NADP

NADP sodium salt (Sodium NADP) is a coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions.

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor.

Thio-NADP (S-NADP) functions as an inhibitor of nicotinic acid adenine dinucleotide phosphate (NAADP) and induces partial Ca 2+ release [1].

NADP disodium salt (Disodium NADP) is a nicotinamide adenine dinucleotide. NADP disodium salt is a key redox cofactor for electron transfer in the metabolism, serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).

6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme.

N6-Etheno-nicotinamide dinucleotide phosphate (ε-NADP+) trisodium is a structural analog of NADP(+). It acts as an inhibitor of maize malic enzyme with a Ki value of 1.01 μM.

1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.

Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) is a biochemical reagent utilized as a biomaterial or organic compound in life science research.

Isocitric Dehydrogenase (NADP), Porcine (EC 1.1.1.42) is an enzyme that catalyzes the oxidative decarboxylation of isocitric acid to produce α-ketoglutaric acid and carbon dioxide (CO2).

Aromatic Alcohol Dehydrogenase (NADP+ dependent), from Thermoanaerobium sp. (EC 1.1.1.2), is involved in the reduction of both endogenous and exogenous aldehydes and is found in nearly all tissues.

Alcohol Dehydrogenase (NADP+ dependent), Thermoanaerobium brockii (EC 1.1.1.2), is involved in the reduction of endogenous and exogenous aldehydes and is found in nearly all tissues.

L-Glutamic Dehydrogenase (NADP) from Proteus sp. (EC 1.4.1.4) catalyzes the conversion of glutamic acid to α-ketoglutaric acid.

Glutamate Dehydrogenase (NADP-dependent), Proteus sp. (EC 1.4.1.4), is an enzyme located in the mitochondria of most microorganisms and eukaryotes, responsible for converting glutamate into α-ketoglutarate.

2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundantly found in the myelin. It is utilized in coupled enzyme assays for the quantification of CNP activity. At a concentration of 5 μM, 2',3'-cNADP disodium can enhance calcium release due to calcium overload and prevent calcium-induced swelling in rat brain mitochondria.

Phosphogluconate dehydrogenase (NADP, decarboxylating) [6-Phosphogluconate dehydrogenase] is a biochemical reagent that serves as a biomaterial or organic compound utilized in life sciences research.

NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an endogenous inhibitor of ferroptosis.

NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.

NADPH tetrasodium salt (Standard) is a reference standard for research and analysis in studies involving NADPH tetrasodium salt. NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an endogenous inhibitor of ferroptosis.

NADPH (reduced nicotinamide adenine dinucleotide phosphate) is a key cellular reducing coenzyme that provides reducing power during anabolic processes such as lipid and nucleic acid synthesis, and participates in the glutathione and thioredoxin systems to maintain cellular redox homeostasis. In addition, NADPH serves as an electron donor for enzymes such as NADPH oxidase, playing a crucial role in the generation of reactive oxygen species (ROS) and immune defense processes.

Thioredoxin reductase (TrxR/NTR) is an enzyme of the pyridine nucleotide-disulfide oxidoreductase flavoprotein family. As a component of the thioredoxin system, which includes thioredoxin (Trx) and NADPH, TrxR facilitates the transfer of electrons from NADPH to Trx, acting as a reductant for proteins with disulfide bonds, and plays a role in the oxidative stress defense system.

Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.

APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.

G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) agonist that promotes glucose-6-phosphate dehydrogenase (G6PD) oligomerization to a catalytically competent form. G6PD activator AG1 reduces oxidative stress in cells and zebrafish, reduces chloroquine or diamide-induced oxidative stress in human erythrocytes, and can be used to study glucose-6-phosphate dehydrogenase deficiency.

ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM).