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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries Approved / Repurposing Characteristic Bioactive Libraries COVID-19 / SARS-CoV-2 Disease Focused Target / Pathway Focused Natural Product Libraries Characteristic Natural Product Libraries Natural Compound Library for HTS Natural Product Based Library Selectable Natural Compound Library Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Focused Bioactive Libraries Approved / Repurposing Characteristic Bioactive Libraries COVID-19 / SARS-CoV-2 Disease Focused Target / Pathway Focused
Natural Product Libraries Characteristic Natural Product Libraries Natural Compound Library for HTS Natural Product Based Library Selectable Natural Compound Library
Fragment Libraries Drug-fragment Library Featured Fragment Library High Solubility Fragment Library Custom Compound Library
Metabolism DHFR

DHFR

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11→q22 region of chromosome 5.[7] Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar.
Cat No. product name
T17257 WR99210 WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:<...
T0738 Urea Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
T1326 Gentamycin sulfate Gentamycin Sulfate is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.
T6120 Pralatrexate Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic a...
T0189L Pemetrexed disodium Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
T0836 Sulfadoxine Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T6226 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is ...
T2204 Diaveridine Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cel...
T0849 Pyrimethamine Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
T11921 LY 222306 LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
T0748 Sulfameter Sulfameter is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
T1153 Trimethoprim Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochr...
T4558 Trioxsalen Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
T14147 Pelitrexol Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.
T13390 ZD 7155(hydrochloride) ZD 7155 hydrochloride is an antagonist of angiotensin II receptor type 1 (AT1 receptor).
T15827 LY 345899 LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHF...
T16009 Managlinat dialanetil Managlinat dialanetil is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase). It is used for the treatment of type 2 diabetes.
T0189 Pemetrexed acid Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
WR99210
T17257CAS 47326-86-3
WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:<...
Urea
T0738CAS 57-13-6
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
Gentamycin sulfate
T1326CAS 1405-41-0
Gentamycin Sulfate is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.
Pralatrexate
T6120CAS 146464-95-1
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic a...
Pemetrexed disodium
T0189LCAS 150399-23-8
Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli...
Sulfadoxine
T0836CAS 2447-57-6
Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
Pemetrexed Disodium Hydrate
T6226CAS 357166-30-4
Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is ...
Diaveridine
T2204CAS 5355-16-8
Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cel...
Pyrimethamine
T0849CAS 58-14-0
Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
LY 222306
T11921CAS 154446-98-7
LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
Sulfameter
T0748CAS 651-06-9
Sulfameter is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
Trimethoprim
T1153CAS 738-70-5
Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochr...
Trioxsalen
T4558CAS 3902-71-4
Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation ...
Pelitrexol
T14147CAS 446022-33-9
Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.
ZD 7155(hydrochloride)
T13390CAS 146709-78-6
ZD 7155 hydrochloride is an antagonist of angiotensin II receptor type 1 (AT1 receptor).
LY 345899
T15827CAS 10538-99-5
LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHF...
Managlinat dialanetil
T16009CAS 280782-97-0
Managlinat dialanetil is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase). It is used for the treatment of type 2 diabetes.
Pemetrexed acid
T0189CAS 137281-23-3
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
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