steroidal

Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone.

Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).

Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing plants found in subtropical regions. It was one of the first sapogenins to be identified, and the first spirostan steroid to be identified as such.

Dihydrocholesterol is a derivatized steroidal compound that inhibits cholesterol absorption.

(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.

trans-Stilbene (1,2-Diphenylethylene (trans)) is a natural product used in the manufacture of dye lasers, optical brighteners, and non-steroidal synthetic estrogens.

Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.

Ophiopogonin C is a natural product isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside.

Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.

Yibeissine is a natural steroidal alkaloid isolated from the bulb of Fritillaria pallioiflora Schren.

Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen ethinyl estradiol.

Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotecti

Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.

Cyclobuxine D, a steroidal alkaloid extracted from Buxus microphylla, exhibits significant bradycardia effects on rat hearts and inhibits acetylcholine and Ba++-induced longitudinal muscle contractions in isolated rabbit jejunum.

β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.

Dehydrolycopene is a major steroidal sugar alkaloid (SGAs), which is mainly found in mature green fruits, leaves and flowers of tomatoes. Dehydrotomato is targeted at bacteria, fungi, insects and animals.

Lirioprolioside B, a steroidal glycoside, is isolated from the underground organs of Liriope spicata var. prolifera.

Conessine (Conessinum), a steroidal alkaloid isolated from Holarrhena floribunda, interacts with the histamine H3 receptor and has anti-malarial activity.

Protodioscin (Furostanol I) is a major steroidal saponin in dioscoreae rhizome, with anti-hyperlipidemia, anti-cancer properties.

Pseudoprotogracillin is a steroidal saponin extracted from Dioscoreae.

Protogracillin, a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW), may inhibit platelet aggregation (PAG) and thrombosis, potentially reducing the risk of cardiovascular diseases through its anti-thrombotic action.

Timosaponin A1, a coprostane-type steroidal saponin, is found in Rhizoma Anemarrhenae.

Pennogenin steroidal saponins could be utilized to develop anticancer medicines.

Aspafilioside A is a steroidal saponin isolated from the root of Asparagus filicinus.