antibodies

B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.

Oxazolone is a haptenating agent that can induce models of acute or chronic colitis and atopic dermatitis. It activates Th1 Th2 responses, leading to weight loss and diarrhea, and the resulting inflammation can be alleviated by anti-IL-4 antibodies, anti-TNF-α antibodies, or IL-13R2α-Fc fusion proteins. It is also suitable for studying gene expression related to inflammatory bowel disease in zebrafish.

Macropa-NH2 is a bifunctional analog of macropa, a carrier molecule that is often coupled to antibodies and is often used as a chelator in cancer research.

VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

ABBV-969 Payload (Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT) is a drug-linker conjugate for the synthesis of ADCs containing a Topo I (Topoisomerase 1) inhibitor molecule and a linker molecule, which can be coupled with anti-c-Met antibodies to form ABBV- 969.

Fmoc-Ala-Ala-Asn(Trt)-OH, a cleavable linker essential in ADC (Antibody-Drug Conjugate) synthesis, facilitates the attachment of cytotoxic drugs to antibodies for precise delivery to targeted cells or proteins. Its cleavable properties ensure controlled drug release, thereby optimizing the efficacy of the ADC.

fmoc-L-2-cyanophenylalanine is a derivative of the amino acid phenylalanine. Due to its excellent reactivity and stability, it is widely used in peptide synthesis, as well as in the synthesis of a variety of other biologically active molecules, such as peptide hormones, enzymes and antibodies.

Rhodopsin Epitope Tag acetate is a 9-amino acid peptide representing C terminus of bovine rhodopsin widely used as an epitope tag. A number of anti-rhodopsin antibodies can recognize this epitope.

DM3-SMe, a maytansine derivative and tubulin inhibitor, acts as the cytotoxic component in antibody-drug conjugates (ADCs). It can bind to antibodies through disulfide bonds or stable thioether bonds and demonstrates high in vitro cytotoxic activity with an IC50 of 0.0011.

Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable, 4-unit PEG linker used in antibody-drug conjugation (ADC) to attach antibodies to drugs.

Ald-Ph-amido-PEG2-C2-NHS ester is a non-cleavable, 2-unit PEG linker used in antibody-drug conjugation (ADC) for attaching antibodies to drugs.

Aminoethyl-SS-propionic acid is an ADC linker compound employed in ADC synthesis [1]. It functions as a cleavable linker in the conjugation of antibodies with drugs, allowing for targeted drug delivery.

Azido-PEG4-CH2-Boc, a four-unit cleavable polyethylene glycol (PEG) linker compound, is used in the synthesis of antibody-drug conjugates (ADCs) [1] and PROTACs [2]. Characterized by its azide functional group and PEG backbone, it facilitates drug-antibody conjugation in ADCs and enables PROTAC synthesis using PEG and alkyl ether moieties.

BDP FL DBCO, a cleavable linker crucial in ADC synthesis, connects cytotoxic drugs to antibodies for targeted delivery to cells or proteins. Its cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Biotin Hydrazide is a carbonyl-reactive biotinylation reagent and carbonyl probe, ideal for labeling mouse monoclonal antibodies, lectins, sugars, unpaired cytosine residues in nucleic acids, and glycoproteins.

Bis-PEG1-NHS ester is a non-cleavable and 1-unit PEG ADC linker for the synthesis of antibody-coupled active molecules (ADCs).

Boc-Cystamine is a cleavable linker vital in ADC synthesis. Boc-Cystamine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Fmoc-NH-ethyl-SS-propionic NHS ester is a cleavable linker for antibody-drug conjugates (ADCs)[1], used in the synthesis of ADCs to facilitate the covalent attachment of drugs to antibodies through stable amide bond formation.

JNJ4796 is an orally active fusion inhibitor of the influenza virus, inhibiting hemagglutinin (HA)-mediated fusion to neutralize the influenza A group 1 virus. JNJ4796 mimics the functionality of broadly neutralizing antibodies (bnAbs).

m-PEG8-Amine is a cleavable linker integral to ADC synthesis, joining cytotoxic drugs to antibodies to enable precise delivery to cells or proteins. Its cleavable nature ensures controlled drug release, thereby optimizing ADC effectiveness.

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2], serving as a cleavable ADC linker to facilitate drug-antibody conjugation for targeted delivery [2].

Propargyl-PEG1-NHS ester is a non-cleavable 1-unit PEG linker used in antibody-drug conjugation (ADC) to link antibodies with drugs.

Propargyl-PEG4-NHS ester is a non-cleavable 4-unit PEG linker used in antibody-drug conjugation (ADC) to link antibodies with drugs.

Tr-PEG4-OH is a non-cleavable tetraethylene glycol ADC linker used in ADC synthesis for the conjugation of antibodies and drugs.