c3a

C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.

C3a (70-77) is an octapeptide that corresponds to the COOH terminus of C3a.

C3a 70-77 acetate is the octapeptide acetate corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.

C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a.

C3a (70-77) (TFA) (Complement 3a (70-77) TFA) is an octapeptide derived from the COOH-terminus of Complement 3a, exhibiting 1–2% C3a biological activity.

SB290157 trifluoroacetate is a potent and selective antagonist of the C3a receptor, with an IC50 of 200 nM.

JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.

C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide.

(Trp63, Trp64)​-C3a(63-77) is a C3a synthetic analogue peptide that exhibits Ca 2+ stimulating efficacy in human neutrophils, as well as hC3aR or mC3aR expressing RBL-2H3 cells, with EC50 values of 9.5, 2.0, and 0.8 nM, respectively [1].

Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.

Recombinant APOBEC3A (A3A) Protein is a single-domain cytidine deaminase with antiviral properties that deaminates cytidine into uracil, allowing for specific detection of DNA methylation levels. This protein is recombinantly expressed in Escherichia coli and is suitable for bisulfite-free whole-genome sequencing of 5-hydroxymethylcytosine (e.g., ACE-Seq) and cytidine deamination.

ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.

5N-Boc-3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrozole ,with CAS No. 398491-59-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5N-Boc-3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrozole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine and extraendocrine properties.

8-Amino-3-Boc-3-azabicyclo[3.2.1]octane ,with CAS No. 1330763-51-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 8-Amino-3-Boc-3-azabicyclo[3.2.1]octane provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Boc-3-azabicyclo[3.1.0]hexane-1-carboxylic acid ,with CAS No. 1363381-55-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Boc-3-azabicyclo[3.1.0]hexane-1-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Boc-3-aminomethyl-3-hydroxypiperidine ,with CAS No. 1308384-31-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Boc-3-aminomethyl-3-hydroxypiperidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker used in PROTAC synthesis [1].

TCO-C3-PEG3-C3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-C1-PEG3-C3-amine (TFA) is a polyethylene glycol (PEG) linker essential for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Biotin-PEG4-amino-t-Bu-DADPS-C3-alkyne serves as a PEG-based linker for PROTAC synthesis [1].

N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker used in PROTAC synthesis [1].