t 100

T100-Mut is a cell-penetrating peptide that penetrates and targets the inner side of the cytoplasmic membrane by binding its N-terminus to a myristoyl group, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-related pain.

Dextran T100 (MW 100,000) is a dehydrated glucose polymer with an average molecular weight of 100,000. This compound exhibits excellent biodegradability and biocompatibility, making it suitable for applications in the food, pharmaceutical, cosmetics, and research sectors.

Anti-inflammatory agent 100 (Compound (+)-4S-23) is an anti-inflammatory compound. It inhibits the MAPK and NF-κB signaling pathways by preventing the phosphorylation of IκB-α and blocking the nuclear translocation of phosphorylated p65. Anti-inflammatory agent 100 also reduces the production of NO (IC50: 0.5 μM) and the secretion of TNF-α, IL-6, and IL-1β.

Antibacterial agent 100 (Compound 7c) is effective against Staphylococcus aureus (MIC: 4 μg/mL), Candida albicans (MIC: 4 μg/mL), and Cryptococcus neoformans (MIC: 8 μg/mL).

Anticancer agent 100, a tetracaine derivative, exhibits anti-cancer activity and is applied in cancer research.

Antifungal agent 100 (compound 3i) demonstrates notable antifungal activity, exhibiting an EC 50 of 0.33 mg/L against S. sclerotiorum. It also possesses an IC 50 value of 0.63 mg/mL targeting the Succinate dehydrogenase (SDH) of the same organism [1].

ABT-100 is a potent, highly selective, and orally active inhibitor of farnesyl transferase [farnesyl-protein transferase] with broad-spectrum antitumor activity.

Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor designed to improve Duchenne muscular dystrophy.

ST-1006, a potent histamine H4 receptor agonist (pKi: 7.94), exhibits significant anti-inflammatory and anti-pruritic effects. It is also a potent inducer of basophil migration.

AT-1002 is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.

AT-1002 TFA is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.

ADT-1004 is an inhibitor of RAS. It can be used for research involving Ras-mediated diseases.

ACT-1004-1239 is an orally active, selective, and potent CXCR7 antagonist with immune-modulatory and myelin-promoting effects. It can be used to study inflammatory demyelinating diseases.

Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony-stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis.

T1001 is an antagonist of hypoxia-inducible factor-2α subunit (HIF-2α) which displaces residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization.

Avasimibe sodium is an acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor.

GAT100 is a potent and covalent negative allosteric modulator (NAM). GAT-100 behaved as a robust positive allosteric modulator of binding of orthosteric agonist CP55,940. This novel covalent probe can serve as a useful tool for characterizing CB1R allosteric ligand-binding motifs.

GL-1001 disodium tetrahydrate is an ACE2 inhibitor.

AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal preparation, AT-1001 inhibits nicotine-induced [³H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII.

Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.

Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].

BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].

Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis [1].

ALT-100 (HumanIgG4) is a human-derived antibody expressed in CHO cells, targeting NAMPT. It consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 150 kDa. For inflammation or fibrotic diseases, the isotype control for ALT-100 (HumanIgG4) is HumanIgG4(S228P) kappa, Isotype Control. For other indications, refer to HumanIgG1kappa, Isotype Control for the isotype control of ALT-100.