Search Result

Search Results for " nlrp3 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T61392	NLRP3-IN-10	ZVN26391	NOD
	NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.		NOD
T28178	NLRP3-IN-9	INF-4E,INF 4E,INF4E	NOD
	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...		NOD
T39552	NLRP3-IN-5	NLRP3-IN-5
	NLRP3-IN-5, a compound disclosed in WO2016131098, is an inhibitor of NLRP3 inflammasome. It consists of the chemical structure N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2-l)furan-2-sulfonamide.
T61132	NLRP3-IN-11		NOD
	NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.		NOD
T39607	NLRP3 modulators 1	NLRP3 modulators 1
	NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or...
T79695	NLRP3-IN-19	NLRP3-IN-19	NOD-like Receptor (NLR)
	JT001 (NLRP3-IN-19) is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome. This action results in the suppression of cytokine release and prevention of pyroptosis. J...		NOD-like Receptor (NLR)
T60442	NLRP3/AIM2-IN-3		NOD , AIM2
	NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of N...		NOD , AIM2
T60404	NLRP3/AIM2-IN-2		AIM2
	NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.		AIM2
T62809	NLRP3-IN-7
	NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.
T81666	NLRP3-IN-22		NOD-like Receptor (NLR)
	NLRP3-IN-22 (Compound II-4) is an inhibitor of NLRP3, exhibiting a 67% inhibition rate at a concentration of 10 μM [1].		NOD-like Receptor (NLR)
T60756	NLRP3 antagonist 1
	NLRP3 antagonist 1 shows potential for the cancer research that is a potent NLRP3 antagonist. NLRP3 is involved in the body's intrinsic immunity against stress injury and pathogenic infections that is mainly expressed in...
T73015	NLRP3-IN-16		NOD-like Receptor (NLR)
	NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].		NOD-like Receptor (NLR)
T62221	NLRP3-IN-8
	NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 μM for IL-1β inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 1...
T78180	NLRP3-IN-18		NOD-like Receptor (NLR)
	NLRP3-IN-18, also known as compound 13, is a potent inhibitor of NLRP3, demonstrating an IC50 value of ≤1.0 µM [1].		NOD-like Receptor (NLR)
T73018	NLRP3-IN-13
	NLRP3-IN-13 is a selective and potent inhibitor of NLRP3 (IC 50: 2.1 μM), capable of inhibiting both NLRP3 and NLRC4 inflammasomes as well as NLRP3-mediated IL-1β production. Furthermore, NLRP3-IN-13 suppresses NLRP3 ATP...
T61826	NLRP3-IN-4
	NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis.
T73013	NLRP3-IN-14
	NLRP3-IN-14 is a potent, selective inhibitor of the NLRP3 inflammasome, displaying a dissociation constant (K D) of 5.87 μM and an IC50 of 0.131 μM for inhibiting IL-1β release. It is applicable for inflammation research...
T79733	NLRP3-IN-20		NOD-like Receptor (NLR)
	NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic propertie...		NOD-like Receptor (NLR)
T81668	NLRP3 agonist 1		NOD-like Receptor (NLR)
	NLRP3 agonist 1 (compound 23) serves as a potent, orally active agent that activates Caspase-1 enzyme, leading to the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms [1].		NOD-like Receptor (NLR)
T78168	NLRP3-IN-17		NOD-like Receptor (NLR)
	NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome, demonstrating an IC50 of 7 nM. It effectively inhibits NLRP3-dependent IL-1β secretion in mice, making it a valuable compound for...		NOD-like Receptor (NLR)
T62808	NLRP3-IN-6
	NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.
T73034	NLRP3-IN-12
	NLRP3-IN-12 is a specific inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release by targeting the NLRP3 protein, and demonstrating an IC50 of 0.45 μM. This compound is utilized in the research of inflamm...
T78894	NLRP3-IN-21		NOD-like Receptor (NLR)
	NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ...		NOD-like Receptor (NLR)
T73014	NLRP3-IN-15
	NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of...
T81665	NLRP3-IN-23		NOD-like Receptor (NLR)
	NLRP3-IN-23 (Compound 15C) is an inhibitor that significantly impedes heme-mediated activation of the NLRP3 inflammasome at a concentration of 0.1 μM [1].		NOD-like Receptor (NLR)
T81667	NLRP3 agonist 2		NOD-like Receptor (NLR)
	NLRP3 agonist 2 (compound 22) is an orally active agent that activates Caspase-1 in THP1 cells [1].		NOD-like Receptor (NLR)
T79696	JT001 sodium	NLRP3-IN-19 sodium	NOD-like Receptor (NLR)
	JT001 (NLRP3-IN-19) sodium is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome, thus curbing cytokine release and averting pyroptosis. It is utilized in research f...		NOD-like Receptor (NLR)
T60563	NLRP3/AIM2-IN-1
	NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).
T15052	Dapansutrile		NOD-like Receptor (NLR) , NOD
	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.		NOD-like Receptor (NLR) , NOD
T8828	CP 424174		IL Receptor
	CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.		IL Receptor
T9222	Emlenoflast	MCC7840	NOD-like Receptor (NLR) , NOD
	Emlenoflast (MCC7840) is a selective inhibitor of NLRP3 inflammasome.		NOD-like Receptor (NLR) , NOD
T1031	Cloxacillin sodium monohydrate	Cloxacillin Sodium,Bactopen	Antibacterial , Antibiotic
	Cloxacillin sodium monohydrate (Cloxacillin Sodium) is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity.		Antibacterial , Antibiotic
T0342	Carvedilol phosphate hemihydrate	Carvedilol phosphate,BM 14190 (phosphate hemihydrate)	VEGFR , Others , Potassium Channel , LDL , Integrin , Gap Junction Protein , NADPH , Adrenergic Receptor , Autophagy
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom...
T21233	Dihydrolipoic acid	Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid	Antioxidant
	Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr...		Antioxidant
T20731	Brilliant blue G-250	BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G	P2X Receptor
	Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) is an antagonist of the P2X7 purinergic receptor.		P2X Receptor
T13375	YQ128		IL Receptor , NOD-like Receptor (NLR) , NOD , Interleukin
	YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.		IL Receptor , NOD-like Receptor (NLR) , NOD , Interleukin
T6887	MCC950 sodium	CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950	NOD-like Receptor (NLR) , NOD
	MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2...		NOD-like Receptor (NLR) , NOD
T9572	BMS986299	Unii-VS58MO4P47	NOD
	BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.		NOD
T4164	CY-09	CY 09	NOD-like Receptor (NLR) , NOD
	CY-09 is an NLRP3 inhibitor.		NOD-like Receptor (NLR) , NOD
T61786	Selnoflast	RG 6418,RO-7486967	NOD
	Selnoflast (example 6) is a NLRP3 inhibitor[1].		NOD
T4217	INF39		NOD-like Receptor (NLR) , NOD
	INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.		NOD-like Receptor (NLR) , NOD
T79906	ADS032	BT-032	NOD
	ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity,, inhibits the activation of NLRP1 and NLRP3, inhibits Nigericin-induced IL-1β production, and can be used to study respiratory inflammation...		NOD
T25548	JC124	JC 124,JC-124	NOD
	JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.		NOD
T3701	MCC950	CP-456773	NOD
	CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and...		NOD
T27841	Lobeglitazone Sulfate	CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD
	Lobeglitazone Sulfate（CKD-501 Sulfate） is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2...		NOD
T13545	Aluminum Hydroxide		Others
	Aluminum Hydroxide is an orally active main form of aluminum used as an adjuvant. Aluminum hydroxide-based adjuvant researches including the repository effect, pro-phagocytic effect, and activation of the pro-inflammator...		Others
T11474	GSK-843	GSK'843	RIP kinase
	GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase.GSK-843 has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the ...		RIP kinase
T77675	TNKS-2-IN-1		PARP , Wnt/beta-catenin , Antibiotic
	TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity against E. coli and S. aureus.TNKS-2-IN-1 inhibits the releas...		PARP , Wnt/beta-catenin , Antibiotic
T6454	CORM-3	CORM3	Others , NF-κB , NOD-like Receptor (NLR)
	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.		Others , NF-κB , NOD-like Receptor (NLR)

Compounds

NLRP3-IN-2

T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

NLRP3-IN-5

T39552

Synonym: NLRP3-IN-5

Synonym: NLRP3 modulators 1

Target:

NLRP3-IN-19

T79695

Synonym: NLRP3-IN-19

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

NLRP3 agonist 1

T81668

Synonym:

Target: NOD-like Receptor (NLR)

NLRP3-IN-17

T78168

Synonym:

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

NLRP3 agonist 2

T81667

Synonym:

Target: NOD-like Receptor (NLR)

JT001 sodium

T79696

Synonym: NLRP3-IN-19 sodium

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR), NOD

Target: NOD-like Receptor (NLR), NOD

Cloxacillin sodium monohydrate

T1031

Synonym: Cloxacillin Sodium,Bactopen

Target: Antibacterial, Antibiotic

Carvedilol phosphate hemihydrate

T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate)

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Dihydrolipoic acid

T21233

Synonym: Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid

Target: Antioxidant

Brilliant blue G-250

T20731

Synonym: BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G

Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin

MCC950 sodium

T6887

Synonym: CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950

Target: NOD-like Receptor (NLR), NOD

BMS986299

T9572

Synonym: Unii-VS58MO4P47

Target: NOD-like Receptor (NLR), NOD

Selnoflast

T61786

Synonym: RG 6418,RO-7486967

Target: NOD-like Receptor (NLR), NOD

Synonym: JC 124,JC-124

Lobeglitazone Sulfate

T27841

Synonym: CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang

Target: PARP, Wnt/beta-catenin, Antibiotic

CORM-3

T6454

Synonym: CORM3

Target: Others, NF-κB, NOD-like Receptor (NLR)

Cat No.	Product Name	Synonyms	Targets
T20089	ATP	Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite
	ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specifi...		Endogenous Metabolite
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T2893	Muscone	3-Methylcyclopentadecanone,Methylexaltone	MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T2812	ATP disodium salt hydrate	ATP disodium,ATP disodium salt,Adenosine disodium triphosphate	Others , Endogenous Metabolite
	ATP disodium salt hydrate (Adenosine disodium triphosphate) is a nucleoside triphosphate used in cells as a coenzyme often called the "molecular unit of currency" of intracellular energy transfer.		Others , Endogenous Metabolite
T1352	ATP disodium salt	Adenosine 5'-triphosphate disodium salt,ATP,ATP disodium,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate	P2X Receptor , Endogenous Metabolite
	ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.		P2X Receptor , Endogenous Metabolite
TQ0165	Arglabin	(+)-Arglabin	NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.		NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
T6S1367	Procyanidin B2	Proanthocyanidin B2	Reactive Oxygen Species , NOD
	Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ...		Reactive Oxygen Species , NOD
T3092	Nigericin sodium salt		Potassium Channel , NOD-like Receptor (NLR) , Antibacterial , Antibiotic , NOD
	Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-...
T41245	Trimethylamine N-oxide		Reactive Oxygen Species , NOD-like Receptor (NLR) , TGF-beta/Smad
	Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging e...
T5716	4'-Methoxyresveratrol	4'-O-Methylresveratrol	advanced glycation end products
	4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced...		advanced glycation end products
T6S2315	Polyphyllin VI		Apoptosis , Antibacterial , Pyroptosis
	1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.		Apoptosis , Antibacterial , Pyroptosis
TN2063	Physalin B	NSC-287088	Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B amel...		Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
T6S1256	Ruscogenin		NOS , NF-κB , NOD-like Receptor (NLR)
	1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein ...		NOS , NF-κB , NOD-like Receptor (NLR)
T72580	Isoandrographolide
	Isoandrographolide, a compound known for its cell differentiation-inducing and hepatoprotective effects, also inhibits NLRP3 inflammasome activation and mitigates silicosis in mice.
T38838	QS-21	Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, Q...

Natural Products

ATP

T20089

Synonym: Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate

Target: Endogenous Metabolite

Synonym: 3-Methylcyclopentadecanone,Methylexaltone

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

ATP disodium salt hydrate

T2812

Synonym: ATP disodium,ATP disodium salt,Adenosine disodium triphosphate

Target: Others, Endogenous Metabolite

ATP disodium salt

T1352

Synonym: Adenosine 5'-triphosphate disodium salt,ATP,ATP disodium,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate

Target: P2X Receptor, Endogenous Metabolite

Arglabin

TQ0165

Synonym: (+)-Arglabin

Target: NOD-like Receptor (NLR), Transferase, NOD, Autophagy

Procyanidin B2

T6S1367

Synonym: Proanthocyanidin B2

Target: Reactive Oxygen Species, NOD

Nigericin sodium salt

T3092

Synonym:

Target: Potassium Channel, NOD-like Receptor (NLR), Antibacterial, Antibiotic, NOD

Trimethylamine N-oxide

T41245

Synonym:

Target: Reactive Oxygen Species, NOD-like Receptor (NLR), TGF-beta/Smad

4'-Methoxyresveratrol

T5716

Synonym: 4'-O-Methylresveratrol

Target: advanced glycation end products

Polyphyllin VI

T6S2315

Synonym:

Target: Apoptosis, Antibacterial, Pyroptosis

Physalin B

TN2063

Synonym: NSC-287088

Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD

Ruscogenin

T6S1256

Synonym:

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Synonym: Stimulon,QS-21

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01739	NLRP3 Protein, Human, Recombinant (His)	Human	E. coli
	As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polym...
TMPH-02796	NLRP3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	NLRP3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli.
TMPK-01228	MARCO Protein, Human, Recombinant (His)	Human	HEK293
	Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in...
TMPH-01723	MYD88 Protein, Human, Recombinant (His)	Human	E. coli
	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the in...
TMPH-01556	EIF2AK2 Protein, Human, Recombinant (His)	Human	Yeast
	IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to v...
TMPH-03256	CNR1 Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effe...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01035	CNR1 Protein-VLP, Human, Recombinant (His)	Human	HEK293
	G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...