isoquinoline

Isoquinoline ,with CAS No. 119-65-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Isoquinoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects.

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.

Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.

M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.

Dihydropalmatine (2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline) is a natural product derived from the roots and stem barks of Berberis aristata.

Isothiazole-5-carboxylic acid (8-Isoquinoline-methaneaminedihydrochloride) is an organic compound known for its antibacterial, anticancer, and anti-inflammatory properties. It holds promise in the development of novel compounds to combat various diseases. This compound exhibits a wide range of potential pharmacological activities, aiding in the enhancement of existing inhibitory strategies.

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid ethyl ester hydrochloride ,with CAS No. 128073-50-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid ethyl ester hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-(Piperazin-1-yl)isoquinoline hydrochloride is a pharmaceutical intermediate used in the synthesis of various active compounds.

7-Amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester ,with CAS No. 171049-41-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-Amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Isoquinoline-3-carboxylic acid hydrate ,with CAS No. 203626-75-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Isoquinoline-3-carboxylic acid hydrate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Isoquinoline-4-carboxylic acid ,with CAS No. 7159-36-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Isoquinoline-4-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ethyl isoquinoline-3-carboxylate ,with CAS No. 50458-79-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Ethyl isoquinoline-3-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE, with CAS No. 799274-06-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Isoquinoline-3-carboxylic acid, with CAS No. 6624-49-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Isoquinoline-3-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide is a bioactive chemical.

Isoquinoline (Standard) is the standard substance of Isoquinoline, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments.

Benz[g]isoquinoline-5,10-dione, an active component isolated from the ethanol extract of the aerial parts of Mitracarpus scaber, has been demonstrated through agar diffusion tests to exhibit significant in vitro inhibitory activity against AIDS-related pathogens. Additionally, it possesses notable antibacterial and antifungal properties.

1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the abnormal immune responses. 2. Norisoboldine inhibits the macrophage activation and the resultant production of pro-inflammatory cytokines via down-regulating the activation of MAPKs signaling pathways rather than NF-κB.

Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities.

Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

Methyl 3-isoquinolinecarboxylate ,with CAS No. 27104-73-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl 3-isoquinolinecarboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.