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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

Search Result

Search Results for "artery"

Libraries

Anti-Cardiovascular Disease Compound Library Saccharide and Glycoside Natural Product Library
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Compounds

Cat No. Product Name
T9023 Atuliflapon AZD5718 FLAP
Atuliflapon 是可口服的FLAP (5 -脂氧合酶激活蛋白)的抑制剂，IC50值为 2 nM，可用于冠状动脉疾病的研究。
T6792 BQ-123 BQ123 Endothelin Receptor
BQ123 是高效的内皮素 A(ETA)受体选择性拮抗剂，其IC50=7.3 nM，Ki=25 nM。它能够降低高血压大鼠血压，抑制内皮素-1 介导的人肺动脉平滑肌细胞增殖。
TN6715 7-Ketocholesterol Others
7-Ketocholesterol 是胆固醇的代谢物。
T4330 CaCCinh-A01 Chloride channel
CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂，IC50值分别为 10 和 2.1 μM。
T19659 Annaosanchun YC-6,YC6,YC 6,雄甾-3,5,6三醇 Others , AMPK
Annaosanchun 有可能用于治疗急性缺血性中风（AIS）。
T1476 Pramipexole 普拉克索,SND 919 Dopamine Receptor
Pramipexole 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂，对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。
T24873 TGX-115 TGX 115 PI3K
TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM），是一种调节血小板粘附过程的酶，可抑制磷酸肌苷（PI）3-激酶，可用来治疗...
T1986 Atopaxar ER-172594-00,E5555 Protease-activated Receptor
Atopaxar 是一种高效、可口服的，选择性的，可逆的凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。它是一种抗血小板剂，能干扰血小板信号，可用于动脉粥样硬化血栓性疾病的研究。
T6033 Zotarolimus ABT-578,A 179578,咗他莫司,佐他莫司 mTOR
Zotarolimus 是一种免疫抑制剂，是雷帕霉素的衍生物，具有抗增殖活性。它被专门开发作为局部输送支架用于预防冠状动脉再狭窄。
T2480 Apabetalone RVX-208,RVX000222,阿帕他隆 Epigenetic Reader Domain , HIV Protease
Apabetalone 是一种 BET 溴结构域抑制剂，用于研究治疗糖尿病、动脉粥样硬化和冠状动脉疾病。
T27627 Iroxanadine BRX-235,BRX-005 p38 MAPK
Iroxanadine 是一种新型小分子MAPK p38 抑制剂，诱导p38 SAPK 的磷酸化，在用去氧肾上腺素预先收缩的豚鼠肺动脉制剂中诱导浓度依赖性松弛，可用于治疗动脉粥样硬化、糖尿病血管病，微血管心绞痛和外周动脉疾病等血管疾病。
T23557 Talibegron hydrochloride ZD2079 hydrochloride Adrenergic Receptor
Talibegron hydrochloride 是一种β3肾上腺素能受体激动剂，对苯肾上腺素预收缩大鼠肠系膜动脉的 pD2为3.72。松弛大鼠肠系膜动脉和离体主动脉。在体内抑制瘦小鼠 ob 基因表达和循环瘦素水平。
T4179 Probucol disuccinate LDL
Probucol disucinate 是一种 Probucol 的衍生物。其中 Probucol 是脂质调节的化合物，它能降低 LDL-cholesterol 水平。
T4287 Succinobucol AGI-1067,Probucol monosuccinate Antioxidant , Reactive Oxygen Species
Succinobucol 是酚类抗氧化剂，具有抗炎、抗血小板聚集活性。
S00015 Tea polyphenol Autophagy , Apoptosis , Others
Tea polyphenol 也称为绿茶提取物，是茶中天然存在的酚类化合物，具有抗癌、抗氧化、抑制细胞增殖、诱导细胞凋亡、延缓细胞周期和调节致癌物代谢等生物活性。
T2803 Monocrotaline 野百合碱,Crotaline TGF-beta/Smad
Monocrotaline 是一种吡咯里西啶生物碱，从猪屎豆植物的种子中提取得到，可诱导啮齿动物产生肺动脉高血压。
T8687 Diaminohydroxypropanetetraacetic acid Others
diaminohydroxypropanetetraacetic acid 已被研究用于治疗血管疾病、冠状动脉疾病、心肌缺血、冠状动脉再狭窄和冠状动脉疾病等。
T61028 Mitiperstat AZD4831 Glutathione Peroxidase
Mitiperstat 是一种强效的骨髓过氧化物酶（MPO）抑制剂。Mitiperstat 对预防如心力衰竭和冠状动脉疾病类的心血管疾病有很好的效果。
T23146 PHA 568487 free base PHA 568487 AChR
PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂，可用于减缓神经炎症。
T4S1422 Praeruptorin E 白花前胡素E,白花前胡素 E Calcium Channel , Others
Praeruptorin E 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.2。
Atuliflapon
T9023
synonym: AZD5718
Target:
BQ-123
T6792
synonym: BQ123
Target:
7-Ketocholesterol
TN6715
synonym:
Target:
CaCCinh-A01
T4330
synonym:
Target:
Annaosanchun
T19659
synonym: YC-6,YC6,YC 6,雄甾-3,5,6三醇
Target:
Pramipexole
T1476
synonym: 普拉克索,SND 919
Target:
TGX-115
T24873
synonym: TGX 115
Target:
Atopaxar
T1986
synonym: ER-172594-00,E5555
Target:
Zotarolimus
T6033
synonym: ABT-578,A 179578,咗他莫司,佐他莫司
Target:
Apabetalone
T2480
synonym: RVX-208,RVX000222,阿帕他隆
Target:
Iroxanadine
T27627
synonym: BRX-235,BRX-005
Target:
Talibegron hydrochloride
T23557
synonym: ZD2079 hydrochloride
Target:
Probucol disuccinate
T4179
synonym:
Target:
Succinobucol
T4287
synonym: AGI-1067,Probucol monosuccinate
Target:
Tea polyphenol
S00015
synonym:
Target:
Monocrotaline
T2803
synonym: 野百合碱,Crotaline
Target:
diaminohydroxypropanetetraacetic acid
T8687
synonym:
Target:
Mitiperstat
T61028
synonym: AZD4831
Target:
PHA 568487 free base
T23146
synonym: PHA 568487
Target:
Praeruptorin E
T4S1422
synonym: 白花前胡素E,白花前胡素 E
Target:
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