DHFR

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11→q22 region of chromosome 5.[7] Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar.

Cat No.	product name
T0189	Pemetrexed acid	Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T0189L	Pemetrexed disodium	Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...
T0738	Urea	Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
T0748	Sulfameter	Sulfameter is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
T0836	Sulfadoxine	Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T0849	Pyrimethamine	Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
T1153	Trimethoprim	Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...
T11921	LY 222306	LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
T1326	Gentamycin sulfate	Gentamycin Sulfate is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.
T13390	ZD 7155(hydrochloride)	ZD 7155 hydrochloride is an antagonist of angiotensin II receptor type 1 (AT1 receptor).
T14147	Pelitrexol	Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.
T15827	LY 345899	LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTH...
T16009	Managlinat dialanetil	Managlinat dialanetil is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase). It is used for the treatment of type 2 diabetes.
T17257	WR99210	WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:...
T2204	Diaveridine	Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian ce...
T4558	Trioxsalen	Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation...
T6120	Pralatrexate	Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic ...
T6226	Pemetrexed Disodium Hydrate	Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is...

Cat No.

product name

T0189

Pemetrexed acid

Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

T0189L

Pemetrexed disodium

Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothel...

T0738

Urea

Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...

T0748

Sulfameter

Sulfameter is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.

T0836

Sulfadoxine

Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.

T0849

Pyrimethamine

Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.

T1153

Trimethoprim

Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytoch...

T11921

LY 222306

LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.

T1326

Gentamycin sulfate

Gentamycin Sulfate is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.

T13390

ZD 7155(hydrochloride)

ZD 7155 hydrochloride is an antagonist of angiotensin II receptor type 1 (AT1 receptor).

T14147

Pelitrexol

Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.

T15827

LY 345899

LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTH...

T16009

Managlinat dialanetil

Managlinat dialanetil is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase). It is used for the treatment of type 2 diabetes.

T17257

WR99210

WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:...

T2204

Diaveridine

Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian ce...

T4558

Trioxsalen

Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation...

T6120

Pralatrexate

Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic ...

T6226

Pemetrexed Disodium Hydrate

Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is...