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PARP

T2105 Veliparib dihydrochloride Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
T2124 PJ34 hydrochloride PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
T2484 AZD2461 AZD2461 is a novel PARP inhibitor.
T2591 Veliparib Veliparib (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T3015 Olaparib Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM).
T3231 Niraparib MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-f...
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3649 BGP-15 BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
T4463 Rucaparib Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
T5399 GeA-69 GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
T5860 CK-869 CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.
T6127 Rucaparib Phosphate Rucaparib is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
T6181 UPF 1069 UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
T6197 PJ34 PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
T6224 Iniparib Iniparib (BSI-201) ,a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T6253 Talazoparib Talazoparib is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
T6329 INO-1001 INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
T6339 AG-14361 AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T6578 ME0328 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
T6780 Benzamide Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T6892 Niraparib tosylate MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T6942 Picolinamide Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
T7042 1,5-Isoquinolinediol 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes w...
T9115 Vanillic Acid Vanillic acid is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.
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