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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Cat. No. Product name CAS No. Purity Chemical Structure
T6618 Orphenadrine Citrate 4682-36-4 98%
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
T3407 Rapastinel 117928-94-6 98%
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T23490 UBP310 902464-46-4 98%
GLUK5 kainate receptor antagonist
T15820 Mibampator 375345-95-2 98%
Mibampator is an effective and selective AMPA receptor potentiator.
T20571 Cis-PDA 46026-75-9 98%
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
TQ0289 LY450108 376594-67-1 98%
LY450108 is a potentiator of the AMPA receptor.
T3407L Rapastinel acetate 491872-39-0 98%
Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
T61518 TAK-653 1358751-06-0 98%
TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.
T12187L Naspm trihydrochloride 1049731-36-3 98%
Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
T4096 Quinolinic acid 89-00-9
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T22542 1-Aminocyclobutanecarboxylic acid 22264-50-2
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T8435 YM90K 154164-30-4 100%
YM90K hydrochloride is an antagonist of AMPA receptor.
T8459 DNQX disodium salt 1312992-24-7 100%
DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
T10930 D-AP5 79055-68-8 100%
D-AP5 is a NMDA receptor antagonist.
T7706 LY-404187 211311-95-4 100%
LY404187 is a positive allosteric modulator of AMPA receptors
T10774 CFM-2 178616-26-7 97.16%
CFM-2 is a selective non-competitive AMPAR antagonist.
T7355 IC87201 866927-10-8 97.44%
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T4113 NBQX 118876-58-7 97.66%
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T7591 Coluracetam 135463-81-9 98%
Coluracetam(MKC-231) is a Choline Uptake Enhancer.
T7580 CX546 215923-54-9 98%
CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.
Orphenadrine Citrate
T6618
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
Rapastinel
T3407
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
UBP310
T23490
GLUK5 kainate receptor antagonist
Mibampator
T15820
Mibampator is an effective and selective AMPA receptor potentiator.
cis-PDA
T20571
cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
LY450108
TQ0289
LY450108 is a potentiator of the AMPA receptor.
Rapastinel acetate
T3407L
Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
TAK-653
T61518
TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.
Naspm trihydrochloride
T12187L
Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
Quinolinic acid
T4096
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
YM90K
T8435
YM90K hydrochloride is an antagonist of AMPA receptor.
DNQX disodium salt
T8459
DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor
D-AP5
T10930
D-AP5 is a NMDA receptor antagonist.
LY-404187
T7706
LY404187 is a positive allosteric modulator of AMPA receptors
CFM-2
T10774
CFM-2 is a selective non-competitive AMPAR antagonist.
IC87201
T7355
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
NBQX
T4113
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
Coluracetam
T7591
Coluracetam(MKC-231) is a Choline Uptake Enhancer.
CX546
T7580
CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.
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