Cart
Neuroscience NMDAR

NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Cat No. product name
T9133 Caroverine HCL Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent tha...
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T4225 Dextrorphan tartrate Dextrorphan D-tartrate is a noncompetitive NMDA glutamate receptor antagonist.
T3320 Dizocilpine Maleate (+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug ha...
T6259 Dizocilpine MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
T6504 Flupirtine maleate Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal po...
T6608 NMDA N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
T0015 Mephenesin Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T0015 Mephenesin Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T3486 3-MATIDA 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0802 Procaine hydrochloride
T1324 Phosphoserine Phosphoserine is the phosphoric acid ester of serine.
T6352 (-)-MK 801 Maleate MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T1308 Orphenadrine hydrochloride Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T1946 Felbamate Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0556 6-Methoxy-2-naphthoic acid 6-Methoxy-2-naphthoic acid is an modulator of NMDAR.
T1186 Ifenprodil Tartrate Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T0349 Riluzole Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T1909 L701324 L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T1897 MDL 29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T2362 QNZ46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T1751 Eliprodil Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has ...
T4171 PEAQX PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 ...
T4096 Quinolinic acid Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T22733 DL-AP5 NMDA antagonist
T8394 (R)-Serine (R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
T8626 4-oxo-1,4-dihydroquinoline-2-carboxylic acid 4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
T17293 ZL006 ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T16473 Perzinfotel Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with ne...
T16332 NKH477 NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 s...
T10930 D-AP5 D-AP5 is a NMDA receptor antagonist.
T8450 TCN213 TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T8351 UBP551 UBP551 is a potent and selective NMDA receptors modulator.
TN1420 Bacopaside I Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/P...
T7870 TCN-201 TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T4979 Procyclidine hydrochloride Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T7867 Flutriafol Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
T7778 Glypromate Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
TQ0279 Ibotenic acid Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
TQ0233 Traxoprodil Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
TQ0027 Transcrocetinate disodium Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T5819 Rapastinel Trifluoroacetate Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
T5080 Spermidine hydrochloride Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
T4752 1-Aminocyclopropanecarboxylic acid 1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from s...
T4885 D-Aspartic acid D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA ...
T5385 Radiprodil Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic...
T6975 Sarcosine Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Caroverine HCL
T9133CAS 55750-05-5
Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent tha...
Memantine hydrochloride
T1443CAS 41100-52-1
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Dextrorphan tartrate
T4225CAS 143-98-6
Dextrorphan D-tartrate is a noncompetitive NMDA glutamate receptor antagonist.
Dizocilpine Maleate
T3320CAS 77086-22-7
(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug ha...
Dizocilpine
T6259CAS 77086-21-6
MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
Flupirtine maleate
T6504CAS 75507-68-5
Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal po...
NMDA
T6608CAS 6384-92-5
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
Mephenesin
T0015CAS 59-47-2
Mephenesin is a centrally acting muscle relaxant with a short duration of action.
Mephenesin
T0015CAS 59-47-2
Mephenesin is a centrally acting muscle relaxant with a short duration of action.
3-MATIDA
T3486CAS 518357-51-2
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Procaine hydrochloride
T0802CAS 51-05-8
Phosphoserine
T1324CAS 407-41-0
Phosphoserine is the phosphoric acid ester of serine.
(-)-MK 801 Maleate
T6352CAS 121917-57-5
MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Orphenadrine hydrochloride
T1308CAS 341-69-5
Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Felbamate
T1946CAS 25451-15-4
Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
6-Methoxy-2-naphthoic acid
T0556CAS 2471-70-7
6-Methoxy-2-naphthoic acid is an modulator of NMDAR.
Ifenprodil Tartrate
T1186CAS 23210-58-4
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
Riluzole
T0349CAS 1744-22-5
Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
Anestan
T0954CAS 151-67-7
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
L701324
T1909CAS 142326-59-8
L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
MDL 29951
T1897CAS 130798-51-5
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
QNZ46
T2362CAS 1237744-13-6
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
Eliprodil
T1751CAS 119431-25-3
Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has ...
PEAQX
T4171CAS 459836-30-7
PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 ...
Quinolinic acid
T4096CAS 89-00-9
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
DL-AP5
T22733CAS 76326-31-3
NMDA antagonist
(R)-Serine
T8394CAS 312-84-5
(R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263CAS 569-83-5
Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
4-oxo-1,4-dihydroquinoline-2-carboxylic acid
T8626CAS 13593-94-7
4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
ZL006
T17293CAS 1181226-02-7
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
Perzinfotel
T16473CAS 144912-63-0
Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with ne...
NKH477
T16332CAS 138605-00-2
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 s...
D-AP5
T10930CAS 79055-68-8
D-AP5 is a NMDA receptor antagonist.
TCN213
T8450CAS 556803-08-8
TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
UBP551
T8351CAS 89-35-0
UBP551 is a potent and selective NMDA receptors modulator.
Bacopaside I
TN1420CAS 382148-47-2
Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/P...
TCN-201
T7870CAS 852918-02-6
TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
Procyclidine hydrochloride
T4979CAS 1508-76-5
Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
Flutriafol
T7867CAS 76674-21-0
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
Glypromate
T7778CAS 32302-76-4
Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
Ibotenic acid
TQ0279CAS 2552-55-8
Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
Traxoprodil
TQ0233CAS 134234-12-1
Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
Transcrocetinate disodium
TQ0027CAS 591230-99-8
Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
Rapastinel Trifluoroacetate
T5819CAS 1435786-04-1
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
Spermidine hydrochloride
T5080CAS 334-50-9
Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
1-Aminocyclopropanecarboxylic acid
T4752CAS 22059-21-8
1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from s...
D-Aspartic acid
T4885CAS 1783-96-6
D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA ...
Radiprodil
T5385CAS 496054-87-6
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic...
Sarcosine
T6975CAS 107-97-1
Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.