nk2

Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.

GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.

Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .

Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.

Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects.

Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

MEN 10207 is an antagonist of tachykinin.

[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. This compound significantly reduces weight loss in diet-induced obesity (DIO) mouse models and improves Loperamide-induced urinary dysfunction in wild-type mice. It is applicable in the study of neurokinin receptor-mediated diseases such as obesity, insulin resistance, and type 2 diabetes.

Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

JTP10-△-R9 TFA is a selective inhibitor of the JNK2 peptide (IC50: 89 nM), demonstrating 10-fold higher selectivity for JNK2 over JNK1 and JNK3.

JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), demonstrating 10-fold selectivity for JNK2 over JNK1 and JNK3.

Scyliorhinin I is an agonist for both neurokinin-1 (NK-1) and neurokinin-2 (NK-2) receptors, exhibiting a Ki value of 0.9 nM at rat submandibular gland NK-1 receptors and 2 nM at hamster bladder NK-2 receptors. Additionally, it possesses the capability to contract the longitudinal muscle of the guinea pig ileum.

Potent and selective tachykinin NK2 receptor antagonist

MEN 10207 acetate is a selective antagonist for NK-2 tachykinin receptor.

R 396 (Acleu-asp-gln-trp-phe-glynh2) is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.

R 396 acetate is an NK-2 Tachykinin Receptor Antagonist.

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist [1].

Spantide I TFA, a selective NK1 receptor antagonist and a substance P analog, exhibits K(i) values of 230 nM for NK1 and 8150 nM for NK2 receptors, respectively. It offers a method to decrease type 1 while increasing type 2 cytokine IL-10 in the infected cornea, significantly reducing corneal perforation [1] [2] [3].

Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] [2].

GR 94800 TFA is a potent, selective antagonist of the NK 2 receptor peptide, demonstrating pK B values of 9.6 for NK 2, 6.4 for NK 1, and 6.0 for NK 3 receptors, respectively [1] [2].