Search Result

Search Results for " neutrophil "

140

Compounds

Natural Products

119

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T81316	Rabbit neutrophil peptide 3b
	Rabbit Neutrophil Peptide 3b is an antimicrobial peptide isolated from rabbit peritoneal neutrophils [1].
T79397	Neutrophil elastase inhibitor 4
	Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM. It prompts apoptosis in T47D cells and inhibits the proliferation of T4...
T80323	Bovine neutrophil beta-defensin 12	BNBD-12
	Bovine neutrophil beta-defensin 12, an antimicrobial peptide originating from bovine neutrophils, exhibits antibacterial properties against Escherichia coli and Staphylococcus aureus [1].
T9964	BOS-318		Others
	BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.		Others
T8844	Diflapolin		Others , FLAP , Epoxide Hydrolase
	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.		Others , FLAP , Epoxide Hydrolase
T21938	AS-041164		PI3K
	AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory e...		PI3K
T2121	SW033291		Dehydrogenase
	SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.		Dehydrogenase
T13951	UCB-9260		TNF
	UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.		TNF
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T16850	SB-265610	GSK-CXCR2	CXCR
	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...		CXCR
T39789	BMS-986235	BMS-986235,LAR-1219	Others
	BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the preventio...		Others
T14667	BLT-1		Others , HCV Protease
	BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.		Others , HCV Protease
T9516	Binodenoson	WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos	Adenosine Receptor
	Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres...		Adenosine Receptor
T3107	Alvelestat	AZD9668,Avelestat	Others , Serine Protease
	Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.		Others , Serine Protease
T6986	Sivelestat	ONO5046,EI546,LY544349	Others , SARS-CoV , Serine Protease
	Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.		Others , SARS-CoV , Serine Protease
T7130	Navarixin	MK-7123,SCH 527123	CXCR
	Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef...		CXCR
T11828	LDC7559		Pyroptosis
	LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.		Pyroptosis
T12613L	BAY-85-8501		Serine Protease
	BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE; IC50 of 65 pM)		Serine Protease
T8563	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one		Serine Protease
	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.		Serine Protease
T35367	Thioacetamide	TAA	Others
	Thioacetamide is a hepatotoxicant used widely to induce experimental liver lesions, develops hepatocellular necrosis and subsequent inflammation (mainly M1-/M2-macrophages without neutrophil infiltration) in rats.		Others
T68099	Midesteine	MR-889	Others
	Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.		Others
T8602	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE		Serine Protease
	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).		Serine Protease
TP2083L	Ac9-25 acetate	Ac9-25 acetate(284040-76-2 free base)	Others
	Ac9-25 acetate is an annexin AI peptide and activates the neutrophil reduced nicotinamide adenine dinucleotide phosphate oxidase through FPR but not through FPRL1.		Others
T28974	Ticolubant		Calcium Channel , LTR
	Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inf...		Calcium Channel , LTR
T37379	Protectin D1
	Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phag...
T10473	BAY-678		Others
	BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).		Others
T22277L	BMS-P5 free base		PAD
	BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-...		PAD
TP2334	PMX 53 acetate(219639-75-5 free base)		Complement System
	PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an ag...		Complement System
T25131	AZD8309	AZD 8309,AZD-8309	Glutathione Peroxidase , CXCR
	AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the...		Glutathione Peroxidase , CXCR
T20762	Sivelestat sodium tetrahydrate	ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046	Serine Protease
	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for...		Serine Protease
T76884	Spesolimab	BI 655130	IL Receptor
	Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biomarkers associated with congenital Th1/Th17 and neutrophil p...		IL Receptor
T10831L	Cl-amidine hydrochloride		Apoptosis , PAD
	Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro ca...		Apoptosis , PAD
T74485	STC314		Others
	STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute r...		Others
T36503	Sodium Hydrogen Sulfide (hydrate)		Others
	Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sul...		Others
T13389	ZD-0892		PI3K
	ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectively).		PI3K
T3107L	Alvelestat tosylate
	Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation.
T10254	AE-3763		Serine Protease
	AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).		Serine Protease
T17288	ZD8321		Serine Protease
	ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).		Serine Protease
T15285	FK706		Serine Protease
	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively)...		Serine Protease
T31877	Freselestat	ONO-PO 736,ONO-6818,ONO 6818,ONO6818
	Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
T25783	MDL 27399	MDL-27,399,MDL 27,399,MDL27399,MDL27,399
	MDL 27399 suppresses human neutrophil cathepsin G.
T25520	ICI 200355	ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355
	ICI 200355 is an inhibitor of human neutrophil elastase.
T25781	MDL 101146	MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146
	MDL 101146 is an orally active neutrophil elastase inhibitor.
T26929	BVT173187	BVT 173187,BVT-173187
	BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.
T25521	Ici 200880	Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880
	Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.
T70219	ISP-VT
	ISP-VT is a Novel inhibitor of COX and neutrophil migration.
T25782	MDL 27324	MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324
	MDL 27324 is an inhibitor of human neutrophil elastase.
T25518	Ici 186756	Ici186756,Ici--186756
	Ici 186756 is a novel, effective, and selective inhibitor of human neutrophil elastase.
T25784L	MDL-101146, (S)-	MDL101146, (S)-
	MDL-101146, (S)- is an effective orally active inhibitor of human neutrophil elastase.
T69790	GW-475151
	GW-475151 inhibits human neutrophil elastase (HNE).

Compounds

Rabbit neutrophil peptide 3b

T81316

Synonym:

Target:

Neutrophil elastase inhibitor 4

T79397

Synonym:

Target:

Bovine neutrophil beta-defensin 12

Target: Others, FLAP, Epoxide Hydrolase

Target: Dehydrogenase

Target: IL Receptor, CXCR

Synonym: BMS-986235,LAR-1219

Target: Others, HCV Protease

Binodenoson

T9516

Synonym: WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos

Target: Adenosine Receptor

Alvelestat

T3107

Synonym: AZD9668,Avelestat

Target: Others, Serine Protease

Sivelestat

T6986

Synonym: ONO5046,EI546,LY544349

Target: Others, SARS-CoV, Serine Protease

Navarixin

T7130

Synonym: MK-7123,SCH 527123

Target: Serine Protease

2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one

T8563

Synonym:

Target: Serine Protease

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE

T8602

Synonym:

Target: Serine Protease

Ac9-25 acetate

TP2083L

Synonym: Ac9-25 acetate(284040-76-2 free base)

Target: Calcium Channel, LTR

PMX 53 acetate(219639-75-5 free base)

TP2334

Synonym:

Target: Complement System

AZD8309

T25131

Synonym: AZD 8309,AZD-8309

Target: Glutathione Peroxidase, CXCR

Sivelestat sodium tetrahydrate

T20762

Synonym: ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046

Target: Serine Protease

Cl-amidine hydrochloride

T10831L

Synonym:

Target: Apoptosis, PAD

Sodium Hydrogen Sulfide (hydrate)

Target: Serine Protease

ZD8321

T17288

Synonym:

Target: Serine Protease

FK706

T15285

Synonym:

Target: Serine Protease

Freselestat

T31877

Synonym: ONO-PO 736,ONO-6818,ONO 6818,ONO6818

Target:

MDL 27399

T25783

Synonym: MDL-27,399,MDL 27,399,MDL27399,MDL27,399

Target:

ICI 200355

T25520

Synonym: ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355

Target:

MDL 101146

T25781

Synonym: MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146

Target:

BVT173187

T26929

Synonym: BVT 173187,BVT-173187

Target:

Ici 200880

T25521

Synonym: Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880

Synonym: MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324

Target:

Ici 186756

T25518

Synonym: Ici186756,Ici--186756

Target:

MDL-101146, (S)-

T25784L

Synonym: MDL101146, (S)-

Cat No.	Product Name	Synonyms	Targets
TN6737	(25R)-Spirost-4-ene-3,12-dione		Others
	(25R)-Spirost-4-ene-3,12-dione is a natural product.		Others
T13864	Resolvin D1	RvD1	Others
	Resolvin D1 is an endogenous pro-resolving mediator of inflammation, blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagoc...		Others
TN1006	Tirucallol		NOS , NO Synthase , Prostaglandin Receptor
	Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.		NOS , NO Synthase , Prostaglandin Receptor
TJS0314	5,7-Dihydroxy-4-methylcoumarin	Methyl-2H-Chromen-2-One,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin	Others , Antibacterial , Antifungal
	5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) inhibits human neutrophil oxidative metabolism and elastase activity. 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property. 5,7-Dihydroxy-...		Others , Antibacterial , Antifungal
T4S2063	Tetrahydrocoptisine	STYLOPINE	ERK , p38 MAPK , NF-κB
	1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo...		ERK , p38 MAPK , NF-κB
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T13661	Docosatrienoic Acid	cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Others
	Docosatrienoic acid is a rare omega-3 fatty acid; Ki value is 5×M, which inhibits the binding of LTB4 to porcine neutrophil membrane.		Others
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and p...
T5768	Bruceine B		TNF , Parasite
	Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated ...		TNF , Parasite
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits n...
TN4303	Isokaempferide		ATPase , Potassium Channel , Calcium Channel , TNF , Prostaglandin Receptor
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, m...
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3....
TN5228	Vestitol		Antifection
	Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from...		Antifection
TN4584	Morolic acid		IL Receptor , COX , HIV Protease
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediat...		IL Receptor , COX , HIV Protease

Natural Products

(25R)-Spirost-4-ene-3,12-dione

Target: NOS, NO Synthase, Prostaglandin Receptor

5,7-Dihydroxy-4-methylcoumarin

TJS0314

Synonym: Methyl-2H-Chromen-2-One,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin

Target: Others, Antibacterial, Antifungal

Tetrahydrocoptisine

T4S2063

Synonym: STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Sauchinone

T6S1572

Synonym:

Target: ERK, p38 MAPK, NF-κB

Docosatrienoic Acid

T13661

Synonym: cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid

Target: TNF, Parasite

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

Target: IL Receptor, COX, HIV Protease

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03660	P67phox Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPY-03619	P67phox Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPH-01163	CXCL5 Protein, Human, Recombinant (His)	Human	E. coli
	CXCL5 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02997	Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO)	Mycobacterium smegmatis	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPJ-00082	NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes w...
TMPJ-00848	NCF1 Protein, Human, Recombinant (His)	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a mem...
TMPH-01772	DEFA1 Protein, Human, Recombinant (GST)	Human	E. coli
	Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing thei...
TMPH-02503	DEFA1 Protein, Mouse, Recombinant (GST & His)	Mouse	E. coli
	Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium.
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPH-01773	ELANE Protein, Human, Recombinant (GST)	Human	E. coli
	Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane pro...
TMPJ-00541	CD177 Protein, Human, Recombinant (His)	Human	Human Cells
	CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is express...
TMPH-01070	CD177 Protein, Human, Recombinant (GST & His)	Human	E. coli
	In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integri...
TMPH-03751	CYBB Protein, Human, Recombinant (His)	Human	E. coli
	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membr...
TMPY-00672	Azurocidin/CAP37 Protein, Human, Recombinant (His)	Human	HEK293
	Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil...
TMPY-00915	Serpin A1 Protein, Human, Recombinant (His)	Human	HEK293
	SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
TMPY-00970	CD31/PECAM-1 Protein, Human, Recombinant (His)	Human	HEK293
	The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transm...
TMPY-01834	CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)	Mouse	HEK293
	Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional...
TMPY-01850	CEACAM3 Protein, Human, Recombinant (His)	Human	HEK293
	CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66...
TMPY-00472	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99)	Human	E. coli
	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-04726	IL-8/CXCL8 Protein, Human, Recombinant (His)	Human	Yeast
	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-00754	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)	Human	HEK293
	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-01884	MMP-8 Protein, Human, Recombinant	Human	HEK293
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPY-02698	CD14 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00873	Lipocalin-2/LCN2 Protein, Human, Recombinant (His)	Human	HEK293
	Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells,...
TMPY-00988	Lipocalin-2/LCN2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells,...
TMPY-05057	Complement C5 Protein, Human, Recombinant (His & FLAG)	Human	HEK293
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-00653	Complement C5 Protein, Human, Recombinant (Complement C5a)	Human	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-04902	Complement C5a Protein, Mouse, Recombinant	Mouse	E. coli
	C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPK-01189	PS20 Protein, Human, Recombinant (His)	Human	E. coli
	The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory i...
TMPK-01173	PS20 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory i...
TMPK-01315	PS20 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory i...
TMPH-03522	Alpha-hemolysin Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	Yeast
	Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probabl...
TMPH-03523	Alpha-hemolysin Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probabl...
TMPK-00675	CD24 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated	Cynomolgus	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-01318	CD24 Protein-VLP, Cynomolgus, Recombinant	Cynomolgus	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPY-01909	Elafin Protein, Human, Recombinant (His)	Human	HEK293
	Elafin, also known as Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, PI3, WAP3 and WFDC14, is a secreted protein ...
TMPK-00004	CD24 Protein, Human, Recombinant (GST)	Human	E. coli
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00674	CD24 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00006	CD24 Protein (Primary Amine Labeling), Human, Recombinant (mFc), Biotinylated	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPY-02847	Moesin Protein, Human, Recombinant (aa 1-346, His)	Human	E. coli
	Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. It seems that ERM protei...
TMPK-00005	CD24 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00003	CD24 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00002	CD24 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPK-00001	CD24 Protein-VLP, Human, Recombinant	Human	HEK293
	CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo...
TMPH-02658	FPR1 Protein, Mouse, Recombinant (GST & His & Myc)	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release...
TMPJ-01060	CXCL6 Protein, Human, Recombinant (His)	Human	Human Cells
	Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. It is a potent neutrophil chemotactic and activating factor and it exhibits extensive similarity to other CXC chemokines...
TMPH-02659	FPR2 Protein, Mouse, Recombinant (GST & His & Myc)	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors. Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several li...
TMPH-01346	FPR1 Protein, Human, Recombinant (GST & His & Myc)	Human	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release...
TMPJ-00833	MPO Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride,...
TMPH-03119	SERPINB1 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	E. coli
	Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the ...
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