T1931 |
6H05
|
1469338-01-9
|
99.02%
|
|
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
|
T67862 |
B-Raf IN 13
|
2573782-74-6
|
95.83%
|
|
B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
|
T12556 |
PROTAC B-Raf degrader 1
|
2364367-27-9
|
98%
|
|
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
|
TN2114 |
Pseudoginsenoside Rh2
|
1370264-16-6
|
98%
|
|
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
|
T8721 |
I-37
|
2359690-13-2
|
98%
|
|
I-37 is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.
|
TN4166 |
Griffipavixanthone
|
219649-95-3
|
98%
|
|
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
|
T15804 |
LY2452473
|
1029692-15-6
|
98%
|
|
LY2452473 is an orally bioavailable and selective androgen receptor modulator.
|
T12978 |
NSC-70220
|
4551-00-2
|
98%
|
|
SOS1-IN-1 is an inhibitor of SOS1.
|
T10567 |
BMS-214662
|
195987-41-8
|
98%
|
|
BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem c...
|
T13406L |
Zabofloxacin hydrochloride
|
623574-00-5
|
98%
|
|
Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
|
T4301 |
AD80
|
1384071-99-1
|
99.9%
|
|
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
|
T2473 |
PLX-4720
|
918505-84-7
|
99.89%
|
|
PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).
|
T16909 |
Sorafenib-d3
|
1130115-44-4
|
99.88%
|
|
Sorafenib-d3 is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
|
T1792 |
Regorafenib
|
755037-03-7
|
99.87%
|
|
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5/2.5/4.2/7/13/22 nM for RET/C-RAF/VEGFR2/c-Kit/VEGFR1/PDGFRβ).
|
T2327 |
Pelitinib
|
257933-82-7
|
99.86%
|
|
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
|
T8823 |
Locostatin
|
133812-16-5
|
99.84%
|
|
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
|
T5172 |
AZ304
|
942507-42-8
|
99.83%
|
|
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
|
T0093 |
Sorafenib tosylate
|
475207-59-1
|
99.81%
|
|
Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
|
T6895 |
TAK-580
|
1096708-71-2
|
99.77%
|
|
MLN2480 is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.
|
T2624 |
OSI-930
|
728033-96-3
|
99.76%
|
|
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
|