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Search Result

Search Results for " dub "

Targets

DUB DUB

19

Compounds

2

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T11112 DUB-IN-3 DUB
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.
T11111 DUB-IN-2 DUB
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
T11110 DUB-IN-1 DUB
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
T79672 DUB-IN-7
DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].
T2005 Dubermatinib TP0903 Apoptosis , TAM Receptor
Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.
T39213 Seco-DUBA hydrochloride
Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.
T82577 Desmethyl Vc-seco-DUBA
Desmethyl Vc-seco-DUBA, a compound comprising a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA), is utilized in the synthesis of antibody-drug conjugates (ADCs) [1].
T77189 Sudubrilimab
Sudubrilimab (HS636), an Ig G1-kappa monoclonal antibody targeting PDL1, is engineered with a TGF-β1 receptor II ectodomain (TGFBR2-ECD) fused to its C-terminus. This design enables Sudubrilimab to simultaneously inhibit...
T38611 Seco-DUBA
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).
T79757 Meliadubin B NO Synthase
Meliadubin B, a natural triterpenoid, effectively inhibits inflammatory responses by suppressing superoxide anion generation in human neutrophils (EC 50 of 5.54 μM) as well as inducible nitric oxide synthase activity. Ad...
T18362 Vc-seco-DUBA Others
Vc-seco-DUBA is a drug-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco[1].
T4067 VLX1570 DUB
VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.
T14852 C527 DUB
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
T6300 Degrasyn WP1130 Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri...
T11485 GSK2643943A DUB
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
T6697 TCID UCH-L3 Inhibitor DUB
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
T1862 PR-619 PR 619,2,6-Diamino-3,5-dithiocyanopyridine Apoptosis , DUB , Autophagy
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
T73461 BAY-805
BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21 . BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes .
T69690 XL-188
XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Inc...

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (2)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
Cat No. Product Name Species Expression System
TMPH-01681 METTL4 Protein, Human, Recombinant (His & Myc) Human E. coli
N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U...
TMPH-01273 TRIP12 Protein, Human, Recombinant (His & Myc) Human E. coli
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a...
Cat No. Product Name
L8600 Ubiquitination Compound Library

214 compounds
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；

Libraries

Ubiquitination Compound Library
L8600
Compounds: 214
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