atp-binding — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8719	SC99		Apoptosis , JAK , STAT
	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...		Apoptosis , JAK , STAT
T6541	Ibutilide Fumarate	Corvert Fumarate,U70226E	Calcium Channel , Sodium Channel
	Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar...		Calcium Channel , Sodium Channel
T8491	Vorolanib	CM082,X-82	VEGFR , PDGFR
	Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.		VEGFR , PDGFR
T3148	MK-571 sodium	L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor , LTR
	MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ...		Leukotriene Receptor , LTR
T6152	PD318088		MEK
	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.		MEK
T24111	GSK3i XIII	GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII	GSK-3
	GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.		GSK-3
TQ0186	Ko 143		BCRP , ABC
	Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).		BCRP , ABC
T15385	Glibornuride		Potassium Channel
	Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.		Potassium Channel
T13547L	AMP-PCP disodium		HSP
	AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM. The binding of AMP-PCP disodium contributes to the formation of an active homodimer of Hsp90.		HSP
T12609	R-10015		LIM Kinase , Reverse Transcriptase
	R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may ...		LIM Kinase , Reverse Transcriptase
T15375	Inavolisib	GDC-0077,RG6114	Apoptosis , PI3K
	Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib exerts its activity by binding to the ATP binding ...		Apoptosis , PI3K
T8864	Thymidylate Kinase Inhibitor, YMU1		Others
	YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site.		Others
T20003	Acridone		Antibacterial , ABC
	Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.		Antibacterial , ABC
T10585	Bozitinib	CBT-101,PLB-1001	c-Met/HGFR
	Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.		c-Met/HGFR
T11348	G907		Antibiotic
	G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli Msb...		Antibiotic
T4487	TNP	IP3K Inhibitor	Others
	TNP (IP3K Inhibitor) is a cell-permeable inhibitor of IP6K1 and IP3K, with IC 50 values of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes [1].		Others
T3650	STO-609 acetate		CaMK
	STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the ATP-binding site. It displays > 80-fold selectivity over CaMK...		CaMK
T6337	RepSox	ALK5 Inhibitor II,SJN 2511,E-616452	ALK , TGF-beta/Smad
	RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.		ALK , TGF-beta/Smad
T10965	DBPR112		EGFR
	DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 can occupy the ATP-binding site. DBPR112 has significant antitumor eff...		EGFR
T7424	NDI-091143		ATP Citrate Lyase
	NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition.		ATP Citrate Lyase