isoquinoline

IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects.

Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide is a bioactive chemical.

Benz[g]isoquinoline-5,10-dione, an active component isolated from the ethanol extract of the aerial parts of Mitracarpus scaber, has been demonstrated through agar diffusion tests to exhibit significant in vitro inhibitory activity against AIDS-related pathogens. Additionally, it possesses notable antibacterial and antifungal properties.

MitoBloCK-6 is an effective inhibitor of Erv1 ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of

1-Hydroxyisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T64998 and the CAS number is 491-30-5.

5-Hydroxyisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T64999 and the CAS number is 2439-04-5.

2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66594 and the CAS number is 851784-82-2.

(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T66649 and the CAS number is 118864-75-8.

6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67325 and the CAS number is 2048273-58-9.

Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) acts as an inhibitor of both HIV-1 integrase (IN) and HIV-1 reverse transcriptase ribonuclease H (RT RNase H), exhibiting IC50 values of 6.32 µM and 5.9 µM, respectively.

5-Chloroisoquinoline (compound 42) acts as an inhibitor of SARM1 (Sterile alpha and toll interleukin receptor (TIR) motif containing protein 1), an enzyme involved in axonal degeneration through a ternary complex mechanism mediating various activities. This compound is utilized in research related to neurodegenerative diseases or axonal degeneration.

3,4-Dihydro-6,7-isoquinolinediol (compound 7) acts as an agonist for β2-AR, demonstrating an EC50 of 106.9 μM in CH-K1 GA1S cells. Additionally, this compound exhibits anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in lipopolysaccharide-induced RAW 264.7 murine macrophage cells.

6-Bromoisoquinoline is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

1,3-Dichloroisoquinoline is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

5-Bromoisoquinoline is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

7-Bromoisoquinoline is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

4-Bromoisoquinoline is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

8-Bromoisoquinoline is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.

Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).

1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1 2.

Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.