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AhR

The aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix-period-aryl hydrocarbon receptor nuclear translocator-single-minded (bHLH-PAS) family of transcription factors, which act as biological sensors by initiating gene expression programs in response to endogenous and exogenous signals.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9112 (-)-Perillaldehyde 18031-40-8
(-)-Perillaldehyde
(-)-Perillaldehyde shows antibacterial activity.
T4928 L-Kynurenine 2922-83-0 99.91%
L-Kynurenine
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated ...
T1159 Leflunomide 75706-12-6 99.9%
Leflunomide
Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T4938 Potassium 1H-indol-3-yl sulfate 2642-37-7 99.87%
Potassium 1H-indol-3-yl sulfate
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) ha...
T5622 BAY-218 2162982-11-6 99.85%
BAY-218
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T5541 PDM11 1032508-03-4 99.77%
PDM11
PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)
T5281 Skatole 83-34-1 99.74%
Skatole
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon r...
T0343 Nimodipine 66085-59-4 99.71%
Nimodipine
Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T1831 StemRegenin 1 1227633-49-9 99.66%
StemRegenin 1
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor.
T10007 1,4-Chrysenequinone 100900-16-1 99.65%
1,4-Chrysenequinone
1,4-Chrysenequinone (Chrysene-1,4-dione) is an activator of aryl hydrocarbon receptor (AhR).
T9822 WAY-605471 378223-81-5 99.57%
WAY-605471
WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.
TN1451 Brevifolincarboxylic acid 18490-95-4 99.42%
Brevifolincarboxylic acid
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T2448 CH-223191 301326-22-7 99.01%
CH-223191
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T1046 Mexiletine hydrochloride 5370-01-4 98.44%
Mexiletine hydrochloride
Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts a...
T1960 YL-109 36341-25-0 98%
YL-109
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
T7202 ITE 448906-42-1 98%
ITE
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T10938 D-Kynurenine 13441-51-5 97.08%
D-Kynurenine
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to ...
T23151 Phortress 328087-38-3 100%
Phortress
Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor activit...
T4644 Tapinarof 79338-84-4
Tapinarof
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
T4607 CAY 10465 688348-33-6
CAY 10465
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
(-)-Perillaldehyde
T9112
(-)-Perillaldehyde shows antibacterial activity.
L-Kynurenine
T4928
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated ...
Leflunomide
T1159
Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
Potassium 1H-indol-3-yl sulfate
T4938
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) ha...
BAY-218
T5622
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
PDM11
T5541
PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)
Skatole
T5281
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon r...
Nimodipine
T0343
Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
StemRegenin 1
T1831
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor.
1,4-Chrysenequinone
T10007
1,4-Chrysenequinone (Chrysene-1,4-dione) is an activator of aryl hydrocarbon receptor (AhR).
WAY-605471
T9822
WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.
Brevifolincarboxylic acid
TN1451
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
CH-223191
T2448
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
Mexiletine hydrochloride
T1046
Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts a...
YL-109
T1960
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
ITE
T7202
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
D-Kynurenine
T10938
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to ...
Phortress
T23151
Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor activit...
Tapinarof
T4644
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
CAY 10465
T4607
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
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TargetMol