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Results for "

neutrophil

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    181
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
AS-041164
T219386318-41-8
AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.
  • $52
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UCB-9260
T139511515888-53-5
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
  • $98
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BLT-1
T14667321673-30-7
BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.
  • $38
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SB-265610
GSK-CXCR2
T16850211096-49-0
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).
  • $51
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BMS-986235
LAR-1219, BMS-986235
T397892253947-47-4
BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM for hFPR2 and 3.4 nM for mFPR2. BMS-986235 can be used in studies on the prevention of heart failure.
  • $64
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Neutrophil elastase inhibitor 4
T79397
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with an IC50 of 42.30 nM and a Ki of 8.04 nM. It induces apoptosis in T47D cells and inhibits the proliferation of T47D, RPMI 8226, A549, and HSF cells with respective IC50 values of 21.25, 34.17, 29.93, and 99.11 nM [1].
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Bovine neutrophil beta-defensin 12
BNBD-12
T80323455257-02-0
Bovine neutrophil beta-defensin 12, an antimicrobial peptide originating from bovine neutrophils, exhibits antibacterial properties against Escherichia coli and Staphylococcus aureus [1].
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Rabbit neutrophil peptide 3b
T81316
Rabbit Neutrophil Peptide 3b is an antimicrobial peptide isolated from rabbit peritoneal neutrophils [1].
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Neutrophil Elastase,Human
Leukocyte elastase,Serine elastase,Neutrophil Elastase (NEG),Human,ELA-2
T89176
NeutrophilElastase(NEG) serves as a biomaterial or organic compound applicable in life sciences research.
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BAY-678
T10473675103-36-3In house
BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).
  • $33
In Stock
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Elubrixin
SB-656933
T11179688763-64-6In house
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammation. Elubrixin is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist.
  • $117
In Stock
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ZD-0892
T13389171964-73-1In house
ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.
  • $119
In Stock
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azd8309
AZD-8309, AZD 8309
T25131333742-48-6In house
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.
  • $129
In Stock
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JNJ-10311795
RWJ-355871, RWJ355871, JNJ10311795
T27660518062-14-1In house
JNJ-10311795 (RWJ-355871) is a potent dual inhibitor of neutrophil elastase (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM) with significant anti-inflammatory activity, useful for studying pneumonia.
  • $293
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ticolubant
T28974154413-61-3In house
Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
  • $126
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midesteine
MR-889
T6809994149-41-4In house
Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.
  • $46
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PMSF
Phenylmethylsulfonyl fluoride, Benzylsulfonyl fluoride
T0789329-98-6
PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine cysteine protease and is often used in the preparation of cell lysates.
  • $33
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Thioacetamide
TAA
T3536762-55-5
Thioacetamide (TAA) is an indirect hepatotoxin commonly used to induce experimental liver injury. It is metabolized by CYP2E1 into reactive metabolites that covalently bind to proteins and lipids, leading to oxidative stress and centrilobular necrosis, hepatocyte death, and M1 M2 macrophage-dominated inflammation. TAA is widely used to establish models of chronic liver fibrosis, hepatic encephalopathy, and liver cancer.
  • $33
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Sodium Hydrogen Sulfide (hydrate)
T36503207683-19-0
Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sulfide (hydrate) is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration, reduces airway inflammation, and protects neurites, heart, and intestine from chemical or ischemic-reperfusion damage.
  • $50
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Sivelestat
ONO5046, EI546, LY544349
T6986127373-66-4
Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
  • $42
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Lodelaben
SC-39026, SC39026, Declaben
T11865111149-90-7
Lodelaben (Declaben, SC-39026) is a reversible, non-competitive inhibitor of human neutrophil elastase (HNE), characterized by specificity and potency (IC50=0.5 μM, Ki=1.5 μM).
  • $293
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GW311616 hydrochloride
GW311616A
T11525L197890-44-1In house
GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
  • $287
35 days
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SSR 69071
T21989344930-95-6In house
SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase, displaying higher affinity for human elastase (Ki = 0.0168 nM) compared to rat (Ki = 3 nM), mouse (Ki = 1.8 nM), and rabbit (Ki = 58 nM) elastases [2]. It reduces myocardial infarct size following ischemia-reperfusion injury [1] and has potential for treating chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis, and various inflammatory diseases.
  • $113
35 days
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Navarixin
MK-7123, SCH 527123
T7130473727-83-2
Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.
  • $34
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