Search Result

Search Results for " p30 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TNU0864	HUP30		Potassium Channel , Calcium Channel
	HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.		Potassium Channel , Calcium Channel
T12345	CBP/p300-IN-3	P300/CBP-IN-3	Histone Acetyltransferase
	CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.		Histone Acetyltransferase
T7264	CBP/EP300-IN-1		Epigenetic Reader Domain
	CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.		Epigenetic Reader Domain
T1962	ASP3026	ASP 3026	Apoptosis , ALK
	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.		Apoptosis , ALK
T36682	USP30 inhibitor 18		DUB
	USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o...		DUB
T77560	Histone acetyltransferase p300 Inhibitor 4c		Carbonic Anhydrase , AChE
	Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.03...		Carbonic Anhydrase , AChE
T13267	USP30 inhibitor 11	USP30-IN-11	DUB
	USP30 inhibitor 11 (USP30-IN-11) is a selective USP30 inhibitor (IC50: 0.01 µΜ) that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.		DUB
T6668	SGC-CBP30		Epigenetic Reader Domain , Histone Acetyltransferase
	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).		Epigenetic Reader Domain , Histone Acetyltransferase
T63565	CBP/p300-IN-19 hydrochloride
	CBP/p300-IN-19 hydrochloride is a selective and potent inhibitor of p300/CBP HAT, capable of acting on p300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 2.2 μM), PCAF (IC50>100 μM), Myst3 (IC50>100 μM). CBP/p300-IN-19 hydrochlorid...
T10702	CBP/p300-IN-2	CBP/EP300-IN-2	Epigenetic Reader Domain , c-Myc
	CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).		Epigenetic Reader Domain , c-Myc
T72815	CBP/p300-IN-10
	CBP/p300-IN-10, a potent inhibitor targeting histone acetyltransferase enzymes EP300 and CREBBP, exhibits IC50 values of 26 nM and 39 nM, respectively. This compound shows potential for anticancer research applications.
T13191	TP3011	CH0793011	Others
	TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.		Others
T79395	CBP/p300-IN-21		Epigenetic Reader Domain
	CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits the growth of 4T1 tumors in mice [1].		Epigenetic Reader Domain
T73920	Ep300/CREBBP-IN-8
	Ep300/CREBBP-IN-8 (Example 37), a potent and orally active inhibitor of both Ep300 and CREBBP, exhibits IC50 values of 0.014 μM and 0.018 μM, respectively. This compound is utilized in cancer research [1].
T62700	CBP/p300-IN-16
	CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).
T62720	CBP/p300-IN-18
	CBP/p300-IN-18 (compound 8) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.056 μM) and LK2 H3K27 (IC50: 0.46 μM).
T63767	P300 bromodomain-IN-1
	P300 bromodomain-IN-1 is a potent inhibitor of p300 (EP300) bromodomain (IC50: 49 nM). p300 bromodomain-IN-1 blocks c-Myc expression and induces cell cycle arrest at G1/G0 phase and apoptosis in OPM-2 cells. apoptosis).
T40142	Thalidomide-NH-CBP/p300 ligand 2	Thalidomide-NH-CBP/p300 ligand 2
	Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).
T41181	IP300v
	iP300v is a negative control for iP300w
T63122	CBP/p300-IN-19
	CBP/p300-IN-19 is a potent inhibitor of p300/CBP HAT, which can act on P300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 1.4 μm), 2.2 μM), PCAF (IC50>100 μM), and Myst3 (IC50>100 μM). CBP/p300-IN-19 has anti-tumor activity.
T73923	Ep300/CREBBP-IN-4
	Ep300/CREBBP-IN-4 (Example 56), a highly effective inhibitor targeting both Ep300 and CREBBP, exhibits IC50 values of 0.024 μM and 0.064 μM, respectively. This compound is utilized in cancer research [1].
T39826	CBP/p300-IN-8	CBP/p300-IN-8
	CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains . CBP/p300-IN-8 inhibits CBP ( IC 50 =0.01-0.1 μΜ) and BRD4 ( IC 50 =1-1000 μΜ) activity.
T63110	CBP/p300-IN-15
	CBP/p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). p300-IN-15 inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50. 2.71 μM). 2.71 μM). CBP/p300-IN-15 can be used...
T62415	CBP/p300-IN-17
	CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).
T40143	PROTAC CBP/P300 Degrader-1	PROTAC CBP/P300 Degrader-1
	PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T40344	CBP/p300-IN-14	CBP/p300-IN-14
	CBP/p300-IN-14, efficiently inhibits CBP/EP300 (lysine acetyltransferase) with an IC50 value of 3.3 nM.
T73922	Ep300/CREBBP-IN-3
	Ep300/CREBBP-IN-3 (Example 61), a potent inhibitor of Ep300 and CREBBP, exhibits IC50 values of 0.056 μM and 0.095 μM, respectively. This compound is applicable in cancer research [1].
T40144	CBP/p300 ligand 2
	CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP.
T12346	CBP/p300-IN-5	P300/CBP-IN-5	Epigenetic Reader Domain
	P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).		Epigenetic Reader Domain
T73921	Ep300/CREBBP-IN-2
	Ep300/CREBBP-IN-2 (Example 73), a powerful and orally bioavailable inhibitor targeting Ep300 and CREBBP, demonstrates IC50 values of 0.052 μM and 0.148 μM, respectively. This compound is employed in cancer research [1].
T28439	PP30	PP 30,PP-30
	PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.
T23489	UBP301	UBP 301	Others
	UBP301 is a kainate receptor antagonist.		Others

Compounds

HUP30

TNU0864

Synonym:

Target: Potassium Channel, Calcium Channel

CBP/p300-IN-3

T12345

Synonym: P300/CBP-IN-3

Target: Histone Acetyltransferase

CBP/EP300-IN-1

T7264

Synonym:

Target: Epigenetic Reader Domain

ASP3026

T1962

Synonym: ASP 3026

Target: Apoptosis, ALK

Histone acetyltransferase p300 Inhibitor 4c

T77560

Synonym:

Target: Carbonic Anhydrase, AChE

Target: Epigenetic Reader Domain, Histone Acetyltransferase

CBP/p300-IN-19 hydrochloride

Synonym: CBP/EP300-IN-2

Target: Epigenetic Reader Domain, c-Myc

Target: Epigenetic Reader Domain

P300 bromodomain-IN-1

T63767

Synonym:

Target:

Thalidomide-NH-CBP/p300 ligand 2

T40142

Synonym: Thalidomide-NH-CBP/p300 ligand 2

Synonym: CBP/p300-IN-8

PROTAC CBP/P300 Degrader-1

T40143

Synonym: PROTAC CBP/P300 Degrader-1

Target:

CBP/p300-IN-14

T40344

Synonym: CBP/p300-IN-14

Synonym: P300/CBP-IN-5

Target: Epigenetic Reader Domain

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00033	ASFV (strain Ba71V) p30 Protein (His)	ASFV	E. coli
	Modifies the subcellular distribution of heterogeneous nuclear ribonucleoprotein K (HNRNPK) and may contribute to modulate HNRNPK functions related to processing and export of mRNAs during ASFV infection.
TMPY-02590	HMGB1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	HMGB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is P63158.
TMPJ-00083	NCR3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor...
TMPH-03031	P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His)	Mycoplasma pneumoniae	E. coli
	Adhesin necessary for successful cytadherence and virulence. P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular wei...
TMPY-04616	NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.3 kDa and the accession number is XP_005553604.1.
TMPY-01145	NKp30/NCR3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
TMPY-05383	NKp30/NCR3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	NKp30/NCR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is O14931-3.
TMPY-00334	NKp30/NCR3 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	NKp30/NCR3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is CAD23066.1.
TMPH-02385	Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)	MARV	E. coli
	Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary ...
TMPH-03729	Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)	ZEBOV	E. coli
	Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamer...
TMPK-00090	NKp30/NCR3 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates N...
TMPK-00091	NKp30/NCR3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates N...
TMPY-03288	USP30 Protein, Human, Recombinant (SUMO)	Human	Baculovirus Insect Cells
	Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnec...