-580	1096708-71-2	99.77%
T6895	MLN2480 is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.
T2624	OSI-930	728033-96-3	99.76%
T2624	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...