td-1

Transdermal Peptide TD-1 HCl is a novel peptide for enhanced transdermal drug delivery that facilitates the penetration of the skin barrier by several drugs and large hydrophilic proteins, such as insulin and human growth hormoneb.

Transdermal Peptide (TD 1 peptide) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.Transdermal Pep

TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].

TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.

(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).

ITD-1 is a potent and highly selective TGFβ pathway inhibitor.

NMK-TD-100 is a microtubule modulating agent with anti-proliferative activity by disrupting microtubule functions through tubulin binding. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. Polymerization of tissue purifi

TD-198946, a potent chondrogenic agent, is a thienoindazole derivative.

TD139 is a small molecule inhibitor of inhaled galectin-3 (Gal-3) with potential anti-fibrotic activity, commonly used in the study of idiopathic pulmonary fibrosis.

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.

Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.

Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly reduces liver fat content. Berberine ursodeoxycholate has been used in studies of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes.

OR015002 shows toxicity to T. pyriformis with log(IGC50^-1) of 0.75.

4-Hydroxyindole is an aromatic heterocyclic compound that is widely studied in both scientific research and laboratory experiments. 4-Hydroxyindole is known for its antioxidant properties and has been used in a variety of applications, from cancer treatments to the prevention of neurodegenerative diseases.

1,3-Cyclohexadiene is used in the synthesis of many biologically active compounds and polymers.

MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

1-(3-METHYLBENZYL)PIPERAZINE, with CAS No. 5321-48-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(3-METHYLBENZYL)PIPERAZINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-(3-aminobenzyl)-N,N-diethylamine, with CAS No. 27958-97-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-(3-aminobenzyl)-N,N-diethylamine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7H-Pyrrolo[2,3-c]pyridin-7-one,1,6-dihydro-, with CAS No. 259684-36-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7H-Pyrrolo[2,3-c]pyridin-7-one,1,6-dihydro- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

EN300-1272604, with CAS No. 166904-37-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. EN300-1272604 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Pyrrolidin-2-yl-thiazole dihydrochloride, with CAS No. 1965309-49-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Pyrrolidin-2-yl-thiazole dihydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Benzenamine, 3-ethynyl-N-methyl- , with CAS No. 132056-23-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Benzenamine, 3-ethynyl-N-methyl- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

CYCLOHEPTENE compounds belong to the category of cycloolefin organic compounds. Its seven-membered ring that have moderate spatial tension, higher chemical stability, and is less likely to undergo side reactions such as spontaneous ring opening.

1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine, with CAS No. 20529-23-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.