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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

  • Dasolampanel
    T31208503294-13-1In house
    Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, including neuropathic pain and migraine.
    • $762
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  • L-Glutamic acid
    T2A249756-86-0
    L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
    • $42
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  • D-Cycloserine
    T158968-41-7
    D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.
    • $43
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  • L-Glutamic acid monosodium salt
    T6871142-47-2
    L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
    • $33
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  • L-Phenylalanine
    T337763-91-2
    L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
    • $42
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  • CGP 78608 hydrochloride
    T107811135278-54-4In house
    CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
    • $87
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  • DNQX disodium salt
    T84591312992-24-7
    DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
    • $133
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  • Dalzanemdor
    T628391629853-48-0In house
    Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
    • $670
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  • AMPA receptor antagonist-3
    T61813923272-18-8
    AMPA receptor antagonist-3 is an AMPA receptor antagonist.
    • $195
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  • Rapastinel acetate
    T3407L491872-39-0
    Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
    • $195
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  • AMPA receptor antagonist-2
    T61068732277-05-3
    AMPA receptor antagonist-2 is an AMPA receptor antagonist.
    • $117
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  • Dizocilpine
    T625977086-21-6
    MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
    • $57
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    TargetMol | Citations Cited
  • PEAQX tetrasodium hydrate
    T16451
    PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
    • $71
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  • UK-240455
    T13248178908-09-3In house
    UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parkinson's disease models, and is a potential candidate compound for treatment of Parkinson's disease.
    • $350
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  • AMPA receptor modulator-1
    T103072036074-41-4In house
    AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
    • $117
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  • YM90K
    T8435154164-30-4
    YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
    • $133
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  • CFM-2
    T10774178616-26-7In house
    CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
    • $54
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  • (S)-Willardiine
    T1345621416-43-3In house
    (S)-Willardiine (L-willardiine) is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM).
    • $50
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  • Selurampanel
    T34609912574-69-7In house
    Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.
    • $189
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  • LY450108
    TQ0289376594-67-1In house
    LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
    • $44
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  • glycine
    T2O272856-40-6
    glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
    • $41
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    TargetMol | Citations Cited
  • ZL006
    T172931181226-02-7
    ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
    • $32
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    TargetMol | Citations Cited
  • LSP-GR3
    T819121235945-37-5
    LSP-GR3, a novel splice modulating oligomer (SMO) consisting of chemically-modified RNA oligonucleotides, potently and specifically directs the alternative splicing of GluR to promote GluR3-flip expression across the central nervous system (CNS).
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  • QNZ46
    T23621237744-13-6
    QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
    • $47
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  • JNJ-61432059
    T156232035814-50-5
    JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1/γ-8).
    • $139
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  • BPAM344
    T91771204572-55-3
    BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
    • $39
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  • L-689560
    T15684139051-78-8
    L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an effective N-methyl-D-aspartate (NM
    • $668
    35 days
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  • Omberacetam
    T7108157115-85-0
    Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.
    • $30
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  • Coluracetam
    T7591135463-81-9
    Coluracetam (MKC-231)(MKC-231) is a Choline Uptake Enhancer.
    • $31
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  • DNQX
    T73042379-57-9
    DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
    • $51
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  • Traxoprodil
    TQ0233134234-12-1
    Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
    • $47
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  • Pregnanolone sulfate (pyridinium)
    T81409124107-39-7
    Pregnanolone sulfate pyridinium, an endogenous neurosteroid, inhibits NMDA receptors and exhibits neuroprotective properties [1].
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  • LY836
    T81899
    LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons. It has potential applications in the study of ischemic stroke [1].
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  • Org-26576
    T164021026791-61-6
    Org-26576 is a positive allosteric modulator of the AMPA receptor.
    • $41
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  • Sunifiram
    T7599314728-85-3
    Sunifiram (DM-235) is a potent nootropic agent.
    • $47
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  • Rapastinel Trifluoroacetate
    T58191435786-04-1
    Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
    • $55
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  • 1-BCP
    T757934023-62-6
    1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.
    • $47
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  • 6-Methoxy-2-naphthoic acid
    T05562471-70-7
    6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
    • $29
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  • Mephenesin
    T001559-47-2
    Mephenesin (Cresoxydiol) is a centrally acting muscle relaxant with a short duration of action.
    • $42
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  • LY-404187
    T7706211311-95-4
    LY404187 is a positive allosteric modulator of AMPA receptors
    • $34
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  • CX546
    T7580215923-54-9
    CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.
    • $37
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  • L-701324
    T1909142326-59-8
    L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
    • $56
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  • Tulrampator
    T171791038984-31-4
    Tulrampator (S-47445) is an orally bioavailable positive AMPAR with antidepressant effects.
    • $32
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  • CX516
    T1884154235-83-3
    CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
    • $32
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  • CP 465022
    T21584199655-36-2
    CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kainate-induced response with an IC50 of 25 nM in rat cortical neurons.
    • $48
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  • Sepimostat
    T8920103926-64-3
    Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM.
    • $81
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  • Procyclidine hydrochloride
    T49791508-76-5
    Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.
    • $29
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  • (RS)-AMPA
    T1680077521-29-0
    (RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.
    • $3,770
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  • SYM2206
    T16964173952-44-8
    SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated sustained currents and decreasing the survival of pancreatic cancer cells.
    • $35
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  • Flupirtine maleate
    T650475507-68-5
    Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.
    • $45
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