retinoic acid

Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.

all-trans-5,6-Epoxy Retinoic Acid (Product No. T36382; CAS No. 13100-69-1) is utilized in life sciences research.

5,6-epoxy-13-cis Retinoic Acid is a metabolite of 13-cis retinoic acid.

All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is an active compound that regulates gene expression by binding to retinoic acid receptors (RAR), subsequently activating them. It plays a crucial role in the development and differentiation of the skin, offering potential anti-tumor and anti-inflammatory properties. Additionally, all-trans-3,4-Didehydro retinoic acid is under investigation for its ability to suppress various diseases, including skin disorders and certain types of cancer.

9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.

Retinoic acid-D5 is the deuterium-labeled form of Retinoic acid. Retinoic acid (T1051) is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 17 nM for PPARβ/δ. Retinoic acid, a metabolite of vitamin A, plays an important role in cell growth, differentiation and organ development. Retinoic acid (T1051) acts by activating retinoic acid receptor alpha as an inhibitor of the transcription factor Nrf2.

all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) is an active metabolite of vitamin A.

Retinoic acid-D6 is the deuterated form of Retinoic acid. Retinoic acid, a metabolite of vitamin A, plays a crucial role in cell growth, differentiation, and organ development. It is a natural agonist of the RAR nuclear receptor, with an IC50 of 14 nM for RARα/β/γ, and has a Kd value of 17 nM when binding to PPARβ/δ. Additionally, Retinoic acid (T1051) can inhibit the transcription factor Nrf2 by activating retinoic acid receptors.

Retinoic acid (Standard) is a reference standard of retinoic acid, suitable for quantitative analysis, quality control, and related research in biochemical experiments. Retinoic acid is a metabolite of vitamin A and a natural agonist of the retinoic acid receptor (RAR), activating RARα/β/γ (IC50 = 14 nM). Retinoic acid can induce cell differentiation, reduce cell proliferation, and inhibit tumorigenesis. Retinoic acid can inhibit the transcription factor Nrf2 by activating the retinoic acid receptor.

Retinoic Acid-D6 (Standard) is a reference standard of Retinoic Acid-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Retinoic acid-d6 is the deuterated form of Retinoic acid. Retinoic acid, a metabolite of vitamin A, plays a crucial role in cell growth, differentiation, and organ development. It is a natural agonist of the RAR nuclear receptor, with an IC50 of 14 nM for RARα/β/γ, and has a Kd value of 17 nM when binding to PPARβ/δ. Additionally, Retinoic acid can inhibit the transcription factor Nrf2 by activating retinoic acid receptors.

4,4-Dimethyl retinoic acid is a reagent used in biochemical reactions.

9-cis-13,14-Dihydroretinoic acid (9CDHRA) is a selective retinoid X receptor (RXR) agonist with a Kd of 90 nM. It can ameliorate memory deficits caused by impaired RXR signaling in vivo. This compound shows potential for research in the fields of neuroscience and metabolic diseases.

(-)-Talarozole [formerly R115866] is a highly effective inhibitor of retinoic acid metabolism.

Oxybenzone is a UV filter commonly used in tanning and skin protection agents. It is a derivative of benzophenone and is used as an endocrine disrupting chemical that penetrates the placental and blood-brain barriers. It impairs autophagy, alters epigenetic status and disrupts vitamin X-like receptor signaling in apoptotic neuronal cells.

Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.

Acitretin (Ro 10-1670) is a second-generation systemic retinoid used in the treatment of psoriasis.

Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs), which act as transcription factors that promote cell differentiation and apoptosis. This naturally occurring retinoic acid has potential antineoplastic activity, exhibits immunomodulatory and anti-inflammatory responses, and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.

LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)

Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.

LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).

Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.

Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.