recruitment — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40548	NH-3		Thyroid hormone receptor(THR)
	NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the...		Thyroid hormone receptor(THR)
T21938	AS-041164		PI3K
	AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory e...		PI3K
T26869	BMS-986122	BMS 986122	Opioid Receptor
	BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...		Opioid Receptor
T18064	Lenalidomide-Br		Ligand for E3 Ligase
	Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a...		Ligand for E3 Ligase
T8497	SX-682		CXCR
	SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.		CXCR
T16850	SB-265610	GSK-CXCR2	CXCR
	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...		CXCR
T28073	MLS1547	MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor
	MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa...		Dopamine Receptor
T4657	WHI-P97		JAK
	WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...		JAK
T14667	BLT-1		Others , HCV Protease
	BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.		Others , HCV Protease
T40028	(S,R,S)-AHPC		Ligand for E3 Ligase
	(S,R,S)-AHPC is a VHL ligand that used in the recruitment of the VHL protein.		Ligand for E3 Ligase
T40503	Thalidomide-5-methyl		Ligand for E3 Ligase
	Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.		Ligand for E3 Ligase
T22021	ACHP	IKK-2 Inhibitor VIII	IκB/IKK
	ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression thro...		IκB/IKK
T18831	Thalidomide-propargyl		Others , Ligand for E3 Ligase
	Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs.		Others , Ligand for E3 Ligase
T7329	C-178		STING
	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.		STING
T7753	Thalidomide-O-COOH	Cereblon ligand 3,E3 ligase Ligand 3,TCE35031	Others , Ligand for E3 Ligase
	Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs.		Others , Ligand for E3 Ligase
T8412	(S,R,S)-AHPC	VH032-NH2,MDK7526,VHL ligand 1	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor.		Others , Ligand for E3 Ligase
T9029	STING-IN-3	C-171	STING
	STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.		STING
TP1922L1	ELA-11 (human) acetate(1784687-32-6 free base)		Apelin receptor , Arrestin
	ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.		Apelin receptor , Arrestin
T77673	7-FluorotryptaMine HCl		GPR , Arrestin
	7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.		GPR , Arrestin
T39988	6'-GNTI dihydrochloride		Opioid Receptor , Akt
	6'-GNTI dihydrochloride is a κ-opioid receptor (KOR) agonist that favors activation of G-protein-mediated signaling over recruitment of β-aspirin 2. 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neur...		Opioid Receptor , Akt