Shopping Cart

Your shopping cart is currently empty

Camonagrel

Name: Camonagrel
Brand: TargetMol
SKU: T67795
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T67795Cas No. 105920-77-2

Camonagrel is a compound with inhibitory effects on Prostaglandin E2 (PGE2).

Camonagrel

🥰Excellent

Purity: 99.25%

Catalog No. T67795Cas No. 105920-77-2

Camonagrel is a compound with inhibitory effects on Prostaglandin E2 (PGE2).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$397	In Stock	In Stock
5 mg	$970	In Stock	In Stock
10 mg	$1,290	In Stock	In Stock
25 mg	$1,950	In Stock	In Stock
50 mg	$2,620	In Stock	In Stock
100 mg	$3,530	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.25%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Camonagrel is a compound with inhibitory effects on Prostaglandin E2 (PGE2).

In vivo

In cats camonagrel (10 mg/kg i.v.) produced not only a fall in TXB2 but also a rise in 6-keto-PGF1 alpha and no change in cyclic-GMP plasma levels.[1]
camonagrel (800 mg orally) suppressed TXA2 generation by 99.5% and doubled the plasma level of 6-keto-PGF1 alpha.[1] The greatest reduction in percentage subendothelial surface occupied by platelets (mainly in the thrombi) after blood perfusion was seen after incubation with camonagrel in the range of concentrations that inhibited collagen-induced platelet aggregation. In conclusion, camonagrel reduced platelet-subendothelium interaction under flow conditions, showing this effect in a range of concentrations lower than in inhibition of platelet aggregation.[2]

Chemical Properties

Molecular Weight	272.3
Formula	C₁₅H₁₆N₂O₃
Cas No.	105920-77-2
Smiles	C(O)(=O)C1C=2C(=CC(OCCN3C=CN=C3)=CC2)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (73.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6724 mL	18.3621 mL	36.7242 mL	183.6210 mL
5 mM	0.7345 mL	3.6724 mL	7.3448 mL	36.7242 mL
10 mM	0.3672 mL	1.8362 mL	3.6724 mL	18.3621 mL
20 mM	0.1836 mL	0.9181 mL	1.8362 mL	9.1811 mL
50 mM	0.0734 mL	0.3672 mL	0.7345 mL	3.6724 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc