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Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10960L Darbufelone mesylate 139340-56-0 96.81%
Darbufelone mesylate
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 ...
T2573 Misoprostol 59122-46-2
Misoprostol
Misoprostol is a useful organic compound for research related to life sciences. The catalog number is T2573 and the CAS number is 59122-46-2.
T3P2855 Chamigrenal 19912-84-6
Chamigrenal
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO producti...
TN4592 Murrangatin 37126-91-3 98%
Murrangatin
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN5248 Voleneol 70389-88-7 98%
Voleneol
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
TN3366 Ailanthoidol 156398-61-7 98%
Ailanthoidol
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
T13488 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 137089-36-2 98%
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase ...
T4484 1,7-Dihydroxy-2,3-methylenedioxyxanthone 183210-63-1 98%
1,7-Dihydroxy-2,3-methylenedioxyxanthone
1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesi...
T14500 BAY-1316957 1613264-40-6 98%
BAY-1316957
BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
T78582 15-keto-Prostaglandin E2 26441-05-4 98%
15-keto-Prostaglandin E2
15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression. ...
T78584 Prostaglandin D3 71902-47-1 98%
Prostaglandin D3
Prostaglandin D3 (PGD3) functions as an inhibitor of platelet aggregation and modulates autonomic neurotransmission in humans [1].
T78710 AMX12006 2639775-01-0 98%
AMX12006
AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].
T79432 NXT-10796 98%
NXT-10796
NXT-10796 is an orally active, intestinally restricted agonist of the EP4 receptor [1].
TN4465 Luvangetin 483-92-1 98%
Luvangetin
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN3587 Capillarisin 56365-38-9 98%
Capillarisin
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T16388 Omidenepag isopropyl 1187451-19-9 98%
Omidenepag isopropyl
Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenep...
TN5033 Skullcapflavone I 41060-16-6 98%
Skullcapflavone I
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
TN1485 Chicanine 78919-28-5 98%
Chicanine
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
Darbufelone mesylate
T10960L
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 ...
Misoprostol
T2573
Misoprostol is a useful organic compound for research related to life sciences. The catalog number is T2573 and the CAS number is 59122-46-2.
Chamigrenal
T3P2855
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO producti...
Murrangatin
TN4592
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
Voleneol
TN5248
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
Ailanthoidol
TN3366
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
T13488
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase ...
1,7-Dihydroxy-2,3-methylenedioxyxanthone
T4484
1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesi...
BAY-1316957
T14500
BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
15-keto-Prostaglandin E2
T78582
15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression. ...
Prostaglandin D3
T78584
Prostaglandin D3 (PGD3) functions as an inhibitor of platelet aggregation and modulates autonomic neurotransmission in humans [1].
AMX12006
T78710
AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].
NXT-10796
T79432
NXT-10796 is an orally active, intestinally restricted agonist of the EP4 receptor [1].
Luvangetin
TN4465
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Omidenepag isopropyl
T16388
Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenep...
Skullcapflavone I
TN5033
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
Chicanine
TN1485
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
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TargetMol