dc1

DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.

DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 values of Ramos, Namalwa, HL60 / s

DC10SMe is a DNA alkylating agent that can be used in the synthesis of antibody-drug conjugates (ADC). The IC50 of DC10SMe for Ramos, Namalwa and HL60 / s cancer cells were 15 pM, 12 pM and 12 pM, respectively.

DDC18-8A is an amphiphilic dendritic polymer known for its potent antimicrobial and antibiofilm properties.

CDC14A/B-IN-1 (Compound 15) is an orally bioavailable inhibitor of CDC14A/B phosphatases, exhibiting inhibition constants (Ki) of 57.4 nM for CDC14A and 90.0 nM for CDC14B.

LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).

A18-Iso5-2DC18 (compound A18), a lipidoid, enhances mRNA protein expression and induces a robust immune response [1].

A2-Iso5-4DC19, a lipidoid compound, effectively facilitates the delivery of agents, including polynucleotides, to cells [1].

Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).

Iso5-2DC18, a lipid, is utilized in the synthesis of amine-containing lipids, which are instrumental in mRNA delivery, activation of the stimulator of interferon genes (STING) pathway, and demonstration of anti-tumor immunity [1].

A12-I20-2DC18, an ionizable cationic lipid, serves as an effective mRNA delivery vehicle [1].

YTHDC1-IN-1 (compound 40) serves as an effective inhibitor of YTHDC1, exhibiting a dissociation constant (Kd) of 49 nM. This compound plays a crucial role in cancer research.

Anti-Mouse VEGFR-2 Antibody (DC101-CP132) is an IgG2a, κ monoclonal antibody inhibitor derived from mice and targets mouse VEGFR-2.

Anti-Mouse CD11b Antibody (DC13) is a monoclonal inhibitory antibody targeting mouse CD11b, which can be used in immunological research.

Anti-SOSTDC1 Antibody is an antibody targeting SOSTDC1. It can be used for developmental biology, bone metabolism, and oncology research.

Anti-SOSTDC1 Antibody 2 is an antibody targeting SOSTDC1. It can be used for developmental biology, bone metabolism, and oncology research.

Anti-Mouse VEGFR-2 Antibody (DC101) is a rat-derived monoclonal antibody against mouse VEGFR2/KDR/Flk-1, serving as a mouse analogue of ramucirumab. It induces tumour cell apoptosis by blocking VEGF-VEGFR binding and inhibiting tumour angiogenesis, suitable for studying colorectal and gastric cancers.

A12-Iso5-4DC19 is an ionizable cationic lipid that enhances mRNA delivery and is utilized in research concerning RNA vaccines.

Rabacfosadine (GS-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate PMEG to tumor lymphocytes for the study of lymphoma.

TCMDC-135051 is a potent and selective PfCLK3 protein kinase inhibitor demonstrating significant antiparasiticidal activity (EC50=320 nM) while exhibiting minimal off-target toxicity. It effectively hinders the transition from trophozoite to schizont, impairs transcription, and diminishes transmission to the mosquito vector.

Permethrin (NRDC-143) is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.

ADC-13 ((5R,6S)-4-Nitrobenzyl 6-((R)-1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate) is a p-nitrobenzyl ester β-lactam derivative, functioning as an intermediate in carbapenem antibiotic synthesis.

Acid-C1-PEG5-Boc, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

TCMDC-135051 TFA is a highly selective and potent inhibitor of protein kinase PfCLK3.