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HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.
Cat. No. Product name CAS No. Purity Chemical Structure
T67788 BAY-43-9695 233255-39-5 98%
BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.
T27586 IDX184 1036915-08-8 98%
IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 ...
T26815 BILB-1941 494856-61-0 98%
BILB-1941 is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.
T28830 Sovaprevir 1001667-23-7 98%
Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection.
T27696 JTK-109 480462-62-2 98%
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
T67787 Adafosbuvir PM 1613589-04-0 98%
Adafosbuvir PM is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.
T26863 BMS-929075 1217338-97-0 98%
BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic pa...
T68015 Ruzasvir 1613081-64-3 98%
Ruzasvir is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
T24480 MK-8325 1334314-19-0 98%
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability ...
T28762 Setrobuvir 1071517-39-9 98%
Setrobuvir is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s betw...
TN1033 Sennidin A 641-12-3 98%
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
TN1138 γ-Fagarine 524-15-2 98%
gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-i...
TN1034 Sennidin B 517-44-2 98%
Sennidin B stimulates glucose incorporation in rat adipocytes.
T5539 GS-443902 1355149-45-9 98%
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
TN3809 Dehydrojuncusol 117824-04-1 98%
Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
T12966 Sofosbuvir impurity K 1496552-51-2 98%
Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12969 Sofosbuvir impurity N 1394157-34-6 98%
Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12033 Micrococcin P1 67401-56-3 98%
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
T12965 Sofosbuvir impurity J 1334513-10-8 98%
Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12963 Sofosbuvir impurity H T12963 98%
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...
BAY-43-9695
T67788
BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.
IDX184
T27586
IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 ...
BILB-1941
T26815
BILB-1941 is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.
Sovaprevir
T28830
Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection.
JTK-109
T27696
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
Adafosbuvir PM
T67787
Adafosbuvir PM is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.
BMS-929075
T26863
BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic pa...
Ruzasvir
T68015
Ruzasvir is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
MK-8325
T24480
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability ...
Setrobuvir
T28762
Setrobuvir is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s betw...
Sennidin A
TN1033
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
γ-Fagarine
TN1138
gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-i...
Sennidin B
TN1034
Sennidin B stimulates glucose incorporation in rat adipocytes.
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
Dehydrojuncusol
TN3809
Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
Sofosbuvir impurity K
T12966
Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Sofosbuvir impurity N
T12969
Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Micrococcin P1
T12033
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
Sofosbuvir impurity J
T12965
Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Sofosbuvir impurity H
T12963
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...
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