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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9982 | PU23 | MRP | |
PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4). | |||
T11888 | LtaS-IN-1 | Others , Antibacterial | |
LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC value... | |||
T1248 | Sulfanitran | Antibacterial , Autophagy | |
Sulfanitran is a sulfonamide antibiotic used in the poultry industry. | |||
T8596 | Ceefourin 1 | MRP | |
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor. | |||
T1631 | Sulbactam | CP45899 | Antibacterial , Antibiotic |
Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol... | |||
T12341 | P-gp inhibitor 1 | Others , P-gp | |
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells). | |||
T6685 | Sulbactam sodium | CP-45899-2 | Antibacterial , Antibiotic |
Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor. | |||
T8426 | Encequidar | HM30181,HM30181A | P-gp |
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor. | |||
T10460 | Batabulin | T138067 | Apoptosis , Microtubule Associated |
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce... | |||
T16561 | Polyoxyethylene stearate | POES | Antibacterial , P-gp |
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying. | |||
T11071 | Dofequidar fumarate | MS-209 | P-gp |
Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass... | |||
T6287 | Tariquidar | XR9576 | P-gp |
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. | |||
T4989 | Fosfomycin Tromethamine | Antibacterial , Antibiotic | |
An antibiotic produced by Streptomyces fradiae. | |||
T0351 | Risperidone | Risperidal,R 64 766 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , P-gp |
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. | |||
T3131 | Fosfomycin calcium | Phosphomycin calcium salt,Fosmicin | Antibacterial , Antibiotic |
Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. | |||
T13383 | Zamicastat | BIA 5-1058 | BCRP , Hydroxylase , P-gp |
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively). | |||
T4059 | Selamectin | UK-124114 | Chloride channel , P-gp , Parasite |
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel... | |||
T8389 | Trifluoperazine | trifluoroperazine | CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy |
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia. | |||
T11578L | Encequidar mesylate | HM30181 mesylate,HM30181A mesylate | P-gp |
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. | |||
T0100L | Atazanavir | Zrivada,Reyataz,Latazanavir,BMS-232632 | P450 , SARS-CoV , HIV Protease , P-gp |
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor. | |||
T1634 | Glibenclamide | Glyburide | Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy |
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. | |||
T20656 | Verapamil | NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil | P450 , Calcium Channel , P-gp |
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias... | |||
T16339 | Norverapamil hydrochloride | (±)-Norverapamil hydrochloride,D591 hydrochloride | Calcium Channel , P-gp , Drug Metabolite |
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. | |||
T1010 | Verapamil hydrochloride | Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride | P450 , Calcium Channel , P-gp |
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent. | |||
T0100 | Atazanavir sulfate | BMS-232632,BMS-232632 sulfate | P450 , SARS-CoV , HIV Protease , P-gp |
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. | |||
T1222 | Trifluoperazine dihydrochloride | Trifluoperazine 2HCl,SKF5019,Urinox | CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy |
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. | |||
T22330 | Fenamic acid | 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid | Chloride channel |
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc... | |||
T2657 | Elacridar | GW0918,GW120918,GF120918,GG918 | BCRP , P-gp |
Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor. | |||
T6018 | Zosuquidar trihydrochloride | Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride | P-gp |
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. | |||
T10378 | Artelinic acid | Others | |
Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum. | |||
T9944 | 3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide | MRP | |
3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1). | |||
T27954 | LY-402913 | LY 402913,LY402913 | MRP |
LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor. | |||
T22382 | NSC 31150 | Others | |
NSC 31150 is a bioactive chemical. | |||
T60009 | YS-370 | P-gp | |
YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance to paclitaxel and colchicine and exhibits stronger antitumor activity in combina... | |||
T22269 | Benzyldodecyldimethylammonium Chloride Dihydrate | Antibacterial | |
Benzyldodecyldimethylammonium chloride dihydrate can be used as an insecticide reagent. It can target drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aerugino... | |||
T5699 | SSE15206 | Apoptosis , Microtubule Associated | |
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. | |||
T15409 | GNF179 | Parasite | |
GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. | |||
T3581 | KS176 | Potassium Channel , BCRP | |
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1. | |||
T12343 | Benzquinamide | BZQ,P2647,Benzoquinamide | Adrenergic Receptor |
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzqui... | |||
T64133L | Laniquidar TFA | Laniquidar TFA(197509-46-9 Free base),R101933 | P-gp |
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavailability and can be used to modulate the multidrug resistan... | |||
T9830 | GSK2556286 | GSK286 | Antibacterial |
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul... | |||
T67727 | MCT1-IN-3 | Monocarboxylate transporter | |
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) sho... | |||
T3148 | MK-571 sodium | L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid | Leukotriene Receptor , LTR |
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... | |||
T35610 | 2,5-dimethyl Celecoxib | Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor | |
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... | |||
T24785 | S-Fcme | S Fcme,SFcme | |
S-Fcme is an activator of multidrug resistance transporter that acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding. | |||
T23868 | Ceefourin-2 | Ceefourin2,Ceefourin 2 | |
Ceefourin-2 is a highly selective multidrug resistance protein 4 inhibitor. | |||
T33683 | NITD-304 | NITD304 | |
NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates. | |||
T12714 | Reversan | CBLC4H10 | Others |
Reversan is a potent and nontoxic multidrug inhibitor of resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp). | |||
T14780 | BRD9185 | Dehydrogenase | |
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro. | |||
T27712 | KAR425 | KAR-425,KAR 425 | |
KAR425 is a bipyrrole tambjamines. KAR425 has antimalarial activity against multidrug-resistant P. yoelii in mice. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1651 | Furanodiene | Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp | |
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans. | |||
T3S0012 | Coniferyl ferulate | P-gp , GST | |
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ... | |||
T2S0223 | Isosinensetin | 6-Demethoxynobiletin | Antioxidant , HIV Protease , Antibacterial , P-gp |
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities. | |||
TN4761 | Phellamurin | P-gp | |
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini... | |||
T2S0271 | Voacamine | Voacanginine | Cannabinoid Receptor , P-gp |
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini... | |||
TJS1159 | Chrysosplenetin | Chrysosptertin B | P450 , Ferroptosis , P-gp |
Chrysosplenetin is a metabolic inhibitor of artemisinin. | |||
T3002 | Piperine | 1-Piperoylpiperidine,Bioperine | P450 , Endogenous Metabolite , P-gp , Autophagy |
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. | |||
T1589 | D-Cycloserine | RO-1-9213 | Others , Antibacterial , Antibiotic , iGluR |
D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents. | |||
T2S1200 | Sinapine | Antioxidant , P-gp , AChE | |
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities. | |||
T8262 | Fosfomycin sodium | Fosfomycin Disodium | Antibacterial , Antibiotic |
Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e... | |||
T4034 | Solamargine | Solamargin,δ-Solanigrine | Apoptosis , p38 MAPK , P-gp , STAT |
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel... | |||
T3392 | Sinapine thiocyanate | P-gp , AChE | |
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o... | |||
T2799 | (20S)-Protopanaxadiol | 20-Epiprotopanaxadiol,20(S)-APPD | Apoptosis , Reactive Oxygen Species , P-gp |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin. | |||
TN1757 | Hypophyllanthin | Potassium Channel , Calcium Channel , P-gp | |
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. | |||
TN1525 | Convallatoxin | NF-κB , P-gp , PPAR | |
Convallatoxin is a natural product | |||
T19768 | γ-Tocotrienol | gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol | Others |
γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo. | |||
T4085 | Paris saponin VII | Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII | Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy |
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation. | |||
TCS2336 | Evodine | P-gp | |
1. Evodine has antinociceptive activity. | |||
T5757 | Loganetin | Antibacterial | |
Loganetin, a non-toxic natural product, shows antibacterial activity against multidrug-resistant Gram-negative infections. | |||
T5A2455 | Arenobufagin | Others | |
Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells. | |||
T3S2019 | Lathyrol | Others | |
1.Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance. | |||
TN1342 | 8-Epidiosbulbin E acetate | Anti-infection , Antibacterial | |
8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. | |||
T6S1842 | Tenacissoside G | Tenacissimoside A | Others |
Tenacissoside G, a C21 steroid derived from the stems of Marsdenia tenacissima, can reverse multidrug resistance in cancer cells exhibiting overexpression of P-glycoprotein. | |||
T2S1120 | Ganoderenic acid B | P-gp | |
Ganoderenic acid B, a natural product derived from Ganoderma lucidum, can work by inhibiting the transport function of ABCB1 and enhancing the cytotoxicity of chemotherapy drugs against AbCB1-mediated multidrug resistant... | |||
TN4221 | Homoembelin | 2,5-dihydroxy-3-nonyl-1,4-benzoquinone | Antibacterial |
Homoembelin (2,5-dihydroxy-3-nonyl-1,4-benzoquinone) is a pigment from E. ribes and C. monocarpus that has antibacterial effects and can be used to study multidrug-resistant bacterial infections. | |||
T6S0095 | Genkwanin | 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether | Virus Protease |
1. Genkwanin (Apigenin 7-methyl ether) exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diffusion and multidrug resistance pr... | |||
T2S0265 | Robinin | NSC 9222 | TLR |
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR... | |||
TN2256 | Taccalonolide B | Microtubule Associated | |
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM. | |||
T2S0410 | Euphorbia factor L1 | Euphorbiasteroid | Apoptosis , P-gp |
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant... | |||
T4A2399 | Cinobufotalin | IL Receptor , Akt , MRP , P-gp | |
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent... | |||
TN2254 | Taccalonolide A | Apoptosis , Microtubule Associated | |
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ... | |||
T4S1419 | (±)-Praeruptorin A | Praeruptorin A,(-)-Praeruptorin A | p38 MAPK , Calcium Channel , Akt |
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... | |||
T3S2016 | Epoxylathyrol | Others | |
Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells. | |||
T13956 | Uvarigrin | Others | |
Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata. | |||
TN5114 | Taxinine | P-gp | |
Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. | |||
TN1522 | Combretol | Antifection | |
Combretol has leishmanicidal activity, it showed moderate activity (growth inhibition 87.3 and 73.0 %, respectively, at 50 μM) against a multidrug-resistant L. tropica line. Combretol also shows weakly active cytotoxic a... | |||
TN4962 | Scholaricine | Others | |
Scholaricine reverses multidrug resistance in vincristine-resistant KB cells. | |||
TN3077 | 5,5'-Dimethoxylariciresinol 4-O-glucoside | Others | |
5,5'-Dimethoxylariciresinol-4'-O-beta-D-glucoside is shown to effectively enhance chemosensitivity of resistant cells, which makes it may be a suitable candidate for potential multidrug resistance (MDR)-reversing agents. | |||
TMA0017 | Sideroxylin | Antifection | |
Sideroxylin can synergistically enhance the antimicrobial activity of the alkaloid berberine (also a constituent of H. canadensis) against Staphylococcus aureus by inhibition of the NorA multidrug resistance pump. | |||
TN1165 | (Rac)-Myrislignan | 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan | Others |
1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the min... | |||
T23610 | Acerinol | ||
Acerinol is an active ingredient from traditional Chinese medicinal herbs. It could be used as a cancer multidrug resistance reversal agent. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affec... | |||
T12518 | Polymyxin B1 | Others | |
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment. | |||
TN5113 | Taxinine B | Others | |
Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arach... | |||
T72737 | Ganoderic acid R | ||
Ganoderic acid R, exhibiting notable anticancer properties, effectively hampers tumor growth through apoptosis induction in both multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and sensitive tumor cell line (KB-A... | |||
T72735 | Coleon-U-quinone | ||
Coleon-U-quinone, a potent P-gp (P-glycoprotein) inhibitor, effectively reduces the viability of cancer cells and increases the sensitivity of multidrug-resistant cancer cells to Doxorubicin [1]. | |||
T36815 | Chevalone C | ||
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). ... | |||
T83055 | Anti-inflammatory agent 57 | ||
Compound 13, also known as Anti-inflammatory agent 57 and classified as a pyranocoumarin, is a natural product extracted from the roots of Peucedanum praeruptorum. This compound possesses both multidrug-resistance (MDR) ... | |||
T79943 | 6-C-Methylquercetin-3,4'-dimethyl ether | Antibiotic | |
6-C-Methylquercetin-3,4'-dimethyl ether is a flavonol derivative extracted from Bauhinia thonningii Schum leaves, displaying antibacterial effects on Gram-negative multidrug-resistant bacteria and methicillin-resistant S... | |||
T15097 | Deoxynivalenol | Vomitoxin,4-Deoxynivalenol | |
Deoxynivalenol (Vomitoxin) is a mycotoxin produced by Fusarium spp. of the single trichothecene family and is commonly found in contaminated food and feed.Deoxynivalenol crosses the intestinal mucosa via a cellular bypas... | |||
T35754 | Aszonapyrone A | ||
Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, ... | |||
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Cat No. | Product Name | Species | Expression System |
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TMPH-00981 | ABCB1 Protein, Human, Recombinant (His) | Human | E. coli |
ABCB1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01711 | ABCC1 Protein, Human, Recombinant (His) | Human | E. coli |
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs a... | |||
TMPY-03458 | Sorcin/SRI Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic ... | |||
TMPY-03267 | Sorcin/SRI Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic ... | |||
TMPH-03139 | MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) | Plasmodium falciparum | E. coli |
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. | |||
TMPH-02976 | YBX1 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds ... |
Cat No. | Product Name | ||
---|---|---|---|
L4520 | Anti-Bacterial Compound Library | 921 compounds | |
A unique collection of 921 antibacterial bioactive compounds, a powerful tool for antibacterial drug development; | |||
L4600 | Selected Plant-Sourced Compound Library | 3076 compounds | |
A unique collection of 3076 plant-sourced compounds that derived from 277 plant species for high throughput screening (HTS) and high content screening (HCS); |