tolerance — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4508	Glycyl-L-Histidyl-L-Lysine		Others
	Glycyl-L-histidyl-L-lysine is a liver cell growth factor and an asynthetic hepatotrophic agent that stimulates hepatic erythropoietic factor production.		Others
T2014	CCG-1423	CCG1423	LRRK2 , Rho , Ras
	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.		LRRK2 , Rho , Ras
PDK0101	4-Methylcinnamic acid		Antifungal
	4-Methylcinnamic acid is a cinnamic acid analog that can be used as an intervention catalyst to overcome antifungal tolerance. 4-Methylcinnamic acid can improve the potency of cell wall-disrupting agents.		Antifungal
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
T5S0669	Bergamottin	5-Geranoxypsoralen,Bergamotine,Bergaptin	P450
	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A^ydiabetic mice.		P450
T7397	GSK547	GSK'547	RIP kinase
	GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.		RIP kinase
T9790	Lactoferrin	Lactoferrin (Bovine)	Endogenous Metabolite
	Lactoferrin is secreted by mammals and displays extensive biological effects including boosting the cold tolerance of a well-applied probiotic strain.		Endogenous Metabolite
T2740	Trans-Cinnamic acid	Isocinnamic acid,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,Myricitrine	Endogenous Metabolite , Antibacterial
	trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.		Endogenous Metabolite , Antibacterial
T5S0662	Gelsemine	Gelsemin	Antioxidant
	1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cance...		Antioxidant
T4785	Oxfenicine	4-Hydroxy-L-phenylglycine	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistanc...		Others
T13692	Ferric maltol	Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate	Others
	Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) is a ferric, non-salt-based oral iron formulation demonstrating improved tolerance in patients with previous intolerance to other iron formulations.		Others
T24695	Quinabactin	LC-66C6,ABA mimics 1,AM1,LC66C6,LC 66C6	Others
	Quinabactin（LC-66C6） is a potent sulfonamide abscisic acid ABA agonist.Quinabactin promotes guard cell closure, inhibits water loss, suppresses seed germination, and improves drought tolerance in adult Arabidopsis thalia...		Others
T27806	Lecozotan HCl	SRA-333,SRA333,SRA 333,Lecozotan hydrochloride	5-HT Receptor
	Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. ...		5-HT Receptor
T61202	TDO-IN-1		Others
	TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which inhibits indoleamine-2,3-dioxygenase.TDO-IN-1 has antitumor activity and is able to act by reversing local immune t...		Others
T21979	P32/98 (hemifumarate)
	P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32...
T3312	AM-2394	AM2394	Glucokinase
	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...		Glucokinase
T38273	Paclobutrazol	(2R,3R)-Paclobutrazol,(R,R)-paclobutrazol,2R,3R-Paclobutrazol	Antifungal
	Paclobutrazol ((R,R)-paclobutrazol) is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.1,2It also has antifungal activities.3PBZ, which is transported acropetally in...		Antifungal
T3849	Kinsenoside	(+)-Kinsenoside	Apoptosis , Nrf2
	Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou...		Apoptosis , Nrf2
T62238	AMPK activator 4		AMPK
	AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in nor...		AMPK
T0056	Oxeladin citrate		Others
	Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of add...		Others