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Search Result

Search Results for " p35 "

Targets

Apoptosis GSK-3 CDK

25

Compounds

28

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7426 ALSTERPAULLONE Apoptosis , GSK-3 , CDK
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
T7167 Purvalanol B NG 95 CDK , Parasite
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)
T2095 Seliciclib Roscovitine,R-roscovitine,CYC202 CDK
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).
T21588 Olomoucine ERK , CDK
Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...
T22260 Aminopurvalanol A CDK
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...
T2378 RGB-286638 free base GSK-3 , MEK , JAK , CDK
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...
T37207L Cdk5 Substrate acetate CDK
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...
T21720 GP-82996 Cdk4/6 Inhibitor IV,CINK4 CDK
GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 μM for CDK4/cyclin D1, 5.6 μM for CDK6/cyclin D1, and 25 μM for Cdk5/p35. It effectively induces apoptosis in U...
T5200 Indirubin-3'-monoxime Indirubin-3'-oxime GSK-3 , Lipoxygenase , CDK
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
T2059 Purvalanol A NG-60 Apoptosis , CDK , Autophagy
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.
T22590 AT7519 TFA AT7519 trifluoroacetate Others
AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).
T21377 Aloisine A
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GS...
T11653 Indirubin-5-sulfonate Others
Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cycli...
T37207 Cdk5 Substrate Cdk5 Substrate
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a ...
T73196 RGB-286638
RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM...
T2247 KenPaullone 9-Bromopaullone,NSC-664704 GSK-3 , CDK
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...
T1917 GSK 3 Inhibitor IX BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime Apoptosis , GSK-3 , Tyrosine Kinases , CDK
GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.
T1778 AT7519 Hydrochloride AT7519 HCl,AT 7519 hydrochloride salt Apoptosis , GSK-3 , CDK
AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
T10898 Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride Apoptosis , CDK
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...
T14779 BRD7389 SGK , FLT , Pim , CDK , S6 Kinase , DAPK
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T5533 MC180295 (rel)-MC180295 CDK
MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.
T11345L Lerociclib dihydrochloride G1T38 dihydrochloride CDK
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
TQ0068 NVP-LCQ195 AT9311,LCQ-195 CDK
NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
T10464 Atuveciclib BAY-1143572 CDK
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].
T11345 Lerociclib G1T38 CDK
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.

Compounds

ALSTERPAULLONE
T7426
Synonym:
Target: Apoptosis, GSK-3, CDK
Purvalanol B
T7167
Synonym: NG 95
Target: CDK, Parasite
Seliciclib
T2095
Synonym: Roscovitine,R-roscovitine,CYC202
Target: CDK
Olomoucine
T21588
Synonym:
Target: ERK, CDK
Aminopurvalanol A
T22260
Synonym:
Target: CDK
RGB-286638 free base
T2378
Synonym:
Target: GSK-3, MEK, JAK, CDK
Cdk5 Substrate acetate
T37207L
Synonym:
Target: CDK
GP-82996
T21720
Synonym: Cdk4/6 Inhibitor IV,CINK4
Target: CDK
Indirubin-3'-monoxime
T5200
Synonym: Indirubin-3'-oxime
Target: GSK-3, Lipoxygenase, CDK
Purvalanol A
T2059
Synonym: NG-60
Target: Apoptosis, CDK, Autophagy
AT7519 TFA
T22590
Synonym: AT7519 trifluoroacetate
Target: Others
Aloisine A
T21377
Synonym:
Target:
Indirubin-5-sulfonate
T11653
Synonym:
Target: Others
Cdk5 Substrate
T37207
Synonym: Cdk5 Substrate
Target:
RGB-286638
T73196
Synonym:
Target:
KenPaullone
T2247
Synonym: 9-Bromopaullone,NSC-664704
Target: GSK-3, CDK
GSK 3 Inhibitor IX
T1917
Synonym: BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime
Target: Apoptosis, GSK-3, Tyrosine Kinases, CDK
AT7519 Hydrochloride
T1778
Synonym: AT7519 HCl,AT 7519 hydrochloride salt
Target: Apoptosis, GSK-3, CDK
Samuraciclib hydrochloride
T10898
Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride
Target: Apoptosis, CDK
BRD7389
T14779
Synonym:
Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK
MC180295
T5533
Synonym: (rel)-MC180295
Target: CDK
Lerociclib dihydrochloride
T11345L
Synonym: G1T38 dihydrochloride
Target: CDK
NVP-LCQ195
TQ0068
Synonym: AT9311,LCQ-195
Target: CDK
Atuveciclib
T10464
Synonym: BAY-1143572
Target: CDK
Lerociclib
T11345
Synonym: G1T38
Target: CDK

Recombinant Proteins

Species：
Human (16)
Mouse (5)
EBV (2)
ZEBOV (2)
Cynomolgus (1)
MARV (1)
Rhesus (1)
Expression System：
HEK293 (15)
E. coli (9)
Baculovirus-Insect Cells (2)
CHO (1)
Yeast (1)
Tag：
His (7)
C-His (3)
hFc (3)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
N-terminal 6xHis-tagged (2)
None (2)
Tag Free (2)
Fc-Flag,Fc-His (1)
Flag,His (1)
GST (1)
Cat No. Product Name Species Expression System
TMPY-02350 IL-12 Protein, Mouse, Recombinant (His) Mouse HEK293
IL-12 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.3 kDa. Accession number: P43431&P43432
TMPY-04793 IL-35 Protein, Human, Recombinant (Flag & His) Human HEK293
IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, ...
TMPY-04863 IL-12 Protein, Human, Recombinant Human HEK293
IL-12 Protein, Human, Recombinant is expressed in HEK293. The predicted molecular weight is 57.2 kDa. Accession number: P29459-1&NP_002178.2
TMPY-00838 IL-12A Protein, Human, Recombinant (hFc) Human HEK293
Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPY-01409 IL-12A Protein, Human, Recombinant (His) Human HEK293
Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPY-06105 IL-35 Protein, Human, Recombinant (Fc-Flag & Fc-His) Human HEK293
IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, ...
TMPK-00768 ANXA1 Protein, Human, Recombinant (His) Human E. coli
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPY-02351 IL-12 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
IL-12 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 with His and hFc tag. The predicted molecular weight is 85.9 kDa. Accession number: P43431&P43432
TMPY-02349 IL-12 Protein, Mouse, Recombinant (hFc) Mouse HEK293
IL-12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 111.5 kDa. Accession number: P43431&P43432
TMPY-03879 IL-35 Protein, Human, Recombinant Human HEK293
IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, ...
TMPJ-00766 ANXA1 Protein, Human, Recombinant Human E. coli
Annexin A1 is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-infla...
TMPK-00799 ANXA1 Protein, Mouse, Recombinant (His) Mouse E. coli
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPK-01291 ANXA1 Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPY-02109 IL-12 Protein, Human, Recombinant (His) Human HEK293
IL-12 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.13 kDa. Accession number: P29459-1&NP_002178.2
TMPY-05458 IL-12 Protein, Human, Recombinant (His), Biotinylated Human HEK293
IL-12 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 with His tag. The predicted molecular weight is 60.13 kDa. Accession number: P29459.2&NP_002178.2
TMPY-00144 Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His) EBV Baculovirus-Insect Cells
Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 53.7 kDa. Accession number: A0A0B6VN60
TMPY-06322 Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated EBV HEK293
Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 55.51 kDa. Accession number: YP_401667.1
TMPH-02383 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His) MARV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
TMPH-03732 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc) ZEBOV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-03733 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc) ZEBOV HEK293
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPY-03142 IL-27 Protein, Human, Recombinant (His) Human CHO
IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPH-01399 GSTP1 Protein, Human, Recombinant (His) Human Yeast
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01398 GSTP1 Protein, Human, Recombinant (E. coli, His) Human E. coli
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-02683 GSTP1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPY-04556 CDK5 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which...
TMPY-04268 NUDC Protein, Human, Recombinant (His) Human HEK293
NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic...
TMPJ-00499 GSTP1 Protein, Human, Recombinant Human E. coli
Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in deto...
TMPY-04105 IL-12A Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
IL-12 Protein, Mouse, Recombinant (His)
TMPY-02350
Species: Mouse
Expression System: HEK293
IL-35 Protein, Human, Recombinant (Flag & His)
TMPY-04793
Species: Human
Expression System: HEK293
IL-12 Protein, Human, Recombinant
TMPY-04863
Species: Human
Expression System: HEK293
IL-12A Protein, Human, Recombinant (hFc)
TMPY-00838
Species: Human
Expression System: HEK293
IL-12A Protein, Human, Recombinant (His)
TMPY-01409
Species: Human
Expression System: HEK293
IL-35 Protein, Human, Recombinant (Fc-Flag & Fc-His)
TMPY-06105
Species: Human
Expression System: HEK293
ANXA1 Protein, Human, Recombinant (His)
TMPK-00768
Species: Human
Expression System: E. coli
IL-12 Protein, Mouse, Recombinant (His & hFc)
TMPY-02351
Species: Mouse
Expression System: HEK293
IL-12 Protein, Mouse, Recombinant (hFc)
TMPY-02349
Species: Mouse
Expression System: HEK293
IL-35 Protein, Human, Recombinant
TMPY-03879
Species: Human
Expression System: HEK293
ANXA1 Protein, Human, Recombinant
TMPJ-00766
Species: Human
Expression System: E. coli
ANXA1 Protein, Mouse, Recombinant (His)
TMPK-00799
Species: Mouse
Expression System: E. coli
ANXA1 Protein, Cynomolgus, Recombinant (His)
TMPK-01291
Species: Cynomolgus
Expression System: E. coli
IL-12 Protein, Human, Recombinant (His)
TMPY-02109
Species: Human
Expression System: HEK293
IL-12 Protein, Human, Recombinant (His), Biotinylated
TMPY-05458
Species: Human
Expression System: HEK293
Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His)
TMPY-00144
Species: EBV
Expression System: Baculovirus-Insect Cells
Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated
TMPY-06322
Species: EBV
Expression System: HEK293
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)
TMPH-02383
Species: MARV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
TMPH-03732
Species: ZEBOV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
TMPH-03733
Species: ZEBOV
Expression System: HEK293
IL-27 Protein, Human, Recombinant (His)
TMPY-03142
Species: Human
Expression System: CHO
GSTP1 Protein, Human, Recombinant (His)
TMPH-01399
Species: Human
Expression System: Yeast
GSTP1 Protein, Human, Recombinant (E. coli, His)
TMPH-01398
Species: Human
Expression System: E. coli
GSTP1 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02683
Species: Mouse
Expression System: E. coli
CDK5 Protein, Human, Recombinant (GST)
TMPY-04556
Species: Human
Expression System: Baculovirus-Insect Cells
NUDC Protein, Human, Recombinant (His)
TMPY-04268
Species: Human
Expression System: HEK293
GSTP1 Protein, Human, Recombinant
TMPJ-00499
Species: Human
Expression System: E. coli
IL-12A Protein, Rhesus, Recombinant (hFc)
TMPY-04105
Species: Rhesus
Expression System: HEK293
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