DHFR

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11→q22 region of chromosome 5.[7] Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar.

Cat. No.	Product name	CAS No.	Purity
T13390	ZD 7155(hydrochloride)	146709-78-6	98%
T13390	ZD 7155 hydrochloride is an antagonist of angiotensin II receptor type 1 (AT1 receptor).
T11921	LY 222306	154446-98-7	98%
T11921	LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
T14147	Pelitrexol	446022-33-9	98%
T14147	Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.
T17257	WR99210	47326-86-3	98%
T17257	WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:<...
T16009	Managlinat dialanetil	280782-97-0	98%
T16009	Managlinat dialanetil is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase). It is used for the treatment of type 2 diabetes.
T19858	Brodimoprim	56518-41-3	98%
T19858	Brodimoprim is a structural analog of trimethoprim. Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic ...
T36692	Fanotaprim	2120282-75-7	98%
T36692	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. ...
T15826	Lometrexol	106400-81-1	98%
T15826	Lometrexol, an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA...
T4558	Trioxsalen	3902-71-4	100%
T4558	Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
T1326	Gentamicin sulfate	1405-41-0	651u/mg
T1326	Gentamycin Sulfate is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.
T0738	Urea	57-13-6	98%
T0738	Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
T6120	Pralatrexate	146464-95-1	98.12%
T6120	Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic a...
T0836	Sulfadoxine	2447-57-6	98.36%
T0836	Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T6226	Pemetrexed disodium hemipenta hydrate	357166-30-4	99.16%
T6226	Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is ...
T2204	Diaveridine	5355-16-8	99.19%
T2204	Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cel...
T15827	LY 345899	10538-99-5	99.69%
T15827	LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHF...
T0849	Pyrimethamine	58-14-0	99.74%
T0849	Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
T0748	Sulfameter	651-06-9	99.85%
T0748	Sulfameter is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
T1153	Trimethoprim	738-70-5	99.88%
T1153	Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochr...
T0189L	Pemetrexed disodium	150399-23-8	99.92%
T0189L	Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...