nk2

Saredutant (SR 48968) is a selective neurokinin-2 (NK2) receptor antagonist that inhibits the action of neurokinin A by blocking the NK2 receptor, thereby exerting antidepressant and anxiolytic effects.

Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects.

CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.

LNK2-S is a conjugate of the toxin molecule Exatecan and a linker, utilized in the synthesis of ADC (Antibody-Drug Conjugate) molecules.

TNK2-IN-1, a TNK2 inhibitor (IC50: 224 nM), can be utilized in cancer research.

JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and IL-6 secretion via inhibition of the NF-κB MAPK pathway. It effectively mitigates symptoms associated with LPS-induced acute lung injury (ALI) and sepsis [1].

CSNK2-IN-1 is a potent and selective inhibitor of CSNK2, exhibiting IC50 values of 1.7 nM for CSNK2A1 and 0.66 nM for CSNK2A2. It demonstrates antiviral activity against β-coronaviruses, including SARS-CoV-2 and MHV. Despite its favorable solubility, metabolic stability, and low cytotoxicity, CSNK2-IN-1 experiences a rapid decline in plasma concentration in vivo, which is insufficient for pharmacological effects. This compound is suitable for research in antiviral drug development.

R 396 acetate is an NK-2 Tachykinin Receptor Antagonist.

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Ibodutant is an effective and selective tachykinin NK2 receptor antagonist (pKi: 10.1).

Fmoc-Dap(Boc)-OH, an amino acid derivative featuring an Fmoc protecting group, is utilized in the synthesis of bicyclic peptide tachykinin NK2 antagonists.

DNK 333 is a dual antagonist targeting the neurokinin NK1 NK2 receptors.

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.

Potent and selective tachykinin NK2 receptor antagonist

GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.

SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.

human tachykinin NK1 receptor antagonist

MEN 10207 is an antagonist of tachykinin.

MEN 10207 acetate is a selective antagonist for NK-2 tachykinin receptor.

R 396 (Acleu-asp-gln-trp-phe-glynh2) is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.

Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2 is a fluorescent NK2 antagonist.