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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21493 | Cyclosporin H | Others | |
Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosp... | |||
TN1417 | Azadirachtin | Apoptosis , Antifection | |
Azadirachtin has antifungal activity, used as an insecticide. | |||
T21543 | AP 18 | TRP/TRPV Channel | |
AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete ... | |||
T7123 | AMG-47a | VEGFR , p38 MAPK , JAK , Src | |
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei... | |||
T0097 | MRT67307 | MRT67307 HCl | IκB/IKK , Autophagy |
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage... | |||
T3569 | SU5214 | SU 5214 | VEGFR , Tyrosinase |
SU5214 is a modulator of tyrosine kinase signal transduction. | |||
T3364 | Veratramine | NSC17821,NSC23880 | Sodium Channel |
Veratramine (NSC-23880)(NSC-17821; NSC-23880) is a potent signal transduction inhibitor for treating tumors. | |||
T9292 | ALE-0540 | ALE0540 | Others , Trk receptor |
ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors. | |||
T6S1844 | Tenacissoside H | Tenacissimoside C | Others |
Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade. | |||
T3406 | Kuromanin chloride | Glucocyanidin chloride,Chrysontemin,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride | NF-κB |
Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways. | |||
T40423 | L48H37 | ||
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio... | |||
T2648 | Pimecrolimus | SDZ-ASM 981,ASM 981 | Others |
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... | |||
T76780 | Onartuzumab | RG-3638,PRO-14396,MetMAb | c-Met/HGFR |
Onartuzumab (MetMAb) is a humanized anti-tyrosine kinase c-MET monovalent monoclonal antibody.Onartuzumab has antitumor activity with inhibitory effects on HGF binding, receptor phosphorylation, and signal transduction. | |||
T38617L | Biotin-TAT (47-57) acetate | Biotin-TAT (47-57) acetate(1231898-25-1 free base) | Others |
Biotin-TAT (47-57) acetate is a biotin-labeled TAT polypeptide and a transactivator of transcription. Biotin-TAT (47-57) acetate is one of the most widely used peptides in protein transduction domains. | |||
T6271 | Tipifarnib | R115777,Zarnestra,IND 58359 | Transferase |
Tipifarnib (IND 58359) is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnes... | |||
T41094 | Wnt/β-catenin agonist 2 | GSK-3 , Wnt/beta-catenin | |
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva... | |||
TN1134 | Euscaphic acid | Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor | |
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of... | |||
T2307 | Icotinib Hydrochloride | BPI-2009H | EGFR |
Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type ... | |||
T3455 | Merestinib | LY2801653 | Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase |
Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph... | |||
T76724 | Nemolizumab | CIM331 | Interleukin |
Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of interleukin-31 (IL-31) to its receptor. Nemolizumab can be u... |