neutrophil

AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH) inhibitor, exhibiting marked anti-inflammatory efficacy and high target selectivity.

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.

SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).

SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.

BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM for hFPR2 and 3.4 nM for mFPR2. BMS-986235 can be used in studies on the prevention of heart failure.

Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].

(25R)-Spirost-4-ene-3,12-dione, a natural product,

Neutrophilelastase inhibitor 5 (Compound 29) acts as a dual inhibitor of HNE (human neutrophil elastase) and protease 3 (PR3), with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophilelastase inhibitor 5 is applicable for research in neutrophil inflammatory diseases.

Neutrophilelastase inhibitor6 (compound 113) is an irreversible phosphonate-based inhibitor of human neutrophil elastase (neutrophilelastase).

Neutrophil elastase-IN-7 (Compound 12) is a potent inhibitor of human neutrophil elastase (HNE) with an IC50 of 0.54 μM. It also exhibits significant inhibitory activity against various coagulation proteins, with IC50 values of 8.2 μM for thrombin, 12.7 μM for FXa, 1.2 μM for FXIa, and 5.7 μM for FXIIIa. Neutrophil elastase-IN-7 is applicable in the study of inflammation, innate immune responses, and tissue remodeling.

Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with an IC50 of 42.30 nM and a Ki of 8.04 nM. It induces apoptosis in T47D cells and inhibits the proliferation of T47D, RPMI 8226, A549, and HSF cells with respective IC50 values of 21.25, 34.17, 29.93, and 99.11 nM [1].

Bovine neutrophil beta-defensin 12, an antimicrobial peptide originating from bovine neutrophils, exhibits antibacterial properties against Escherichia coli and Staphylococcus aureus [1].

Rabbit Neutrophil Peptide 3b is an antimicrobial peptide isolated from rabbit peritoneal neutrophils [1].

Neutrophil Gelatinase Associated Lipocalin (NGAL), Human (EC 6.1.1.3), is part of the lipid transport protein family and is primarily secreted by activated neutrophils. It binds to MMP-9, enhancing its activity and preventing its degradation. NGAL is mainly recognized as a biomarker for acute kidney injury and is released following renal tubular damage and during kidney regeneration.

Myeloperoxidase, Human Neutrophil, is a peroxidase enzyme that acts as a potent antimicrobial agent by catalyzing the oxidation of chloride ions dependent on H2O2, producing hypochlorous acid. It also facilitates the degradation of N-retinylidene-N-retinyl-ethanolamine [a toxic form of retinal lipofuscin], and induces lysosomal stress and cell death. This enzyme is useful for research in inflammation and infection.

Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammation. Elubrixin is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist.

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.

2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one targets the Neutrophil elastase (human).

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef