t 100

T100-Mut is a cell-penetrating peptide that penetrates and targets the inner side of the cytoplasmic membrane by binding its N-terminus to a myristoyl group, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-related pain.

Dextran T100 (MW 100,000) is a dehydrated glucose polymer with an average molecular weight of 100,000. This compound exhibits excellent biodegradability and biocompatibility, making it suitable for applications in the food, pharmaceutical, cosmetics, and research sectors.

L-Thyroxine-13C6 (Standard) is a reference standard of L-Thyroxine-13C6 intended for quantitative analysis, quality control, and related biochemical research applications. L-Thyroxine-13C6 is the 13C labeled compound of L-Thyroxine. L-Thyroxine has a CAS number of 51-48-9. Levothyroxine is the major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Triiodothyronine-13C6 Hydrochloride (Standard) is a reference standard of Triiodothyronine-13C6 Hydrochloride intended for quantitative analysis, quality control, and related biochemical research applications. 3,3',5-Triiodothyronine-(tyrosine ring-13C6) hydrochloride is the 13C labeled compound of 3,3',5-Triiodothyronine hydrochloride.

Anti-inflammatory agent 100 (Compound (+)-4S-23) is an anti-inflammatory compound. It inhibits the MAPK and NF-κB signaling pathways by preventing the phosphorylation of IκB-α and blocking the nuclear translocation of phosphorylated p65. Anti-inflammatory agent 100 also reduces the production of NO (IC50: 0.5 μM) and the secretion of TNF-α, IL-6, and IL-1β.

Antibacterial agent 100 (Compound 7c) is effective against Staphylococcus aureus (MIC: 4 μg/mL), Candida albicans (MIC: 4 μg/mL), and Cryptococcus neoformans (MIC: 8 μg/mL).

Anticancer agent 100, a tetracaine derivative, exhibits anti-cancer activity and is applied in cancer research.

Antifungal agent 100 (compound 3i) demonstrates notable antifungal activity, exhibiting an EC 50 of 0.33 mg/L against S. sclerotiorum. It also possesses an IC 50 value of 0.63 mg/mL targeting the Succinate dehydrogenase (SDH) of the same organism [1].

A2B receptor antagonist 1 (EXAMPLE 9B) is a potent A2B adenosine receptor antagonist.

LDL-IN-3 shows anti-atherosclerotic and antioxidant activities.

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.

(±)-Tazifylline is a selective and long-acting antagonist of histamine H1 receptor. Tazifylline shows much lower affinity for H2 receptors, α- and β-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes.

(E)-Crotylbarbital (Kalypnon), an isomer of Crotylbarbital, is a barbiturate derivative that has sedative, hypnotic, and anticonvulsant effects. (E)-Crotylbarbital can be used in studies to promote mental stability and sleep.

α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action. It has more active than R enantiomer.

BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent.

JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) intended for the treatment of organ transplantation rejection, graft-versus-host reaction post-transplantation, autoimmune disorders, allergic diseases, and chronic myeloproliferative disorders.

1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antineoplastic agent.

1-Deazaadenosine, a potent Adenosine deaminase inhibitor (Ki: 0.66 μM), exhibits anti-cancer activities in vitro and holds potential as a chemotherapy agent for lymphoproliferative disorders.

1-Methyluric acid (1-Methylurate) acts on the bladder mucosa and increases the levels of insulin, triglycerides, cholesterol, and blood glucose.

Anticonvulsant agent 1 is a chemical compound with potent anticonvulsant properties.

EP1-antagonist-1 (EP1 antagonist 1) is an EP1 antagonist (pKi: 7.54; pIC50: 8.5).

COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.

COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage.