NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat No.	product name
T0015	Mephenesin	Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T0015	Mephenesin	Mephenesin is a centrally acting muscle relaxant with a short duration of action.
T0051	Urethane	Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0349	Riluzole	Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
T0556	6-Methoxy-2-naphthoic acid	6-Methoxy-2-naphthoic acid is an modulator of NMDAR.
T0802	Procaine hydrochloride
T0954	Anestan	Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T10930	D-AP5	D-AP5 is a NMDA receptor antagonist.
T1186	Ifenprodil Tartrate	Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T1308	Orphenadrine hydrochloride	Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T1324	Phosphoserine	Phosphoserine is the phosphoric acid ester of serine.
T1443	Memantine hydrochloride	Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T16332	NKH477	NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 s...
T16473	Perzinfotel	Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with ne...
T17293	ZL006	ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T1751	Eliprodil	Eliprodil(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has ...
T1897	MDL 29951	MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T1909	L701324	L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T1946	Felbamate	Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T22733	DL-AP5	NMDA antagonist
T2362	QNZ46	QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T3320	Dizocilpine Maleate	(+)-MK-801 is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug ha...
T3486	3-MATIDA	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGl...
T4096	Quinolinic acid	Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T4171	PEAQX	PEAQX(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 ...
T4225	Dextrorphan tartrate	Dextrorphan D-tartrate is a noncompetitive NMDA glutamate receptor antagonist.
T4752	1-Aminocyclopropanecarboxylic acid	1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from s...
T4885	D-Aspartic acid	D-Aspartic acid (D-Asp) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA ...
T4979	Procyclidine hydrochloride	Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
T5080	Spermidine hydrochloride	Spermidine, a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
T5385	Radiprodil	Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic...
T5819	Rapastinel Trifluoroacetate	Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties.
T6259	Dizocilpine	MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
T6352	(-)-MK 801 Maleate	MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T6504	Flupirtine maleate	Flupirtine maleate, a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal po...
T6608	NMDA	N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
T6975	Sarcosine	Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
T7778	Glypromate	Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
T7867	Flutriafol	Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
T7870	TCN-201	TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T8351	UBP551	UBP551 is a potent and selective NMDA receptors modulator.
T8394	(R)-Serine	(R)-Serine is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T8450	TCN213	TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T8626	4-oxo-1,4-dihydroquinoline-2-carboxylic acid	4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
TN1420	Bacopaside I	Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/P...
TN1432	Bacopasaponin C	Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
TN2641	15-Methoxypinusolidic acid	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
TQ0027	Transcrocetinate disodium	Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
TQ0233	Traxoprodil	Traxoprodil (CP101,606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
TQ0279	Ibotenic acid	Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.