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Raf

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases.
Cat. No. Product name CAS No. Purity Chemical Structure
T1931 6H05 1469338-01-9 99.02%
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
T67862 B-Raf IN 13 2573782-74-6 95.83%
B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
T12556 PROTAC B-Raf degrader 1 2364367-27-9 98%
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
TN2114 Pseudoginsenoside Rh2 1370264-16-6 98%
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
T8721 I-37 2359690-13-2 98%
I-37 is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.
TN4166 Griffipavixanthone 219649-95-3 98%
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
T15804 LY2452473 1029692-15-6 98%
LY2452473 is an orally bioavailable and selective androgen receptor modulator.
T12978 NSC-70220 4551-00-2 98%
SOS1-IN-1 is an inhibitor of SOS1.
T10567 BMS-214662 195987-41-8 98%
BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem c...
T13406L Zabofloxacin hydrochloride 623574-00-5 98%
Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
T4301 AD80 1384071-99-1 99.9%
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
T2473 PLX-4720 918505-84-7 99.89%
PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).
T16909 Sorafenib-d3 1130115-44-4 99.88%
Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
T1792 Regorafenib 755037-03-7 99.87%
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
T2327 Pelitinib 257933-82-7 99.86%
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T8823 Locostatin 133812-16-5 99.84%
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
T5172 AZ304 942507-42-8 99.83%
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
T0093 Sorafenib tosylate 475207-59-1 99.81%
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T6895 TAK-580 1096708-71-2 99.77%
MLN2480 is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.
T2624 OSI-930 728033-96-3 99.76%
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
6H05
T1931
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
B-Raf IN 13
T67862
B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
PROTAC B-Raf degrader 1
T12556
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
Pseudoginsenoside Rh2
TN2114
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
I-37
T8721
I-37 is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.
Griffipavixanthone
TN4166
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
LY2452473
T15804
LY2452473 is an orally bioavailable and selective androgen receptor modulator.
NSC-70220
T12978
SOS1-IN-1 is an inhibitor of SOS1.
BMS-214662
T10567
BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem c...
Zabofloxacin hydrochloride
T13406L
Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
AD80
T4301
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
PLX-4720
T2473
PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).
Sorafenib-d3
T16909
Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
Regorafenib
T1792
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
Pelitinib
T2327
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
Locostatin
T8823
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
AZ304
T5172
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
Sorafenib tosylate
T0093
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
TAK-580
T6895
MLN2480 is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.
OSI-930
T2624
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
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