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HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10493 Beclabuvir 958002-33-0 99.93%
Beclabuvir
Beclabuvir (BMS-791325) is a potent NS5A replication complex inhibitor that inhibits the activity of the NS5B protein expressed by HCV genotypes 1, 2, 4, and 5 a...
TN1033 Sennidin A 641-12-3 100%
Sennidin A
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
TN1138 γ-Fagarine 524-15-2
γ-Fagarine
gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-i...
TN1034 Sennidin B 517-44-2
Sennidin B
Sennidin B stimulates glucose incorporation in rat adipocytes.
T5539 GS-443902 1355149-45-9
GS-443902
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
TN3809 Dehydrojuncusol 117824-04-1 98%
Dehydrojuncusol
Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
T12966 Sofosbuvir impurity K 1496552-51-2 98%
Sofosbuvir impurity K
Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12969 Sofosbuvir impurity N 1394157-34-6 98%
Sofosbuvir impurity N
Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12033 Micrococcin P1 67401-56-3 98%
Micrococcin P1
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
T12965 Sofosbuvir impurity J 1334513-10-8 98%
Sofosbuvir impurity J
Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12963 Sofosbuvir impurity H 98%
Sofosbuvir impurity H
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...
T10067 2',5-Difluoro-2'-deoxycytidine 581772-30-7 98%
2',5-Difluoro-2'-deoxycytidine
2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.
T12967 Sofosbuvir impurity L 98%
Sofosbuvir impurity L
Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12968 Sofosbuvir impurity M 2095551-10-1 98%
Sofosbuvir impurity M
Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T73223 NS5A-IN-3 2764786-56-1 98%
NS5A-IN-3
NS5A-IN-3 (Compound 15) serves as a potent NS5A inhibitor, displaying exceptionally high efficacy against HCV genotype 1b, enhanced activity towards genotype 3a ...
T73834 NS5A-IN-2 2764786-74-3 98%
NS5A-IN-2
NS5A-IN-2 (Compound 33) serves as a potent NS5A inhibitor exhibiting exceptional efficacy against HCV genotype 1b, enhanced activity against genotype 3a (GT 3a),...
T16675 PSI-352938 1231747-17-3 98%
PSI-352938
PSI-352938 is an inhibitor of hepatitis C virus nucleotide.
TN3438 Arborinine 5489-57-6 98%
Arborinine
Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0....
TN5079 Sulochrin 519-57-3 98%
Sulochrin
Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotox...
T13281 Valopicitabine 640281-90-9 98%
Valopicitabine
Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic ...
Beclabuvir
T10493
Beclabuvir (BMS-791325) is a potent NS5A replication complex inhibitor that inhibits the activity of the NS5B protein expressed by HCV genotypes 1, 2, 4, and 5 a...
Sennidin A
TN1033
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
γ-Fagarine
TN1138
gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-i...
Sennidin B
TN1034
Sennidin B stimulates glucose incorporation in rat adipocytes.
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
Dehydrojuncusol
TN3809
Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
Sofosbuvir impurity K
T12966
Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Sofosbuvir impurity N
T12969
Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Micrococcin P1
T12033
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
Sofosbuvir impurity J
T12965
Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Sofosbuvir impurity H
T12963
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...
2',5-Difluoro-2'-deoxycytidine
T10067
2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.
Sofosbuvir impurity L
T12967
Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
Sofosbuvir impurity M
T12968
Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
NS5A-IN-3
T73223
NS5A-IN-3 (Compound 15) serves as a potent NS5A inhibitor, displaying exceptionally high efficacy against HCV genotype 1b, enhanced activity towards genotype 3a ...
NS5A-IN-2
T73834
NS5A-IN-2 (Compound 33) serves as a potent NS5A inhibitor exhibiting exceptional efficacy against HCV genotype 1b, enhanced activity against genotype 3a (GT 3a),...
PSI-352938
T16675
PSI-352938 is an inhibitor of hepatitis C virus nucleotide.
Arborinine
TN3438
Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0....
Sulochrin
TN5079
Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotox...
Valopicitabine
T13281
Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic ...
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TargetMol