imidazole

Imidazole is a planar 5-membered ring and a highly polar compound. It has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules.

Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).

Detomidine hydrochloride (MPV-253 AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.

Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.

Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.

1H-Imidazole-4-carboxylic acid ,with CAS No. 1072-84-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-Imidazole-4-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1H-imidazole, 1-methyl-2-[(phenylmethyl)thio]- ,with CAS No. 63348-55-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-imidazole, 1-methyl-2-[(phenylmethyl)thio]- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1H-imidazole, 4,5-dihydro-2-(methylthio)-1-(phenylmethyl)-, hydriodide (1:1) ,with CAS No. 550347-66-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-imidazole, 4,5-dihydro-2-(methylthio)-1-(phenylmethyl)-, hydriodide (1:1) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-[(3-Chlorobenzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride ,with CAS No. 258347-64-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-[(3-Chlorobenzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-[(2-Chlorobenzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride ,with CAS No. 673434-79-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-[(2-Chlorobenzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(Methylthio)-4,5-dihydro-1H-imidazole hydrobromide ,with CAS No. 40241-78-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(Methylthio)-4,5-dihydro-1H-imidazole hydrobromide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole ,with CAS No. 1351478-35-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker used for the synthesis of PROTAC IRAK4 degrader-1[1].

Imidazole-D4 is an isotope-labeled variant of imidazole, which is a heterocyclic aromatic compound. Imidazole (T5202) molecules serve as inhibitors for acetylcholinesterase (AChEI) and xanthine oxidase (XO) and have been utilized as corrosion inhibitors. They display a range of biological activities, including antifungal, antitubercular, anti-inflammatory, antioxidant, and analgesic properties. Imidazole (T5202) inhibits platelet microsomes from converting endoperoxides (PGG2 and PGH2) into thromboxane A2. Additionally, imidazole derivatives show inhibitory effects on the SARS-CoV-2 3CLpro enzyme, offering potential for research in Alzheimer’s disease, gout, COVID-19, and thrombotic disorders.

Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.

1-((4-Chlorophenyl)diphenylmethyl)-1H-imidazole is a useful organic compound for research related to life sciences and the catalog number is T64547.

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole hydrate is a useful organic compound for research related to life sciences and the catalog number is T64826.

Imidazole hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65251 and the CAS number is 1467-16-9.

Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65341 and the CAS number is 144689-94-1.

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.

Ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65738 and the CAS number is 139481-41-7.

1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole is a useful organic compound for research related to life sciences. The catalog number is T65771 and the CAS number is 152628-02-9.

4-Bromo-1H-imidazole, with catalog number T65957 and CAS number 2302-25-2, is a valuable organic compound for life sciences research.