| T0228 |
Methyl hesperidin |
Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
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| T1911 |
Afuresertib |
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
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| T1920 |
Capivasertib |
Capivasertib (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3).
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| T1952 |
MK-2206 dihydrochloride |
MK-2206 is a highly specific inhibitor of Akt1/2/3 (IC50: 8/12/65 nM in cell-free assays) and no effect on the activities of 250 other protein kinases.
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| T1961 |
Vistusertib |
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
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| T2176 |
2,3-Butanedione 2-Monoxime |
2,3-Butanedione 2-Monoxime is an inhibitor of skeletal and cardiac muscle contraction.
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| T2274 |
SC 79 |
SC79, a selective Akt activator, may be used to enhance Akt activity in various pathological and physiological conditions.
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| T2420 |
PHT-427 |
PHT-427 is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
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| T2482 |
AT13148 |
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
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| T2492 |
Perifosine |
Perifosine is an oral-active, alkyl-phosphocholine Akt inhibitorwith potential antineoplastic activity.
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| T2895 |
Lupeol |
Lupeol is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
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| T3001 |
Honokiol |
Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
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| T3132 |
SC66 |
SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).
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| T3346 |
AKT inhibitor VIII |
AKT inhibitor VIII is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.
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| T3399 |
Psoralidin |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive ...
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| T3467 |
Miransertib |
ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor.
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| T3560 |
Desmethylanethol trithione |
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-...
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| T3729 |
Ethyl gallate |
Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-depende...
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| T3881 |
Vaccarin |
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylatio...
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| T6065 |
Triciribine |
Triciribine is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
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| T6139 |
A-674563 |
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
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| T6251 |
PF-04691502 |
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
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| T7652 |
AM211 |
Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
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| T6285 |
GSK690693 |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
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| T6817 |
Deguelin |
Deguelin is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
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| T6849 |
Uprosertib |
Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respec...
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| T4444 |
A-674563 HCl (552325-73-2(free base)) |
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2...
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| T4S0498 |
Glaucocalyxin A |
1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreas...
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| T4S1419 |
Praeruptorin A |
1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Prae...
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| T5S0168 |
Atractylenolide II |
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK...
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| T6S0525 |
Farrerol |
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection...
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| T4489 |
AZD-26 |
AZD-26 is an allosteric AKT inhibitor (IC50: 1.04 μM).
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| T5S1632 |
8-O-Acetylshanzhiside methyl ester |
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might b...
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| T2790 |
Oridonin |
Oridonin is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with I...
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| T5574 |
Guggulsterone E&Z |
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
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| T5736 |
CYNARIN |
CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
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| T7315 |
BAY1125976 |
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
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| T7885 |
Afuresertib hydrochloride |
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
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| T4046 |
BX-517 |
BX-517 is a potent and selective inhibitor of PDK1.
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| TN1033 |
Sennidin A |
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
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| TN1034 |
Sennidin B |
Sennidin B stimulates glucose incorporation in rat adipocytes.
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| TN1269 |
3beta-Methoxy-2,3-dihydrowithaferin A |
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
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| TN1379 |
Alphitolic acid |
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytoto...
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| TN1990 |
Norathyriol |
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
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| TN1215 |
2'-Methoxykurarinone |
2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of...
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| TN1245 |
3-Deoxysappanchalcone |
3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
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| TN1458 |
Buddlejasaponin IV |
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-k...
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| TN1461 |
Butin |
Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates ox...
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| TN1549 |
Damnacanthal |
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through it...
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| TN1586 |
Dihydrorotenone |
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
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