retinoic

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.

AR7 is a retinoic acid receptor α (RARα) antagonist.

Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.

All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is an active compound that regulates gene expression by binding to retinoic acid receptors (RAR), subsequently activating them. It plays a crucial role in the development and differentiation of the skin, offering potential anti-tumor and anti-inflammatory properties. Additionally, all-trans-3,4-Didehydro retinoic acid is under investigation for its ability to suppress various diseases, including skin disorders and certain types of cancer.

9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.

all-trans-5,6-Epoxy Retinoic Acid (Product No. T36382; CAS No. 13100-69-1) is utilized in life sciences research.

5,6-epoxy-13-cis Retinoic Acid is a metabolite of 13-cis retinoic acid.

Retinoic acid-d5 (Vitamin A acid-d5) is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα β γ and a Kd of 17 nM for PPARβ δ. Retinoic acid, a metabolite of vitamin A, plays an important role in cell growth, differentiation and organ development. Retinoic acid acts by activating retinoic acid receptor alpha as an inhibitor of the transcription factor Nrf2.

Retinoic acid (Standard) is the standard substance of Retinoic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR, agonizing RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.

4,4-Dimethyl retinoic acid is a reagent used in biochemical reactions.

all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) is an active metabolite of vitamin A.

9-cis-13,14-Dihydroretinoic acid (9CDHRA) is a selective retinoid X receptor (RXR) agonist with a Kd of 90 nM. It can ameliorate memory deficits caused by impaired RXR signaling in vivo. This compound shows potential for research in the fields of neuroscience and metabolic diseases.

BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.

ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.

Namirotene (CBS 211A) is a protein biosynthesis inhibitor, a synthetic retinoic acid analog that is used in the study of corneal diseases, corneal ulcers and dry eye syndrome.

ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells.

Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and respiratory diseases.Mofarotene is a retinoic acid analog that binds to and activates retinoic acid receptors (RARs), which alters the expression of certain genes, leading to reduced cell differentiation and cell proliferation in susceptible cells.

KCL-286 is an orally available and potent retinoic acid receptor beta agonist for the amelioration of spinal cord injury (SCI).

IR820-PTX is a nanoparticle composed of IR-820 and paclitaxel that is highly permeable and tumor-targeting.IR820-PTX can be used for near-infrared fluorescence imaging and tumor diagnostics.9-cis-Retinoic Acetylcholine (RAC) is a nanoparticle that is highly permeable and tumor-targeting.

Oxybenzone is a UV filter commonly used in tanning and skin protection agents. It is a derivative of benzophenone and is used as an endocrine disrupting chemical that penetrates the placental and blood-brain barriers. It impairs autophagy, alters epigenetic status and disrupts vitamin X-like receptor signaling in apoptotic neuronal cells.

Retinyl acetate (Vitamin A acetate) is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most important.

Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).

Acitretin (Ro 10-1670) is a second-generation systemic retinoid used in the treatment of psoriasis.