hl-60 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1121	Evocarpine		Apoptosis , cAMP , Anti-infection , Calcium Channel , Antibacterial
	Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
TN1684	Ginsenoside F5		Apoptosis
	Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway		Apoptosis
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T6019	Volasertib	BI 6727	Apoptosis , PLK
	Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).		Apoptosis , PLK
TJS0328	Nordalbergin	6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One	Others
	Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, can significantly induce the differentiation of HL-60 cells.		Others
T9975	GPR183	3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide	Others
	GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholes...		Others
T1882	Meisoindigo	N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III	Apoptosis
	Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).		Apoptosis
TQ0309	Glaucocalyxin B		Autophagy
	Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).		Autophagy
T67899	Topoisomerase II inhibitor 13		Topoisomerase
	Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.		Topoisomerase
T1166	Ellipticine	NSC 71795,Elliptisine	Topoisomerase
	Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6...		Topoisomerase
TN7043	Neolancerin		Others
	Neolancerin is a natural product isolated from adventitious roots of St. John’s wort (Hypericum perforatum L.).		Others
TN4375	Kamebanin		Antifection
	Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells.		Antifection
T10390	Asperphenamate		Others , Antifungal
	Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.		Others , Antifungal
TJS0487	(-)-Syringaresinol	DL-Syringaresinol,Lirioresinol b	Others
	(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and posses...		Others
T25664	Lepidiline A	Macaline A	Others
	Lepidiline A (Macaline A) is a flavonoid lignin with anti-inflammatory activity. Lepidiline A showed cytotoxic activity against HL-60 cells with IC50 of 32.3 μM. It is the active ingredient of Lepidium meyenii Walpers, a...		Others
T67922	Lepidiline C		Others
	Lepidiline C is a novel imidazoles alkaloids extracted from the root of Lepidium meenii Walpers of the brassaceae family. It has shown cytotoxic activity against HL-60 cells (IC50:27.7 μM).		Others
T5S1000	Sophoraflavanone G	Kushenol F,Vexibinol	Apoptosis
	Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.		Apoptosis
T5826	Eupalinolide A		HSP
	Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.		HSP
TN1215	(2S)-2'-Methoxykurarinone	2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt , Antifection
	(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteo...		Akt , Antifection
T14982	Clofilium tosylate		Potassium Channel
	Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.		Potassium Channel