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Search Results for " p27 "

Targets

21

Compounds

7

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T6120 Pralatrexate Folotyn,10-Propargyl-10-deazaaminopterin Apoptosis , DHFR , Antifolate , TAM Receptor
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...
T7265 HSP27 inhibitor J2 J2 HSP
HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
T78728 SP27 PROTACs
SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].
T82566 DiaPep277
DiaPep277, a 24 amino acid peptide sourced from HSP60 positions 437-460, impedes β-cell destruction in NOD mice and modulates diabetogenic T-cell activity in animal diabetes models [1] [2].
T82683 Connexin mimetic peptide 40GAP27
Connexin mimetic peptide 40GAP27, corresponding to the GAP27 domain of the second extracellular loop of the dominant vascular connexin (Cx40), designated as 40Gap27, is a biologically active peptide utilized to study the...
T16889 SJ572403 SJ403 Others
SJ572403 is an inhibitor of disordered protein p27 with Kd of 2.2 mM for specific regions within the D2 subdomain of p27-KID. SJ572403 can be used in studies about diseases with intrinsically disordered proteins.
T4253 Skp2 Inhibitor C1 SKPin C1 Others , E1/E2/E3 Enzyme
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
T3317 SZL P1-41 Apoptosis , Others , E1/E2/E3 Enzyme
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...
T13349 WS-383 E1/E2/E3 Enzyme
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
T9229 Pim-1/2 kinase inhibitor 1 Pim
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylatio...
T13244 Ubiquitination-IN-1 Others
Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).
T68845 Americanin A
Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.
T25738 Linichlorin A Elegin
Linichlorin A is used as a p27(Kip1) ubiquitination inhibitor.
T71864 SJ572710
SJ572710 is an inhibitor of the disordered protein, p27(Kip1).
T11396 GGTI-2418 Transferase
GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors. GGTI-2418 is a highly potent, competi...
T71830 DT204
DT204 is a SCFSkp2 inhibitor which blocks Skp2 binding to Cullin-1 and Commd1, thereby synergistically enhancing BTZ-induced apoptosis and stabilization. DT204 also increases p27 levels.
T13292 VDR agonist 1 Others
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with a low IC 50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle by the up-regulation of p21 and p27, promotes apoptosis by i...
T72522 Aurora kinase-IN-1
Aurora kinase-IN-1 is a potent inhibitor of aurora kinase . Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-...
T29172 YD277 YD 277,YD-277
YD277 is a small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC c...
T69200 CGP74514A
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t...
T70962 MHY219
MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) whe...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00972 CDKN1B Protein, Human, Recombinant (His) Human E. coli
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skele...
TMPY-03842 PRNP/Prion Protein Protein, Human, Recombinant (hFc) Human HEK293
Prion protein (PRNP) gene is well known for affecting mammal transmissible spongiform encephalopathies (TSE), and is also reported to regulate phenotypic traits (e.g. growth traits) in healthy ruminants. PRNP is fundamen...
TMPJ-01268 ERP27 Protein, Human, Recombinant (His) Human Human Cells
Endoplasmic reticulum resident protein 27, also known as ER protein 27, C12orf46 and ERP27, is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family. ERP27 contains one thio...
TMPH-01457 Human herpesvirus 6B (HHV-6 variant B) (strain Z29) mRNA export factor ICP27 homolog (His & Myc) HHV-6B E. coli
TMPY-02890 ERP27 Protein, Human, Recombinant (mFc) Human HEK293
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide...
TMPK-00693 HSP27/HSPB1 Protein, Human, Recombinant (His) Human E. coli
Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-d...
TMPY-02259 FKBP25/FKBP3 Protein, Human, Recombinant (GST) Human E. coli
FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation...
Cat No. Product Name
L1300 PI3K-AKT-mTOR Compound Library

425 compounds
A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
TargetMol