Search Result

Search Results for " osteoporosis "

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T61269	Anti-osteoporosis agent-1
	Anti-osteoporosis agent-1 (comp 4aa) is an effective RPA (replication protein A) inhibitor, demonstrating potency with an IC50 value of 18 μM [1].
T83032	Anti-osteoporosis agent-7
	Compound 133, also known as Anti-osteoporosis agent-7, is a potential anti-osteoporosis agent that exhibits significant inhibition of osteoclast formation.
T78816	Anti-osteoporosis agent-4		NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively inhibits osteoclast formation, demonstrating an IC50 value of...		NF-κB
T10696	CB2 modulator 1		Cannabinoid Receptor
	CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.		Cannabinoid Receptor
T7469	Alendronic Acid	alendronate	Others
	Alendronic Acid (alendronate) is a nonhormonal medication used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.		Others
T39508	KY-02327		Others
	KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti...		Others
T22703	CYM-5520	CYM 5520	S1P Receptor , LPL Receptor
	CYM-5520 is a noncompetitive allosteric agonist of S1P2		S1P Receptor , LPL Receptor
T9917	Denosumab		RANKL/RANK
	Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand		RANKL/RANK
T0308	Etidronic acid	HEDPA,Etidronate,HEDP	Apoptosis , Phosphatase , Others , HBV
	Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.		Apoptosis , Phosphatase , Others , HBV
T1850	Balicatib	AAE581	Cysteine Protease
	Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.		Cysteine Protease
T1210	Sodium etidronate	Didronel	Phosphatase
	Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha...		Phosphatase
T2334	Avanafil	TA1790	PDE
	Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.		PDE
T7839	Lasofoxifene Tartrate	CP-336156	Estrogen Receptor/ERR
	Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator.		Estrogen Receptor/ERR
T21460	Teriparatide acetate	hPTH 1-34 (acetate salt),Parathar acetate,Forteo	Others
	Teriparatide acetate (Forteo) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide acetate is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat...		Others
T6374	Alfacalcidol	Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others
	Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.		Others
T6739	Zoledronic Acid	CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis , Rho , Autophagy
	Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc...		Apoptosis , Rho , Autophagy
T21299	Zoledronic acid monohydrate	zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate	Apoptosis , Others , Autophagy
	Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.		Apoptosis , Others , Autophagy
T12846	SB-423562		CaSR
	SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.		CaSR
T29164	WY-47766	WY47766
	WY-47766, a proton pump inhibitor, is used potentially for the treatment of postmenopausal osteoporosis.
T1599L	Ibandronate sodium	Boniva,Ibandronate sodium salt,Bondronat	HBV , Transferase
	Ibandronate sodium (Boniva) is a synthetic nitrogen-containing bisphosphonate, used for the treatment of osteoporosis.		HBV , Transferase
T6539	Ibandronate sodium monohydrate	Boniva monohydrate,Bondronat monohydrate,Ibandronate sodium,BM-210955,BM-21.0955,RPR-102289A	Apoptosis , Others
	Ibandronate sodium monohydrate (BM-210955) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.		Apoptosis , Others
T19501	Pamidronate disodium pentahydrate		Others
	Pamidronate disodium pentahydrate strengthens bones and prevents osteoporosis.		Others
T1641	Strontium ranelate	Distrontium renelate,S12911	Calcium Channel , CaSR
	Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in...		Calcium Channel , CaSR
T24182	ISX-1	ISX 1	Others
	ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.		Others
T6373	Alendronate sodium hydrate	G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,G-704650 Adronat,Fosamax	Transferase
	Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.		Transferase
TP1040	Calcitonin (salmon)	Calcitonin salmon,Salmon calcitonin	CGRP Receptor
	Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.		CGRP Receptor
T1041	Risedronate Sodium	NE 58095 Sodium,Risedronic Acid Sodium	HBV , Transferase
	Risedronate Sodium (NE 58095 Sodium) is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS.		HBV , Transferase
TP1215	Abaloparatide TFA	BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA	Others
	Abaloparatide TFA (BIM 44058 TFA) is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis like the related drug teriparatide.		Others
TP1040L	Calcitonin（salmon） Acetate(47931-85-1(free base))	Salmon calcitonin	CGRP Receptor
	Calcitonin(salmon)Acetate(47931-85-1(free base))(Salmon calcitonin) , a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.		CGRP Receptor
T67855	ISX-3		Others
	ISX-3 is a potent pro-osteogenic and anti-adipogenic agent. ISX-3 can increase the expression of PPARγ. ISX-3 can be for the research of osteopenia and osteoporosis.		Others
T21535	Parathyroid Hormone (1-34), bovine		Thyroid hormone receptor(THR)
	Parathyroid Hormone (1-34), bovine is a parathyroid hormone (PTH) receptor agonist that is part of the parathyroid hormone family. Parathyroid Hormone (1-34), bovine is used to study osteoporosis and hypoparathyroidism.		Thyroid hormone receptor(THR)
T60554	Schnurri-3 inhibitor-1		Others
	Schnurri-3 inhibitor-1, a potent inhibitor of schnurri-3, is an essential regulator of bone formation in adults that can be used in osteoporosis research. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in...		Others
T77567	BCPA		Others
	BCPA is a non-cytotoxic Pin1 modulator.BCPA modulates osteoclast activation and attenuates the reduction of Pin1 protein, thereby inhibiting RANKL-induced receptor activators of osteoclastogenesis.BCPA is used in the stu...		Others
T8436	Minodronic acid	Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529	Apoptosis , P2X Receptor
	Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the ...		Apoptosis , P2X Receptor
T111959	IFB-088 acetate
	IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein...
T11914	LY88074 Trimethyl ether		Others
	LY88074 Trimethyl ether is useful for inhibiting various conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia.		Others
T31944	Glutamine monofluorophosphate	L-Glutamine monofluorophosphate,G-MFP
	Glutamine monofluorophosphate is used during the fluorotherapy of osteoporosis.
T25700L	Levormeloxifene fumarate
	Levormeloxifene fumarate is an osteoporosis drug and selective estrogen receptor modulator (SERM).
T26041	Ranelic acid
	Ranelic acid is an organic acid capable of chelating metal cations. Strontium ranelate, the strontium salt of Ranelic acid, is utilized to treat osteoporosis and increase bone mineral density.
T28870	Strontium Malonate	NBS-101,NBS 101,NBS101
	Strontium Malonate, a calcium-sensing receptor agonist, is used potentially for the treatment of postmenopausal osteoporosis.
T70305	Zoledronate trisodium hydrate
	Zoledronate trisodium is a Bone Resorption Inhibitor and Osteoporosis Therapy Adjunct
T69778	Iso-Dehydrozingerone
	iso-Dehydrozingerone is a novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice.
T31624	Encaleret	JIT305,JIT 305
	Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.
T27825	LG190178	LG-190178,LG 190178
	LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.
TP1027	Calcitonin, eel TFA (57014-02-5 free base)	Thyrocalcitonin eel (TFA),Calcitonin, eel TFA
	Calcitonin,eel TFA is a thyroid hormone polypeptide that can regulate calcium homeostasis and is widely used in the study of postmenopausal osteoporosis.
T11913	LY88074 Methyl ether		Others
	LY88074 Methyl ether is effective in inhibiting conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia, which occur due to various estrogen-deficient states.		Others
T15749	LGD-2226		Androgen Receptor
	LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporosis, and sexual dysfunction.		Androgen Receptor
T15206	Eldecalcitol	ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	Others
	Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treat...		Others
T16394	ONO-5334		Cysteine Protease
	ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis.		Cysteine Protease
T12687	Raloxifene 6,4'-Bis-β-D-glucuronide		Others
	Raloxifene 6,4'-Bis-β-D-glucuronide is a Raloxifene metabolite. Raloxifene is a selective antagonist of estrogen receptor for the prevention of osteoporosis.		Others

Compounds

Anti-osteoporosis agent-1

T61269

Synonym:

Target:

Anti-osteoporosis agent-7

T83032

Synonym:

Target:

Anti-osteoporosis agent-4

Target: Cannabinoid Receptor

Target: S1P Receptor, LPL Receptor

Synonym: HEDPA,Etidronate,HEDP

Target: Apoptosis, Phosphatase, Others, HBV

Balicatib

T1850

Synonym: AAE581

Target: Cysteine Protease

Lasofoxifene Tartrate

T7839

Synonym: CP-336156

Target: Estrogen Receptor/ERR

Teriparatide acetate

T21460

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo

Target: Others

Alfacalcidol

T6374

Synonym: Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol

Target: Others

Zoledronic Acid

T6739

Synonym: CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa

Target: Apoptosis, Rho, Autophagy

Zoledronic acid monohydrate

T21299

Synonym: zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate

Target: Apoptosis, Others, Autophagy

Synonym: Boniva,Ibandronate sodium salt,Bondronat

Target: HBV, Transferase

Ibandronate sodium monohydrate

T6539

Synonym: Boniva monohydrate,Bondronat monohydrate,Ibandronate sodium,BM-210955,BM-21.0955,RPR-102289A

Target: Apoptosis, Others

Pamidronate disodium pentahydrate

Synonym: Distrontium renelate,S12911

Target: Calcium Channel, CaSR

Alendronate sodium hydrate

T6373

Synonym: G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,G-704650 Adronat,Fosamax

Target: Transferase

Calcitonin (salmon)

TP1040

Synonym: Calcitonin salmon,Salmon calcitonin

Target: CGRP Receptor

Risedronate Sodium

T1041

Synonym: NE 58095 Sodium,Risedronic Acid Sodium

Target: HBV, Transferase

Abaloparatide TFA

TP1215

Synonym: BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA

Target: Others

Calcitonin（salmon） Acetate(47931-85-1(free base))

TP1040L

Synonym: Salmon calcitonin

Target: CGRP Receptor

Parathyroid Hormone (1-34), bovine

T21535

Synonym:

Target: Thyroid hormone receptor(THR)

Schnurri-3 inhibitor-1

Synonym: Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529

Target: Apoptosis, P2X Receptor

LY88074 Trimethyl ether

T11914

Synonym:

Target: Others

Glutamine monofluorophosphate

T31944

Synonym: L-Glutamine monofluorophosphate,G-MFP

Target:

Levormeloxifene fumarate

Synonym: NBS-101,NBS 101,NBS101

Target:

Zoledronate trisodium hydrate

Synonym: JIT305,JIT 305

Target:

LG190178

T27825

Synonym: LG-190178,LG 190178

Target:

Calcitonin, eel TFA (57014-02-5 free base)

TP1027

Synonym: Thyrocalcitonin eel (TFA),Calcitonin, eel TFA

Target: Androgen Receptor

Eldecalcitol

T15206

Synonym: ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target: Cysteine Protease

Raloxifene 6,4'-Bis-β-D-glucuronide

T12687

Synonym:

Target: Others

Cat No.	Product Name	Synonyms	Targets
T83033	Anti-osteoporosis agent-2
	Anti-osteoporosis agent-2 (Compound 10) serves as an inhibitor of osteoclast differentiation induced by RANKL [1].
TN1124	Neoeriocitrin		AChE
	Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.		AChE
T5S1172	Tiliroside	Tribuloside	Antioxidant
	1. Tiliroside (Tribuloside) shows anticarcinogenic activity. 2. Tiliroside shows hepatoprotective activity. 3. Tiliroside shows antioxidant and anti-inflammatory activity, can inhibit neuroinflammation in neurodegenerati...		Antioxidant
T3408	Syringin	Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine	NOS , Autophagy
	Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.		NOS , Autophagy
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide	(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14	Wnt/beta-catenin
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa...		Wnt/beta-catenin
T3906	Epimedin A		Others
	Epimedin A has anti-osteoporosis activities in vivo.		Others
T6S2146	Epimedin B	Epmedin B	Others
	1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts.		Others
TQ0172	2''-O-Rhamnosylicariside II		Others
	2''-O-Rhamnosylicariside II might be beneficial for improving postmenopausal osteoporosis. It shows potent antioxidant activity, with IC50 values of 11.5 ug/mL and 90.5 uM.		Others
TN1076	Oleonuezhenide		Others
	Oleonuezhenide is a natural product from Chinese formula Ligustrum lucidum, exerts neuroprotective effects and also considered as treatment of osteoporosis.		Others
T2O2798	D-(+)-Trehalose	Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,Trehalose	Others , Endogenous Metabolite
	D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.		Others , Endogenous Metabolite
T3130	Testosterone phenylpropionate	Testosterone hydrocinnamate,Retandrol,Testosterone 17-phenylpropionate	Others
	Testosterone phenylpropionate (Testosterone 17-phenylpropionate)is a steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.		Others
T6S2252	Sweroside		Others
	1. Sweroside possesses strong hepatoprotective effect. 2. Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.		Others
T3396	Baohuoside I	Icariside-II,Icariin-II	Apoptosis , CXCR
	Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.		Apoptosis , CXCR
T7106	Menaquinone-4	Vitamin K2,Menaquinone K4	Others , Endogenous Metabolite
	Menaquinone-4 (Vitamin K2) is a vitamin K compound used as a hemostatic agent, and also as adjunctive therapy for the pain of osteoporosis.		Others , Endogenous Metabolite
T3397	Epmedin C	Baohuoside-VI,Epimedin C	Others
	Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteopor...		Others
TN6900	Reptoside		Others
	Reptoside, which can be extracted from the roots and above-ground parts of Cortex Eucommiae and Ajuga chamaepitys (L.) Schreb, is one of the active cyclic enol ether terpene glycosides of Cortex Eucommiae for the treatme...		Others
TN7242	5-Hydroxyvanillin	3,4-Dihydroxy-5-methoxybenzaldehyde	Antifungal
	5-Hydroxyvanillin (3,4-Dihydroxy-5-methoxybenzaldehyde) can be isolated from indica rice and has an inhibitory effect on Staphylococcus aureus, which can be used for the treatment and prevention of osteoporosis.		Antifungal
T5751	Tigogenin		Others
	Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.		Others
T8709	Nandrolone phenylpropionate	Nandrolone phenpropionate	Androgen Receptor
	Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis		Androgen Receptor
T1549	Raloxifene hydrochloride	LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl	Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy
	Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol...
TJS0856	Dalbergin	6-Hydroxy-7-Methoxy-4-Phenylcoumarin	Others
	1. Dalbergin (6-Hydroxy-7-Methoxy-4-Phenylcoumarin) exhibits similar bone conserving effect against bone-loss as estradiol treatment, it as a therapeutic candidate against postmenopausal osteoporosis. 2. Dalbergin preven...		Others
T3S0364	L-Arginine	L-Arg,(S)-(+)-Arginine	IL Receptor , Endogenous Metabolite , NO Synthase
	1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate...		IL Receptor , Endogenous Metabolite , NO Synthase
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T6S2099	Geraniin		Antioxidant , TNF
	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...		Antioxidant , TNF
T7190	Actein		Apoptosis , Akt , JNK , Autophagy
	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...		Apoptosis , Akt , JNK , Autophagy
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T6S1559	Aurantio-obtusin		Others
	1. Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. 2. Aurantio-obtusin, stimulated chemotactic migration of ...		Others
T81761	Morusignin L
	Morusignin L, an active compound, exhibits anti-osteoporosis properties [1] [2].
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
T39445	Korepimedoside C	Epimedin I
	Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively stud...
TMA0132	Dihydrophaseic acid		Others
	Dihydrophaseic acid 3'-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteopo...		Others
TN3753	Dalbergioidin		Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or...		Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
TN1431	Baohuoside VII		Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VI...		Others
TN3144	6,4'-Dihydroxy-7-methoxyflavanone	檀木	ERK , IL Receptor , Antioxidant , TNF , NF-κB , MAPK , Prostaglandin Receptor , JNK , Autophagy
	6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy...
TN4334	Isotaxiresinol		TNF
	Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis indu...		TNF

Natural Products

Anti-osteoporosis agent-2

Synonym: Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine

Target: NOS, Autophagy

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14

Target: Wnt/beta-catenin

2''-O-Rhamnosylicariside II

Synonym: Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,Trehalose

Target: Others, Endogenous Metabolite

Testosterone phenylpropionate

T3130

Synonym: Testosterone hydrocinnamate,Retandrol,Testosterone 17-phenylpropionate

Synonym: Icariside-II,Icariin-II

Target: Apoptosis, CXCR

Menaquinone-4

T7106

Synonym: Vitamin K2,Menaquinone K4

Target: Others, Endogenous Metabolite

Epmedin C

T3397

Synonym: Baohuoside-VI,Epimedin C

Synonym: 3,4-Dihydroxy-5-methoxybenzaldehyde

Nandrolone phenylpropionate

T8709

Synonym: Nandrolone phenpropionate

Target: Androgen Receptor

Raloxifene hydrochloride

T1549

Synonym: LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy

Dalbergin

TJS0856

Synonym: 6-Hydroxy-7-Methoxy-4-Phenylcoumarin

Target: Others

L-Arginine

T3S0364

Synonym: L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

Saikosaponin A

T2768

Synonym:

Target: NF-κB, Antibacterial, Liver X Receptor

Geraniin

T6S2099

Synonym:

Target: Antioxidant, TNF

Actein

T7190

Synonym:

Target: Apoptosis, Akt, JNK, Autophagy

Target: Tyrosinase, ROS, Akt, PI3K, TGF-beta/Smad

6,4'-Dihydroxy-7-methoxyflavanone

TN3144

Synonym: 檀木

Target: ERK, IL Receptor, Antioxidant, TNF, NF-κB, MAPK, Prostaglandin Receptor, JNK, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04178	IL-11 Protein, Mouse, Recombinant	Mouse	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-03488	IL-11 Protein, Human, Recombinant	Human	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-05842	IL-11 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-01395	CTHRC1 Protein, Human, Recombinant (His)	Human	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-03674	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-02726	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-03364	RANKL/TNFSF11/CD254 Protein, Human, Recombinant	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-06623	CB2/CNR2 Protein, Human, Recombinant	Human	HEK293
	Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 are associated with osteoporosis and low bone mineral density (BMD) in case-control studies. There is a possibility that genetic variants of the...
TMPK-00231	Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, ...
TMPK-01296	Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated	Cynomolgus	HEK293
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, ...
TMPK-00217	Siglec-15 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, ...
TMPK-01295	Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)	Cynomolgus	HEK293
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, ...
TMPJ-00079	IL-11 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate ...
TMPJ-00762	ER alpha Protein, Human, Recombinant (His)	Human	E. coli
	Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPY-03260	QPCT Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioact...
TMPY-06826	CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-06775	CTHRC1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-06795	CTHRC1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-04288	CTHRC1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-06561	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-00537	RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-01471	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-03527	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)	Human	HEK293
	Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...

IL-11 Protein, Mouse, Recombinant

TMPY-04178

Species: Mouse

Expression System: E. coli

IL-11 Protein, Human, Recombinant

TMPY-03488

Species: Human

Expression System: E. coli

IL-11 Protein, Cynomolgus, Recombinant

TMPY-05842

Species: Cynomolgus

Expression System: E. coli

CTHRC1 Protein, Human, Recombinant (His)

TMPY-01395

Species: Human

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)

TMPY-03674

Species: Human

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)

TMPY-02726

Species: Mouse

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Human, Recombinant

TMPY-03364

Species: Human

Expression System: HEK293

CB2/CNR2 Protein, Human, Recombinant

TMPY-06623

Species: Human

Expression System: HEK293

Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated

TMPK-00231

Species: Mouse

Expression System: HEK293

Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

TMPK-01296

Species: Cynomolgus

Expression System: HEK293

Siglec-15 Protein, Human, Recombinant (His & Avi)

TMPK-00217

Species: Human

Expression System: HEK293

Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)

TMPK-01295

Species: Cynomolgus

Expression System: HEK293

IL-11 Protein, Mouse, Recombinant (hFc)

TMPJ-00079

Species: Mouse

Expression System: Human Cells

ER alpha Protein, Human, Recombinant (His)

TMPJ-00762

Species: Human

Expression System: E. coli

QPCT Protein, Human, Recombinant (His)

TMPY-03260

Species: Human

Expression System: Baculovirus-Insect Cells

CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-06826

Species: Human

Expression System: HEK293

CTHRC1 Protein, Human, Recombinant (hFc)

TMPY-06775

Species: Human

Expression System: HEK293

CTHRC1 Protein, Mouse, Recombinant (His)

TMPY-06795

Species: Mouse

Expression System: HEK293

CTHRC1 Protein, Rat, Recombinant (His)

TMPY-04288

Species: Rat

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc)

TMPY-06561

Species: Human

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)

TMPY-00537

Species: Cynomolgus

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)

TMPY-01471

Species: Human

Expression System: HEK293

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)

TMPY-03527

Species: Human

Expression System: HEK293

Cat No.	Product Name
L7900	Osteogenesis Compound Library	320 compounds
	A unique collection of 320 osteogenesis related compounds for high throughput and high content screening;
L9600	Peptide Compound Library	800 compounds
	800 peptides can be used in peptide drug development and signaling transduction and mechanism study;

Libraries

Osteogenesis Compound Library

L7900

Compounds: 320

Peptide Compound Library

L9600

Compounds: 800