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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6641 | Rilmenidine Phosphate | Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor | |
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension. | |||
T1448 | Dasatinib | BMS-354825 | Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy |
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitumor activity and is used in the treatment of leukemia and ly... | |||
T13224 | Tubulin inhibitor 6 | iHAP1 | Microtubule Associated |
Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines. | |||
T16545 | Pivanex | Pivalyloxymethyl butyrate,AN-9 | Apoptosis , HDAC , Bcr-Abl |
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis. | |||
T0974 | Novobiocin Sodium | Albamycinsodium,Cathomycin,Albamycin | Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy |
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim... | |||
T24838 | Stafib-1 | Stafib 1,Stafib1 | STAT |
Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM. | |||
T2394 | Pixantrone dimaleate | BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate | Topoisomerase |
Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug. | |||
T1448L | Dasatinib monohydrate | BMS-354825 Monohydrate | Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy |
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit... | |||
T3138 | Astaxanthin | β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin | Reactive Oxygen Species , PPAR |
Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aqu... | |||
T5858 | Sertindole | Lu 23-174 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy |
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) | |||
T1511 | Daunorubicin hydrochloride | Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin | Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy |
Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis. | |||
T6018 | Zosuquidar trihydrochloride | Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride | P-gp |
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. | |||
T16940 | STAT5-IN-2 | Apoptosis , STAT | |
STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively). | |||
T2539 | Fingolimod hydrochloride | Fingolimod (FTY720) HCl,FTY720 | TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor |
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells). | |||
T1937 | Spautin-1 | Spautin 1 | Apoptosis , DUB , Autophagy |
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. | |||
T13226 | Tubulin inhibitor 8 | Microtubule Associated | |
Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively. | |||
T74186 | PROTAC-O4I2 | Apoptosis , PROTACs | |
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells. | |||
T12341 | P-gp inhibitor 1 | Others , P-gp | |
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells). | |||
T7939 | Fingolimod | FTY-720A,FTY-720 | S1P Receptor , PAK , LPL Receptor |
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). | |||
T28475 | Pyrazoloacridine | PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 | Apoptosis , Topoisomerase |
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity. |