NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat. No.	Product name	CAS No.	Purity
T16332	NKH477	138605-00-2	98%
T16332	NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 sh...
T16473	Perzinfotel	144912-63-0	98%
T16473	Perzinfotel displays high affinity (IC50=30 nM) for the glutamate site. Perzinfotel is an effective, selective, and competitive NMDA receptor antagonist with neu...
T8447	Ro 8-4304	195988-65-9	98%
T8447	Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
T22654	Selfotel	110347-85-8	98%
T22654	NMDA receptor antagonist
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	569-83-5	98%
TN5263	Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
TN2641	15-Methoxypinusolidic acid	769928-72-5	98%
TN2641	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
T3407	Rapastinel	117928-94-6	98%
T3407	Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T60237	L-Cysteine S-sulfate	1637-71-4	98%
T60237	L-Cysteine S-sulfate is a potent agonist of N-methyl-d-aspartate (NMDA) glutamatergic receptors. L-Cysteine S-sulfate is the cystine lyase substrate.
T7778	Glypromate	32302-76-4	98%
T7778	Glypromate is a neuroprotective agent, is a weak NMDA receptor agonist
T25196	BZAD01	305339-41-7	98%
T25196	BZAD01 is an antagonist of GluN2B subtype-selective NMDA.
T3407L	Rapastinel acetate	491872-39-0	98%
T3407L	Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
T12234	NMDA-IN-1	700878-19-9	98%
T12234	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
TQ0279	Ibotenic acid	2552-55-8	98%
TQ0279	Ibotenic acid has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.
T22900	L-701252	151057-13-5	98%
T22900	L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral isch...
T22517	5,7-Dichlorokynurenic acid	131123-76-7	98%
T22517	NMDA receptor antagonist
T20571	Cis-PDA	46026-75-9	98%
T20571	cis-PDA, a general ionotropic receptor antagonist, acts by blocking NMDA, AMPA, and kainate mediated responses. It also acts as a partial NMDA receptor agonist.
T22542	1-Aminocyclobutanecarboxylic acid	22264-50-2
T22542	1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T4096	Quinolinic acid	89-00-9
T4096	Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T22733	DL-AP5	76326-31-3
T22733	NMDA antagonist
T8459	DNQX disodium salt	1312992-24-7	100%
T8459	DNQX Disodium is a water-soluble form of selective antagonist of non-NMDA receptor