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Immunology/Inflammation NOS

NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).
Cat No. product name
T7206L 2-Iminobiotin hydrobromide 2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS ...
TN1650 Friedelin Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
TN1222 23-epi-26-Deoxyactein 23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. I...
TN1238 3,4-O-Isopropylidene shikimic acid 3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experiment...
TN1465 Cannabigerol Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also ...
TN1516 Cnidicin Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 mi...
TN1524 Continentalic acid Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicill...
TN1562 Dehydromiltirone Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TN1576 Diallyl disulfide Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
TN1598 Dunnianol Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
TN1599 Eburicoic acid Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme ...
TN1622 Ermanin Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent act...
TN1623 Escin IIB Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and ...
TN1834 Kobusin Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1890 Lupeol acetate Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
TN1949 Moracin C Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
TN1962 Myricetin 3-O-galactoside Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral inh...
TN2095 Pomiferin Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity....
TN2139 Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity....
TN2223 Soyacerebroside I Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
TN2232 Soyasaponin Ab Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
TN2327 Zedoarondiol Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
T10107 3-Bromo-7-nitroindazole 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messeng...
T13628 Curvularin Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iN...
TN1171 1-Dehydro-6-gingerdione 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
T11518L GW274150 GW274150 shows less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 is a selective and NADPH-dependent inhibitor of huma...
T4S0800 Demethyleneberberine Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T3408 Eleutheroside-b Syringin is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.
T2738 Dehydroandrographolide Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
T0358 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
T3491 1400W dihydrochloride 1400 W is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
T0344 Miconazole Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
T3884 Neoandrographolide Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effe...
T6570 L-NAME hydrochloride L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human...
T2876 Flavone Flavons have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.
T2S0843 Negletein 1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the acti...
T6S1256 Ruscogenin 1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
T5S0281 Tubuloside A Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes ...
T4953 Neotuberostemonine Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)...
TN1109 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
T5681 ETHYL CAFFEATE In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-r...
T5676 (Z)-SU4312 (Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
T5688 Micheliolide Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T5807 Stylopine hydrochloride Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
T7206 2-Iminobiotin 2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of...
T7191 Diphenyleneiodonium chloride Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 µM, respectively),and displays broad-spectrum bact...
T7474 7-Nitroindazole 7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
T8213 Isolinderalactone Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
TN1006 Tirucallol Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
TN1058 Pelargonidin chloride Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
TN1086 Dehydroeburicoic acid Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
T11518 GW274150 phosphate GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and r...
T15697 L-NMMA acetate L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms that including NOS1, NOS2, and NOS3 (Ki: nNOS (rat), eNOS (human), and iNOS (mouse) are a...
T7543 S-(2-aminoethyl) Isothiourea (dihydrobromide) S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0...
TN4683 Nyasol Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN4234 Hydrangenol Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
TN4286 Isodunnianol Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
TN4291 Isofuranodiene Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver dise...
TN4383 Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
TN4446 Longiferone B Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
TN4602 Myricananin A Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM.
TN4633 Neocryptotanshinone II Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
TN4648 Nepetoidin B Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TMA1570 Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4064 Flavoglaucin Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN5019 Siegeskaurolic acid Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN5021 Sikokianin C Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.
TN5164 Trans-Hinokiresinol Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
TN5186 Triptoquinone A Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory...
TN5192 Tuberosin Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner...
TN5227 (+/-)-Vestitol Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
TN5248 Voleneol 1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depende...
TN5264 Xanthoxyletin Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
T22724 Dimaprit dihydrochloride Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastr...
T19916 TRIM TRIM is an inhibitor of nNOS.
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4050 Fargesone A Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774....
T11806 L-NIO dihydrochloride L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synth...
TN3364 Agrimonolide Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
T16830 S-MTC S-MTC is a selective inhibitor of type I nitric oxide synthase.
T22419 (S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate is a potent inducible NO synthase (iNOS) inhibitor.
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 ...
T4S1616 Sanggenone D Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflamm...
TN2435 (-)-STYLOPINE (-)-STYLOPINE is a natural product from Chelidonium majus L
TN2440 Technical grade Technical grade is a natural from Magnolia sieboldii
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
TN3049 4-Methoxycinnamyl alcohol 4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.
TN3139 5alpha-Hydroxycostic acid 5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN3366 Ailanthoidol Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
TN3482 Bakkenolide B Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
TN3635 Chlojaponilactone B Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TMA1409 Cis-Mulberroside A cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
TN3694 Coniferaldehyde Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dep...
TN3744 Cyclomorusin Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of s...
TN3805 Dehydrogeijerin Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN3966 Epicatechin pentaacetate Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of V. mullaha fruit as functional food with prospective pharm...
T0947 Dexamethason acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...
2-Iminobiotin hydrobromide
T7206LCAS 76985-52-9
2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS ...
Friedelin
TN1650CAS 559-74-0
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
23-epi-26-Deoxyactein
TN1222CAS 264624-38-6
23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. I...
3,4-O-Isopropylidene shikimic acid
TN1238CAS 183075-03-8
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experiment...
Cannabigerol
TN1465CAS 25654-31-3
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also ...
Cnidicin
TN1516CAS 14348-21-1
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 mi...
Continentalic acid
TN1524CAS 19889-23-7
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicill...
Dehydromiltirone
TN1562CAS 116064-77-8
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
Diallyl disulfide
TN1576CAS 2179-57-9
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
Dunnianol
TN1598CAS 139726-29-7
Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
Eburicoic acid
TN1599CAS 560-66-7
Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme ...
Ermanin
TN1622CAS 20869-95-8
Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent act...
Escin IIB
TN1623CAS 158800-83-0
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and ...
Kobusin
TN1834CAS 36150-23-9
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...
Procyanidin B3
TN1150CAS 23567-23-9
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
Lupeol acetate
TN1890CAS 1617-68-1
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
Moracin C
TN1949CAS 69120-06-5
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
Myricetin 3-O-galactoside
TN1962CAS 15648-86-9
Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral inh...
Pomiferin
TN2095CAS 572-03-2
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
Regaloside B
TN2139CAS 114420-67-6
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity....
Regaloside B
TN2139CAS 114420-67-6
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity....
Soyacerebroside I
TN2223CAS 114297-20-0
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
Soyasaponin Ab
TN2232CAS 118194-13-1
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
Zedoarondiol
TN2327CAS 98644-24-7
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
3-Bromo-7-nitroindazole
T10107CAS 74209-34-0
3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or iNOS. It affects the intercellular messeng...
Curvularin
T13628CAS 10140-70-2
Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iN...
1-Dehydro-6-gingerdione
TN1171CAS 76060-35-0
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
Schisandrone
TN1116CAS 98619-25-1
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
GW274150
T11518LCAS 210354-22-6
GW274150 shows less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 is a selective and NADPH-dependent inhibitor of huma...
Demethyleneberberine
T4S0800CAS 25459-91-0
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
eleutheroside-b
T3408CAS 118-34-3
Syringin is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.
Dehydroandrographolide
T2738CAS 134418-28-3
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
Aminoguanidine hydrochloride
T0358CAS 1937-19-5
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
1400W dihydrochloride
T3491CAS 214358-33-5
1400 W is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
Miconazole
T0344CAS 22916-47-8
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
Neoandrographolide
T3884CAS 27215-14-1
Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effe...
L-NAME hydrochloride
T6570CAS 51298-62-5
L-NAME hydrochloride, a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human...
Flavone
T2876CAS 525-82-6
Flavons have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.
Negletein
T2S0843CAS 29550-13-8
1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the acti...
Ruscogenin
T6S1256CAS 472-11-7
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
Tubuloside A
T5S0281CAS 112516-05-9
Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes ...
Neotuberostemonine
T4953CAS 143120-46-1
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)...
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
TN1109CAS 168293-14-9
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
ETHYL CAFFEATE
T5681CAS 102-37-4
In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-r...
(Z)-SU4312
T5676CAS 90828-16-3
(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
Micheliolide
T5688CAS 68370-47-8
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
Stylopine hydrochloride
T5807CAS 96087-21-7
Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
2-Iminobiotin
T7206CAS 13395-35-2
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of...
Diphenyleneiodonium chloride
T7191CAS 4673-26-1
Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 µM, respectively),and displays broad-spectrum bact...
7-Nitroindazole
T7474CAS 2942-42-9
7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.
Isolinderalactone
T8213CAS 957-66-4
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
Tirucallol
TN1006CAS 514-46-5
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
Pelargonidin chloride
TN1058CAS 134-04-3
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Dehydroeburicoic acid
TN1086CAS 6879-05-6
Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.
GW274150 phosphate
T11518CAS 438542-15-5
GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and r...
L-NMMA acetate
T15697CAS 53308-83-1
L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms that including NOS1, NOS2, and NOS3 (Ki: nNOS (rat), eNOS (human), and iNOS (mouse) are a...
S-(2-aminoethyl) Isothiourea (dihydrobromide)
T7543CAS 56-10-0
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0...
Nyasol
TN4683CAS 96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
Hydrangenol
TN4234CAS 480-47-7
Hydrangenol is a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae), it can significantly inhibit the passive cutaneous anaphylaxis (PCA...
Isodunnianol
TN4286CAS 139726-30-0
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
Isofuranodiene
TN4291CAS 57566-47-9
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver dise...
Kazinol U
TN4383CAS 1238116-48-7
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latif...
Longiferone B
TN4446CAS 1639810-67-5
Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
Myricananin A
TN4602CAS 1079941-35-7
Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM.
Neocryptotanshinone II
TN4633CAS 27468-20-8
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block th...
Nepetoidin B
TN4648CAS 55486-06-1
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
Sappanone A
TMA1570CAS 102067-84-5
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
Flavoglaucin
TN4064CAS 523-73-9
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Siegeskaurolic acid
TN5019CAS 52645-97-3
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
Sikokianin C
TN5021CAS 159813-69-1
Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.
trans-Hinokiresinol
TN5164CAS 17676-24-3
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
Triptoquinone A
TN5186CAS 142950-86-5
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory...
Tuberosin
TN5192CAS 41347-45-9
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner...
(+/-)-Vestitol
TN5227CAS 56701-24-7
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
Voleneol
TN5248CAS 70389-88-7
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depende...
Xanthoxyletin
TN5264CAS 84-99-1
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
Dimaprit dihydrochloride
T22724CAS 23256-33-9
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastr...
TRIM
T19916CAS 25371-96-4
TRIM is an inhibitor of nNOS.
Goshonoside F5
TN4162CAS 90851-28-8
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Fargesone A
TN4050CAS 116424-69-2
Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774....
L-NIO dihydrochloride
T11806CAS 159190-44-0
L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synth...
Agrimonolide
TN3364CAS 21499-24-1
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of...
S-MTC
T16830CAS 156719-41-4
S-MTC is a selective inhibitor of type I nitric oxide synthase.
(S)-Methylisothiourea sulfate
T22419CAS 867-44-7
(S)-Methylisothiourea sulfate is a potent inducible NO synthase (iNOS) inhibitor.
Chamigrenal
T3P2855CAS 19912-84-6
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 ...
Sanggenone D
T4S1616CAS 81422-93-7
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflamm...
(-)-STYLOPINE
TN2435CAS 4312-32-7
(-)-STYLOPINE is a natural product from Chelidonium majus L
Technical grade
TN2440CAS 537-33-7
Technical grade is a natural from Magnolia sieboldii
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534CAS 22804-49-5
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
4-Methoxycinnamyl alcohol
TN3049CAS 53484-50-7
4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.
5alpha-Hydroxycostic acid
TN3139CAS 132185-83-2
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
Ailanthoidol
TN3366CAS 156398-61-7
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
Bakkenolide B
TN3482CAS 18455-98-6
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
Broussonin A
TN3539CAS 73731-87-0
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
Chlojaponilactone B
TN3635CAS 1449382-91-5
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
cis-Mulberroside A
TMA1409CAS 166734-06-1
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
Coniferaldehyde
TN3694CAS 20649-42-7
Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dep...
Cyclomorusin
TN3744CAS 62596-34-3
Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of s...
Dehydrogeijerin
TN3805CAS 16850-91-2
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
Desoxo-narchinol A
TN3839CAS 53859-06-6
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
Epicatechin pentaacetate
TN3966CAS 20194-41-6
Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of V. mullaha fruit as functional food with prospective pharm...
Dexamethason acetate
T0947CAS 1177-87-3
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...