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ALE-0540

Name: ALE-0540
Brand: TargetMol
SKU: T9292
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9292Cas No. 234779-34-1

Alias ALE0540

ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.

ALE-0540

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Purity: 97.62%

Catalog No. T9292Alias ALE0540Cas No. 234779-34-1

ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.

Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$56	In Stock
25 mg	$95	In Stock
50 mg	$139	In Stock
100 mg	$198	In Stock
200 mg	$272	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:97.62%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.
In vivo	Either i.p. or i.th. administration of ALE-0540 in rats produced antiallodynia in the L5/L6 ligation model of neuropathic pain. The calculated A50 values (and 95% confidence intervals) for ALE-0540 administered i.p. and i.th. were 38 (17.5–83) mg/kg and 34.6 (17.3–69.4) mg, respectively. ALE-0540 given i.th., at doses of 30 and 60 mg, also blocked tactile allodynia in the thermal sensitization model.
Synonyms	ALE0540

Chemical Properties

Molecular Weight	301.25
Formula	C₁₄H₁₁N₃O₅
Cas No.	234779-34-1
Smiles	O=C1C=2C=3C(C(=O)N1NCCO)=CC=CC3C=C(N(=O)=O)C2
Relative Density.	1.60 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (165.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3195 mL	16.5975 mL	33.1950 mL	165.9751 mL
5 mM	0.6639 mL	3.3195 mL	6.6390 mL	33.1950 mL
10 mM	0.3320 mL	1.6598 mL	3.3195 mL	16.5975 mL
20 mM	0.1660 mL	0.8299 mL	1.6598 mL	8.2988 mL
50 mM	0.0664 mL	0.3320 mL	0.6639 mL	3.3195 mL
100 mM	0.0332 mL	0.1660 mL	0.3320 mL	1.6598 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc