iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

Cat. No.	Product name	CAS No.	Purity
T13456	(S)-Willardiine	21416-43-3	98%
T13456	(S)-Willardiine is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM).
T10781	CGP 78608 hydrochloride	1135278-54-4	98%
T10781	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant ...
T10307	AMPA receptor modulator-1	2036074-41-4	98%
T10307	AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
T34609	Selurampanel	912574-69-7	98%
T34609	Selurampanel is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study...
T13248	UK-240455	178908-09-3	98%
T13248	UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
T62839	Dalzanemdor	1629853-48-0	98%
T62839	Dalzanemdor is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
T16800	(RS)-AMPA	77521-29-0	98%
T16800	(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA ((±)-AMPA) is an effective and selective excitatory neurotransmitter L-glutamic acid agonist.
T15684	L-689560	139051-78-8	98%
T15684	L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
T23490	UBP310	902464-46-4	98%
T23490	GLUK5 kainate receptor antagonist
T3320	Dizocilpine Maleate	77086-22-7	98%
T3320	(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
T4979	Procyclidine hydrochloride	1508-76-5	98%
T4979	Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T16402	Org-26576	1026791-61-6	98%
T16402	Org-26576 is a positive allosteric modulator of the AMPA receptor.
T4096	Quinolinic acid	89-00-9	98%
T4096	Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T6504	Flupirtine maleate	75507-68-5	98%
T6504	Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
T5385	Radiprodil	496054-87-6	98%
T5385	Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
T7720	CGP 37849	127910-31-0	98%
T7720	CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents an...
T3379	Decanoic Acid	334-48-5	98%
T3379	Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
TQ0233	Traxoprodil	134234-12-1	98%
TQ0233	Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T27951	LY392098	211311-39-6	98%
T27951	LY392098 is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.
T3957	Farampator	211735-76-1	98%
T3957	Farampator (CX-691;Org24448) is a positive modulator of AMPA receptor.