HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.

Cat. No.	Product name	CAS No.	Purity
T67788	BAY-43-9695	233255-39-5	98%
T67788	BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.
T27586	IDX184	1036915-08-8	98%
T27586	IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 ...
T26815	BILB-1941	494856-61-0	98%
T26815	BILB-1941 is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.
T28830	Sovaprevir	1001667-23-7	98%
T28830	Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection.
T27696	JTK-109	480462-62-2	98%
T27696	JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
T67787	Adafosbuvir PM	1613589-04-0	98%
T67787	Adafosbuvir PM is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.
T26863	BMS-929075	1217338-97-0	98%
T26863	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic pa...
T68015	Ruzasvir	1613081-64-3	98%
T68015	Ruzasvir is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
T24480	MK-8325	1334314-19-0	98%
T24480	MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability ...
T28762	Setrobuvir	1071517-39-9	98%
T28762	Setrobuvir is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s betw...
TN1033	Sennidin A	641-12-3	98%
TN1033	Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
TN1138	γ-Fagarine	524-15-2	98%
TN1138	gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-i...
TN1034	Sennidin B	517-44-2	98%
TN1034	Sennidin B stimulates glucose incorporation in rat adipocytes.
T5539	GS-443902	1355149-45-9	98%
T5539	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
TN3809	Dehydrojuncusol	117824-04-1	98%
TN3809	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
T12966	Sofosbuvir impurity K	1496552-51-2	98%
T12966	Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12969	Sofosbuvir impurity N	1394157-34-6	98%
T12969	Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12033	Micrococcin P1	67401-56-3	98%
T12033	Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
T12965	Sofosbuvir impurity J	1334513-10-8	98%
T12965	Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12963	Sofosbuvir impurity H	T12963	98%
T12963	Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...