imidazole

Imidazole is a planar 5-membered ring and a highly polar compound. It has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules.

AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker used for the synthesis of PROTAC IRAK4 degrader-1[1].

Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.

Imidazole mustard is an inhibitor of purine nucleoside synthesis.

Imidazole-5-propionic acid (Imidazolylpropionic acid) is a product of histidine metabolism and may involve oxidation or transamination. Imidazole-5-propionic acid is potent inhibitors of G. candidum histidinol dehydrogenase, showing IC50 values as low as 3.17 microM.

1H-Imidazole-2-carbaldehyde is an imidazole containing an aldehyde group, widely used in biochemical experiments and drug synthesis research.

1-Trityl-1H-imidazole-4-carbaldehyde is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

4-Iodo-1H-imidazole is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Imidazole ketone erastin (IKE) is an ferroptosis inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has antitumor activity and induces glutathione depletion and lipid peroxidation.

4-Phenylimidazole(4-Phl) is used to study cytochrome P450 interaction with protein-ligand as a heme ligand in the crystallization process of recombinant human tryptophan 2, 3-dioxygenase.

5-Amino-3H-imidazole-4-Carboxamide (AICA) is an imidazole derivative and a metabolite of the antineoplastic agents BIC and DIC. It serves as a condensation agent in the preparation of nucleosides and nucleotides, and when compounded with orotic acid, it is used to treat liver diseases.

5,6-Dimethyl-1H-benzo[d]imidazole (5,6-Dimethylbenzimidazole) is an intermediate in Riboflavin metabolism and is the penultimate step in the synthesis of alpha-Ribazole. It is converted from Riboflavin and subsequently transformed into N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole by the enzyme nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21).

2,4,5-Tribromoimidazole (2,4,5-Tribromo-1H-imidazole) is a marine derived natural products found in Hexaplex trunculus.

5-Aminoimidazole ribonucleotide (AIR) serves as an intermediate in purine biosynthesis, undergoing enzymatic modifications to form inosine monophosphate (IMP), which is subsequently converted into the purine bases adenine (A) and guanine (G) [1].

Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).

Detomidine hydrochloride (MPV-253 AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.

Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.

Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.

cis-Urocanic acid ((E)-Urocanic acid) is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.

Ensulizole is a sulfonated ultraviolet absorber that strongly absorbs UVB and some UVA, and under UV or sunlight exposure, it produces reactive oxygen species that can damage DNA.

CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.

KUN56321 (3H-Naphth[1,2-d]imidazole, 2-(4-bromophenyl)-3-phenyl-) is a luminescent agent. The application of KUN56321 comprises: coating the film of KUN56321 onto hole transport layer or electron transport layer of ITO glass by vacuum evapn.coating the hole transport layer or electron transport layer onto the film by evapn., prepg. metal electrode by evapn. KUN56321 showed the capability to improve light emitting efficiency and reducing drive voltage in org. light- emitting device and display device.