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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Cat. No. Product name CAS No. Purity Chemical Structure
T13456 (S)-Willardiine 21416-43-3 98%
(S)-Willardiine is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM).
T10781 CGP 78608 hydrochloride 1135278-54-4 98%
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant ...
T10307 AMPA receptor modulator-1 2036074-41-4 98%
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
T34609 Selurampanel 912574-69-7 98%
Selurampanel is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study...
T13248 UK-240455 178908-09-3 98%
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
T62839 Dalzanemdor 1629853-48-0 98%
Dalzanemdor is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
T16800 (RS)-AMPA 77521-29-0 98%
(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA ((±)-AMPA) is an effective and selective excitatory neurotransmitter L-glutamic acid agonist.
T15684 L-689560 139051-78-8 98%
L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
T23490 UBP310 902464-46-4 98%
GLUK5 kainate receptor antagonist
T3320 Dizocilpine Maleate 77086-22-7 98%
(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
T4979 Procyclidine hydrochloride 1508-76-5 98%
Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T16402 Org-26576 1026791-61-6 98%
Org-26576 is a positive allosteric modulator of the AMPA receptor.
T4096 Quinolinic acid 89-00-9 98%
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T6504 Flupirtine maleate 75507-68-5 98%
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
T5385 Radiprodil 496054-87-6 98%
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
T7720 CGP 37849 127910-31-0 98%
CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents an...
T3379 Decanoic Acid 334-48-5 98%
Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
TQ0233 Traxoprodil 134234-12-1 98%
Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T27951 LY392098 211311-39-6 98%
LY392098 is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.
T3957 Farampator 211735-76-1 98%
Farampator (CX-691;Org24448) is a positive modulator of AMPA receptor.
(S)-Willardiine
T13456
(S)-Willardiine is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM).
CGP 78608 hydrochloride
T10781
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant ...
AMPA receptor modulator-1
T10307
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
Selurampanel
T34609
Selurampanel is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study...
UK-240455
T13248
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
Dalzanemdor
T62839
Dalzanemdor is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
(RS)-AMPA
T16800
(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA ((±)-AMPA) is an effective and selective excitatory neurotransmitter L-glutamic acid agonist.
L-689560
T15684
L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in ...
UBP310
T23490
GLUK5 kainate receptor antagonist
Dizocilpine Maleate
T3320
(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has b...
Procyclidine hydrochloride
T4979
Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
Org-26576
T16402
Org-26576 is a positive allosteric modulator of the AMPA receptor.
Quinolinic acid
T4096
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
Flupirtine maleate
T6504
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal pot...
Radiprodil
T5385
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic ...
CGP 37849
T7720
CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents an...
Decanoic Acid
T3379
Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
Traxoprodil
TQ0233
Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
LY392098
T27951
LY392098 is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.
Farampator
T3957
Farampator (CX-691;Org24448) is a positive modulator of AMPA receptor.
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