β-lactam

L-lysine lactam is a building block.1,2It has been used in the synthesis of lysine sulfonamide HIV protease inhibitors, as well as bengamide derivatives within vitroanticancer activity.

D-Ornithine lactam is a building block. It has been used in the synthesis of hepatitis C virus non-structural protein 5B inhibitors, as well as αVβ3 integrin receptor antagonists.

L-Ornithine lactam is a synthetic intermediate. It has been used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides.

GW779439X is a pyrazolopyridazine compound that inhibits the S. aureus kinase Stk1 and Aurora kinase A (AURKA). It restores the efficacy of β-lactam antibiotics against methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) S. aureus, often re-sensitizing resistant strains. This antibacterial potentiation is achieved through the induction of apoptosis via caspase-3/7 pathway activation.

Methicillin sodium salt is the sodium salt form of methicillin, a semisynthetic beta-lactam penicillin antibiotic with beta-lactamase resistant activity.

Ceftibuten dihydrate (Sch-39720 dihydrate) is the dihydrate form of ceftibuten, and is a third-generation cephalosporin with antibacterial activity.

MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.

Clavulanate lithium (Clavulanic acid lithium) is an inhibitor of β-lactamase.

ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.

Cefoselis Sulfate is a widely used beta-lactam antibiotic.

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.

D-Lysine lactam is a chiral compound suitable for biochemical experiments and drug synthesis research.

Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1It is a degradation product formed by exposure to thermal or oxidative stress. 1.Baertschi, S.W., Brunner, H., Bunnell, C.A., et al.Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulationsJ. Pharm. Sci.97(2)883-892(2008)

N-Methyl lactam (Compound 3b), an analogue of peramiue, exhibits feeding-deterrent activity in adult weevils [1].

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

β-Lactamase-IN-9 (compound 2) is an inhibitor of β-lactamase, capable of restoring the sensitivity of pathogens to β-lactam antibiotics.

Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor that can potentially restore the activity of current β-lactam antibiotics and provide an orthogonal strategy for discovering new antibiotics. It exhibits high activity against VIM-1 and NDM-1, with IC50 values of 0.6 and 1.0 μM, respectively, but does not inhibit IMP-7 [1].

β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) is a β-Lactamase inhibitor and targets the infection of Neisseria gonorrhoeae.

Metallo-β-lactamase-IN-16 (compound 18), a sulfone-containing metallo-β-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-β-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.

Metallo-β-lactamase-IN-12 is a dual inhibitor targeting Metallo-β-lactamase [MβLs (NDM-1, IMP-1)] and Serine β-lactamase [SβLs (OXA-48, KPC-2)], displaying IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM respectively. Metallo-β-lactamase-IN-12 also exhibits antibacterial activity.

β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.

β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.

β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.

β-Lactamase-IN-6 is a β-lactamase inhibitor with high antibacterial activity.