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NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

CNS-5161 hydrochloride
T10852160756-38-7In house
CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor ion channel site to produce a noncompetitive blockade of the actions of glutamate.
  • $509
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TargetMol | Inhibitor Hot
AV-101
T26686153152-32-0In house
AV-101 (4-Cl-KYN) , a prodrug antagonist at the glycine site of the NMDA receptor, has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP monkeys.
  • $192
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D-AP5
T1093079055-68-8
D-AP5 (D-APV) is an NMDA receptor antagonist.
  • $30
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Dalzanemdor
T628391629853-48-0In house
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
  • $670
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Dizocilpine
T625977086-21-6
MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
  • $35
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Transcrocetinate disodium
TQ0027591230-99-8
Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
  • $38
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Pregnenolone monosulfate
T125361247-64-9
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.
  • $46
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CGP 78608 hydrochloride
T107811135278-54-4In house
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1 GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
  • $87
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Lanicemine dihydrochloride
T60471153322-06-6In house
Lanicemine dihydrochloride (AZD-6765 dihydrochloride) is a low-capture NMDA channel blocker with antidepressant activity and can be used to study neurological diseases.
  • $30
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R-(+)-EU-1180-453
T696112488764-06-1In house
R-(+)-EU-1180-453 is a novel GluN2C D selective NMDAR-positive modulator for the study of neurological disorders.
  • $413
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Riluzole
T03491744-22-5
Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
  • $33
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Dizocilpine Maleate
T332077086-22-7
Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role.
  • $32
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Delucemine Hydrochloride
T27143186495-99-8In house
Delucemine Hydrochloride (Delucemine) is a polyamine NMDA receptor antagonist used in the study of neurological disorders such as depression and Alzheimer's disease.
  • $293 TargetMol
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DL-AP5
T2273376326-31-3
DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.
  • $42
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NMDA
T66086384-92-5
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors.
  • $35
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Ibotenic acid hydrate
T6901760573-88-8
Ibotenic acid hydrate ((RS)-Ibotenic acid hydrate) is an excitatory amino acid receptor agonist that primarily exerts its effects by activating glutamate receptors, such as NMDA receptors. Ibotenic acid hydrate can be extracted from the fly agaric mushroom (Amanita muscaria).
  • $293
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MRZ 2-514
T12110202808-11-5
MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.
  • $88
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Alaproclate
T6901360719-82-6In house
Alaproclate is a non-competitive NMDA receptor antagonist and a new selective 5-HT uptake inhibitor for the study of depression and dementia.
  • $293
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Urethane
T005151-79-6
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
  • $29
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Indantadol HCl
T27606202914-18-9
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
  • $195
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Neboglamine hydrochloride
T606122759182-59-5In house
Neboglamine (CR-2249, XY-2401) hydrochloride, an orally active positive modulator of the NMDA receptor glycine site, can be used in schizophrenia research [1].
  • $68 TargetMol
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NP10679
T734472914889-88-4In house
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, and may be useful in the study of epilepsy and ischemic stroke.
  • $293 TargetMol
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Orphenadrine
T6859983-98-7In house
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagonist of central and peripheral muscarinic receptors. Attenuation is blocked by mutations in pore residues Y652 or F656. Orphenadrine has antispasmodic, analgesic, and anticholinergic activity and protects against glutamatergic neurotoxicity in vitro and in vivo.Orphenadrine has inhibitory effects on sodium channels and can be used in the treatment of Parkinson's disease.
  • $52
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SDZ 220-040
T23344174575-40-7In house
SDZ 220-040 is a selective mammalian NMDA receptor antagonist that induces a partially gravity-free mode of root growth.
  • $62
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